Changchun Normal University
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Publications
1 429
Citations
18 246
h-index
60
Top-3 journals
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Journal of Separation Science
(30 publications)
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Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
(26 publications)
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Advanced Materials Research
(23 publications)
Top-3 organizations
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Jilin University
(253 publications)
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Northeast Normal University
(177 publications)
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Wenzhou University
(36 publications)
Top-3 foreign organizations
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University of Tehran
(21 publications)
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King Abdulaziz University
(8 publications)
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Samara National Research University
(8 publications)
Most cited in 5 years
Found
Publications found: 1091
Negative emotional states and metabolic disorders in arterial hypertension in coal industry workers
Danilov I.P., Vlakh N.I., Paneva N.Y., Logunova T.D.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2025
,
citations by CoLab: 0
|
Abstract
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Introduction. Arterial hypertension, due to its prevalence and severity of complications, is one of the leading causes of disability of the working population. Psychosocial factors, including negative emotional states, are recognized as independent risk factors for the development of cardiovascular diseases. The relationship between negative emotional states and arterial hypertension in miners of coal enterprises remains poorly understood.
The study aims to consider the relationship of negative emotional states and metabolic disorders with arterial hypertension in coal mining workers.
Materials and methods. The scientists examined 313 employees of coal enterprises with occupational diseases using questionnaires: DS14 to determine psychological distress type D, Spielberger-Khanin to establish the level of personal and situational anxiety and the N.I. Vlakh questionnaire to determine subdepression. The diagnosis of arterial hypertension was established in accordance with the clinical recommendations "Arterial hypertension in adults".
Results. The incidence of arterial hypertension among the surveyed miners was 30.9%. The authors found in patients with stage 1 hypertension an increase in the frequency of overweight to 80% (p<0.01; RR=2.57; CI=1.24–5.35) and an increase in the frequency of overweight to 87.9% (p<0.001; RR=3.99; CI=1.88–8.45), fasting hyperglycemia up to 53.4% (p<0.001; HR=2.67; CI=1.7–4.18), triglyceride levels up to 63.6% (p<0.005; RR=2.16; CI=1.32–3.54) in arterial hypertension of the 2nd and 3rd stages.
The frequency of negative emotional states among patients with arterial hypertension of stage 1 had no significant differences compared with those with normal blood pressure figures.
Among the examined patients with arterial hypertension of the 2nd and 3rd stages, the authors observed an increase in the frequency of personal anxiety to 40.8%, psychological type D — to 58.9%, subdepression — to 32.4% and situational anxiety — to 23.1%. The reliability of differences in the frequency of negative emotional states in the group with normal blood pressure and hypertension of the 2nd and 3rd stages has not been established.
Limitations. The study is limited to a sample of 313 miners with occupational diseases and arterial hypertension who were treated at the Clinic of the Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases.
Conclusions. The authors revealed a significant increase in the frequency of overweight in stage 1 hypertension in coal industry workers. With arterial hypertension of stages 2 and 3, there is a significant increase in the frequency of overweight, fasting hyperglycemia and hypertriglyceridemia. There are no significant differences in the frequency of negative emotional states in patients with stage 1 arterial hypertension and those with normal blood pressure figures. With arterial hypertension of stages 2 and 3, there is a tendency to increase the frequency of personal anxiety, subdepression, situational anxiety and psychological distress type D.
Ethics. The study was conducted in compliance with the Ethical Principles of conducting medical research with human participation in accordance with the Helsinki Declaration of the World Medical Association "Ethical Principles of conducting medical research with human participation as a subject" as amended in 2013.
Physiological and hygienic assessment of the safety of the use of an industrial exoskeleton in the conditions of labor activity modeling
Shuporin E.S., Chudova E.S., Ilyenko O.V., Vaga I.N., Motkova T.Y.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2025
,
citations by CoLab: 0
|
Abstract

Introduction. The object of the study was the dynamics of the functional state of the human body when performing physical work using an industrial exoskeleton designed to unload the muscles of the back and arms when lifting, lowering, carrying and holding loads weighing up to 50 kg.
The study aims to assess the safety of using an industrial exoskeleton in labor modeling.
Materials and methods. The authors assessed the functional state of a person within the framework of the developed laboratory model of the labor activity of a potential consumer of an industrial exoskeleton using biomedical methods: medical examination, registration of biomechanics of movements and a questionnaire. The data obtained was subjected to statistical analysis.
