Tianshui Normal University
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Publications
1 002
Citations
10 527
h-index
47
Top-3 journals
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Advanced Materials Research
(46 publications)
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Applied Mechanics and Materials
(23 publications)
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Chinese Chemical Letters
(18 publications)
Top-3 organizations
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Lanzhou University
(112 publications)
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Northwest Normal University
(84 publications)
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Xi'an Technological University
(46 publications)
Top-3 foreign organizations
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Naresuan University
(8 publications)
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Qassim University
(8 publications)
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Suranaree University of Technology
(8 publications)
Most cited in 5 years
Found
Publications found: 1300
Retroplacental blood – a new substrate for clinical trials
Samusevich A., Proskurnina E., Ignatko I., Panina O.
In review we focus on the features of maternal arterial blood entering the intervillous space from the spiral arteries. Besides the definition of the term "retroplacental blood," in our article we provide a method of this blood sampling. In addition, presents the results of all retroplacental blood researches by now, which were related to the study of immunological indicators, hormones and hormone-like substances, as well as enzymes. Thus, retroplacental blood is a unique and almost unexplored biological substrate that may be useful for clinical medicine.
Secondary osteoporosis: a disease with serious consequences
Sergeeva-Kondrachenko M., Terina N.
Secondary osteoporosis (OP) develops as a result of somatic pathologies (endocrine, genetic diseases, kidney damage, gastrointestinal tract, etc.), lifestyle habits or medications. Any patient with suspected secondary OP must undergo a series of laboratory tests (full clinical blood test, biochemical blood test, blood test for 25-hydroxyvitamin D, parathyroid hormone, etc.). The “gold standard” for instrumental diagnosis of OP is dual-energy X-ray densitometry of the lumbar spine and proximal femur to assess bone mineral density. Treatment of secondary OP is etiological, aimed at identifying and eliminating the underlying cause of the disease, which usually involves discontinuation of medications (if possible) and correction of modifiable risk factors. If it is impossible to influence the cause of secondary OP, pathogenetic therapy is used, including antiresorptive drugs, agents that enhance bone formation, and monoclonal antibodies. It is important to remember that the effectiveness of treatment of OP is influenced by indicators of phosphorus-calcium metabolism, therefore, before starting pathogenetic therapy, it is necessary to determine the levels of calcium, phosphorus and 25-hydroxyvitamin D in the blood, bring these indicators to normal values, and then continue taking these drugs along with pathogenetic therapy. To do this, they recommend a diet balanced in calcium, phosphorus and proteins, and the prescription of vitamin D supplements and calcium salts. One of the effective means for normalizing phosphorus-calcium metabolism is the drug Osteomed Forte.
Factors of early neonatal maladaptation of late preterm infants
Panina N., Ippolitova L., Kaledina E., Kogutnitskaya M., Korotaeva N.
Late preterm infants are more susceptible to various unfavorable factors than preterm infants. The leading place in the structure of morbidity, as well as the formation of long-term unfavorable outcomes in this group of children is occupied by respiratory disorders, impaired or delayed neurodevelopment. In order to study in detail the pathological conditions leading to adaptation disorders, we retrospectively analyzed the data of developmental histories of late premature infants and delivery histories. The relationship between placental abnormalities, including fetal growth and developmental delays, fetal conception, history of pregnancy termination, low birth weight, age of the woman in labor and increased need for respiratory support, as well as clinical manifestations of cerebral ischemia in newborns at 34 0/7–36 6/7 weeks gestation was revealed
Electronic medical record in neonatology. Development and implementation experience
Svetlakova D., Starkov V., Ankudinov N., Shestak E., Dodrov D.
Electronic medical record (EMR) improves the quality of medical services and the speed of transfer of medical information between organizations and the patient. Purpose. To share the experience of developing a neonatal module and its implementation in a medical organization, and also, to show the advantages and disadvantages of EMR, the problems faced by the authors of the article during the development and implementation of EMR and their solutions. Methods. The experience of developing and implementing the neonatal module of the automated information system Regional Obstetric Monitoring (AIST ROM) on the basis of the Yekaterinburg Clinical Perinatal Center is presented. Results. After studying the regulatory framework, an EMR of the patient was developed and implemented. The neonatal module of AIST ROM includes all the necessary documents. The problems we have encountered in the development and implementation process are common. After studying the literature and taking into account the peculiarities of our medical organization, certain ways of solving them are proposed. Conclusion. EMR in neonatology will improve the quality of care, reduce the number of errors, ensure the availability of information, and reduce the burden on medical personnel.
Assessment of neutrophil functions in children with latent tuberculosis infection with different sensitivity to recombinant tuberculosis allergen
Mordyk A., Romanova M., Zolotov A., Novikov D., Kirichenko N., Ptukhin A.
