Laboratory of Intracellular signaling

Monitoring of intracellular redox characteristics and studying the role of redox active compounds in regulating the processes of self-renewal, differentiation and reprogramming of multipotent and pluripotent stem cells. Development of protocols for quantitative characterization of redox parameters of cells (intracellular concentration of hydrogen peroxide, rate constants of redox reactions) using genetically encoded sensors of redox-active compounds.

Analysis of the therapeutic potential of human mesenchymal stromal/stem cells (MSCs), as well as 3D cellular systems based on them; development of approaches for the correction of various human pathologies (Ascherman syndrome, skin wounds, Duchenne myodystrophy) using stem cells.