Laboratory of chemical regulation of biocatalysis
Head of Laboratory
Solyev, Pavel N
PhD in Chemistry
Publications
67
Citations
458
h-index
12
Authorization required.
Research in the laboratory is focused on studying the mechanisms of action of pyridoxal-5’-phosphate-dependent enzymes, as well as their use in enzyme therapy for the treatment of socially significant diseases.
- Synthesis of biologically active compounds
- Creation of genetically engineered structures for the expression of target proteins
- Protein crystallization
Research directions
Study of the mechanisms of action of pyridoxal-5’-phosphate-dependent enzymes
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Over the past two decades, the main objects of research were: beta-eliminating lyases, tyrosine phenol lyase (CF 4.1.99.2) and tryptophan–indole lyase (CF 4.1.99.2), and gamma-eliminating methionine-gamma lyase (CF 4.4.1.11). In addition to studying enzymatic reactions, we broaden the pathways of biosynthesis of biologically active compounds, develop methods for the organic synthesis of isosteric substrates and improve methods for targeted enzyme delivery.
Publications and patents
Виталия Викторовна Куликова, Елена Андреевна Морозова, Наталья Валерьевна Ануфриева, Светлана Владимировна Ревтович, Василий Сергеевич Коваль, Анна Дмитриевна Лыфенко, Юрий Федорович Белый, Татьяна Викторовна Демидкина
RU2814985,
2023
Павел Николаевич Сольев, Дарья Константиновна Шерман, Наталья Фанисовна Закирова, Сергей Николаевич Кочетков
RU2759291,
2021
Partners
Lab address
ул. Вавилова, 32, стр. 1, Москва
Authorization required.