Purpose. To evaluate the ability of neutrophils to form extracellular traps in children with latent TB infection with different sensitivity to recombinant tuberculosis allergen (ATR) to form an individual approach to therapeutic and preventive measures. Material and methods. The study involved 22 children with a moderate and mild reaction to ATP (group 1) and 31 children with a pronounced reaction (group 2). Results. According to the general clinical blood test, there were no differences between the groups. The median of intact neutrophils in group 1 was 52.0, in group 2 – 35.6 (p=0.251). The median of hyperactivated neutrophils in group 1 was 10.7, in group 2 – 2.9 (p=0.0295). Conclusion. In the group with a pronounced reaction to ATR (group 2), there was an increased readiness of neutrophils to form extracellular traps (the number of early NETosis cells exceeds that in the comparison group) and a greater number of formed cloud-like neutrophil extracellular traps (incomplete NETosis). At the same time, in children with a calmer reaction to the test with ATR (weak and moderately expressed), the readiness of neutrophils to form extracellular traps is observed, but at the same time hyperactivation of the neutrophil and the formation of full-fledged thread-like neutrophil traps are achieved.
The role of nutrients in the prevention of noncommunicable diseases
Amlaev K., Atoeva M., Baratova M., Vohidov U.
The role of nutrients in the prevention of non-communicable diseases (NCDs) is reviewed. Diseases such as osteoporosis, arterial hypertension, dementia, visual impairment and others are sensitive to a deficiency of certain macro and micronutrients, while their progression is accelerated. The role of micronutrients such as vitamin D, B vitamins, carotenoids, as well as lutein, omega-3 fatty acids in slowing the development of NCDs with age has been noted. The data on the effect of the Mediterranean diet and the DASH diet on blood pressure levels are presented. It is indicated that the greatest effect of nutritional interventions is more pronounced in populations with low baseline intake of these nutrients.
The evolution of surgical treatment of hemorrhoidal disease: historical review
Pletner P., Azimov R., Shemyatovsky K., Gorsky V., Glushkov P., Cherepenin M., Levikin K.
Hemorrhoidal disease is the most common of all diseases of the rectum, the first mention of which dates back to the XVIII century BC. Methods of surgical treatment of hemorrhoidal disease are aimed at both minimizing the pain syndrome and early postoperative rehabilitation. They have evolved over many centuries and currently continue to improve. This historical review presents the changes in trends in the surgical treatment of hemorrhoidal disease.
Support for young scientists in Kazakhstan: current status, problems and solutions
Rakhmanberdi N., Zhussupova G., Skvirskaya G., Volnuhin A.
This article examines the current state of support for young scientists in Kazakhstan, identifies the key problems they face, and suggests solutions to improve the effectiveness of existing measures. The normative acts and programs aimed at supporting young people in the scientific field are analyzed. Specific consideration is given to the present difficulties and potential solutions to enhance the appeal of scientific research careers for young scientists in Kazakhstan. As a result of the research, recommendations are proposed to improve the material and technical base, stimulate scientific activity and create conditions for the full participation of young scientists in scientific processes
Technology of surgical guide development: practical application in implantology
Osmanova N.
Purpose. To examine and describe the steps involved in creating a surgical guide for dental implant installation, and to assess the advantages of using surgical guides compared to traditional implant placement methods. Materials and methods. The study utilized data from cone-beam computed tomography, intraoral scanning, and specialized software for data merging and surgical guide modeling. A clinical case with the installation of three implants was analyzed to evaluate the effectiveness of the method. Additionally, 15 similar cases were reviewed where implant placement was performed without using a surgical guide to compare operation times. Results. The results showed that using a surgical guide reduced the operation time to 23 minutes compared to the average duration of 58 minutes with the traditional method. Conclusions. The use of guides minimizes the need for constant checks and adjustments, reduces the risk of complications, and improves patient comfort by shortening the time spent on the operating table. Patients feel more confident in the outcome since the template minimizes the likelihood of medical errors
Changes in cortisol, prolactin and oxytocin levels in pregnant women after perinatal training programs
Keshchyan L., Grishkova N.
Purpose. To study changes in the levels of cortisol, prolactin and oxytocin in the blood serum of pregnant women depending on the perinatal preparation program used. Material and methods. The study involved 537 women at 34 weeks of pregnancy, who were divided into 2 groups: main (n=273) – pregnant women who underwent perinatal training under the “Conscious Motherhood” program; comparison group (n=264) – pregnant women who were trained under the program of a traditional maternity school. The levels of the studied hormones were determined by enzyme immunoassay. Results. The initial levels of cortisol, prolactin and oxytocin in the groups did not differ significantly and corresponded to the reference values for pregnant women. After classes in perinatal training programs, the levels of cortisol and prolactin did not change significantly and did not differ between groups. Classes in the “Conscious Motherhood” program increased the content of oxytocin by 2.2 times, while in the comparison group (traditional motherhood school) no significant changes were detected. Conclusion. Thus, perinatal preparation does not affect the levels of cortisol and prolactin. At the same time, classes in the “Conscious Motherhood” program, conducted together with husbands, cause an increase in oxytocin levels, which may have a beneficial effect on the course of childbirth.
PRINCIPLES OF PRESCRIBING CALCIUM SUPPLEMENTS AND VITAMIN D: THE VIEW OF A CLINICAL PHARMACOLOGIST AND RHEUMATOLOGIST
Potupchik T., Kapustina E., Kucherenko A., Klyuchnikova E.
The article analyzes scientific research on the use of calcium and vitamin D preparations. The role of calcium and vitamin D in bone tissue homeostasis is shown. A review of calcium and vitamin D medicines registered in the Russian Federation has been conducted. Special attention is paid to one of the urgent pharmacological and therapeutic problems – safety. Research data demonstrate that calcium and vitamin D supplements have a positive effect on bone metabolism and bone strength. It has been revealed that an overdose of calcium and vitamin D may have undesirable consequences for human health, in particular, increased stone formation and the development of urolithiasis. One of the solutions to the problems associated with the risk of overdose may be the use of biologically active additives Osteomed, Osteo-Vit D3, Osteomed Forte.
Features of subgingival biofilm microbiota in adolescents with type 1 diabetes mellitus
Shcherbakova M., Bochkalova T., Allahverdiev А., Levina I., Morozova N.
Purpose. To study the composition of microbiota of subgingival biofilm using the GCMS method (according to Osipov). Materials and methods. The study involved 30 patients with ICD-10 diagnosis E10 “Insulin-dependent diabetes mellitus” and 30 adolescents without general medical pathology (conditionally healthy children) aged 13 to 17. The condition of periodontal tissues was evaluated by periodontal indices: GI, PMA, SBI. Microbiota was evaluated by gas chromatography-mass spectrometry (CGMS) (according to Osipov). Results. The SBI index in adolescents with type 1 diabetes mellitus (DM) was 2.15±0.09 scores, the index of the control group – 1.67±0.02 scores, GI index – 2.34±0.08 and 1.33±0.08 scores respectively, PMA index – 67.80±1.09 and 33.70±2.86% respectively. According to the results of CGMS analysis (according to Osipov), a statistically significant increase in the indices in patients with type 1 DM was observed in microorganisms: Actinomyces spp., Eubacterium spp., Moraxella spp., Prevotella spp., Staphilococcus aureus, Bacteroides spp. and yeast-like fungi (Candida albicans). Conclusion. The results obtained indicate an increase in periodontopathogenic microbiota in the subgingival biofilm in adolescent patients with type 1 DM
Analysis of methods of adhesion prevention in patients after abdominal and pelvic surgery
Onosovskaya A., Kiyry A., Kutsenko V., Seliverstov P.
The article examines options for preventing adhesive disease based on a comparative analysis of methods of barrier prevention of adhesion formation and the use of immunomodulatory drugs.
Optimization of diagnostics of urogenital tract infections caused by obligate pathogens in women
Lipova E., Vitvitskaya Y., Glazko I., Karasev E., Volgin V.
Sexually transmitted infections remain an important medical and social problem. Untimely detection and, accordingly, late initiation of treatment lead to chronicity of the infectious-inflammatory process and the development of complications such as infertility. Purpose. Assess the validity of diagnosing an infectious-inflammatory process based on the results of a microscopic examination - leukocyte reaction. Material and methods. A retrospective analysis of medical records of 102 women was carried out, the results of microscopic examination, polymerase chain reaction (PCR), and real-time PCR were analyzed. Results. The clinical picture in patients with obligate pathogens and patients with an inflammatory process caused by opportunistic microorganisms did not differ significantly: slightly and moderately severe clinical symptoms predominated. The infectious-inflammatory process caused by obligate pathogens was accompanied by an increase in the number of polymorphonuclear leukocytes only in 22.73% of cases; in other cases, the pathological process proceeded without a leukocyte reaction. Conclusion. When diagnosing an infectious-inflammatory process, it is necessary to use not only routine methods, but also screening studies aimed at excluding obligate pathogens.
Disturbance of vaginal microbiocenosis as a cofactor in the development of HPV-associated cervical pathology
Shtakh A., Sokolova V., Troshin D., Kandrashkina Y., Yuskaeva G.
The development of cervical intraepithelial neoplasia (CIN) and cervical cancer is significantly associated with long-term persistence of oncogenic strains of human papillomavirus (HPV). Only 10% of cases of HPV infection are characterized by long-term persistence of the virus with the development of CIN, which indicates the presence of cofactors. One of the cofactors in the development of CIN may be vaginal dysbiosis. Purpose. To study the relationship between disturbances in vaginal microbiocenosis and the presence of HPV-associated cervical lesions. Material and methods. The study involved 58 women, of whom 3 groups were formed: 1st (n=18) – patients with CIN I; 2nd (n=21) – patients with CIN II–III; 3rd (n=19; control) – patients without neoplastic changes. 4 types of microbiocenosis have been formed: absolute normocenosis; conditional normocenosis; moderate dysbiosis; pronounced dysbiosis. Results. Vaginal dysbiosis in patients with HPV infection can be considered as a marker, as well as a possible predictor of the development of dysplastic processes in the epithelium of the cervix. A relationship has been identified between disturbances in vaginal microbiocenosis and the presence of HPV-associated cervical lesions, but true cause-and-effect relationships have not been established. Conclusion. Correction of vaginal microflora can be a decisive event in the elimination of HPV. Future studies should also consider the role of the immune system in the development of CIN.
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