Results. The use of an industrial exoskeleton does not affect the overall functional condition of the volunteer and does not restrict movement in the lower extremities, but it may partially restrict movement in the shoulder joints and make it difficult to perform movements in the thoracolumbar spine. The volunteer may experience local discomfort in the places where the exoskeleton parts come into contact with the skin: in the anterior surface of the wrist joint, the palmar surfaces of the hand, the anterior surface of the thigh, and the lumbar spine.
Limitations. Only 12 respondents participated in the study, which may limit the possibility of data dissemination among the general population, but statistical processing did not reveal conflicting values between the results of different participants. The authors conducted a safety study on the use of an industrial prov exoskeleton in laboratory conditions that did not fully reproduce real ones and overlooked some factors affecting an employee in production. But the conditions directly related to the use of an industrial exoskeleton were reproduced by the authors.
Conclusion. The study allows us to conclude that the use of an industrial exoskeleton is safe if the production operations performed in it are similar to the developed laboratory model. There was no negative effect on the general condition of the volunteers and the range of movements of the lower extremities. Limitations of the movements of the upper extremities and in the thoracolumbar spine were noted, related to the design characteristics of an industrial exoskeleton. It is necessary to change the features of an industrial exoskeleton, which can lead to the formation of microtrauma.
Ethics. The study was conducted in compliance with the protocol "Safety and Effectiveness study of industrial exoskeletons", approved by the Local Ethics Committee of Izmerov Research Institute of Occupational Health (Minutes No. 1 of the meeting of the Local Ethics Committee dated 01/25/2023).
The use of gas-liquid artificial lung ventilation in acute inhalation chlorine poisoning (experimental study)
Isabekov N.R., Tonshin A.A., Krikunov O.V., Bonitenko E.Y.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2025
,
citations by CoLab: 0
|
Abstract

Introduction. Currently, chlorine is widely used in industry and agriculture. There are thousands of industrial facilities located on the territory of the Russian Federation that have chlorine reserves in quantities that, in the event of an emergency, can lead to massive damage to people. Chlorine poisoning has stages of development of the toxic process with the development of toxic pulmonary edema (TPE). Respiratory therapy for TPE consists in the use of artificial lung ventilation (ALV) with positive pressure at the end of exhalation and an oxygen content in the inhaled mixture (FiO2) of at least 40%. Currently, scientists are actively developing methods of liquid artificial lung ventilation (LALV) using perfluorocarbon (PFC) liquids as an alternative to gas artificial lung ventilation (ALV), in particular, in the treatment of toxic pulmonary edema. This article shows the possibility of sequential cyclic use of liquid and gas (intermittent gas-liquid) artificial ventilation in combination with hypothermia in a model of acute inhalation chlorine damage in rats.
The study aims to evaluate the prospects of using intermittent gas-liquid artificial lung ventilation combined with hypothermia for the treatment of severe inhaled chlorine lesions.
Materials and methods. The authors have conducted a study on male Wister rats aged 4 months and weighing 192.1±2.3 g. Toxic pulmonary edema was initiated by 15-minute inhalation of chlorine at an estimated dose of 35 mg/l. The animals were anesthetized and then randomized into two groups, control and experimental (6 individuals each) based on inclusion criteria: decreased oxygen saturation (SpO2)<80 and increased heart rate (HR)>240 beats/min. The scientists performed artificial lung ventilation throughout the study in the control group. The animals of the experimental group were subjected to hypothermic liquid ventilation for an hour, after which they were switched to gas ventilation, and when SpO2 and heart rate dropped below acceptable values, the cycle was repeated. At the same time, the authors continued to ventilate with gas until the end of the experiment. Scientists used perfluorodecalin as a PFU liquid. They recorded heart rate, SpO2, rectal temperature, overall survival, and life expectancy.
Results. After inhalation, the researchers observed severe chlorine damage in all animals. 10 minutes after the start of ventilation in the animals of the control group, the authors observed an increase in saturation to 90% and a decrease in heart rate to 220–240 beats per minute, followed by 20–25 minutes. They also observed a rapid decrease in SpO2 to extremely low values and an increase in heart rate, which indicated inefficiency of ventilation and caused the development of adverse outcomes. In turn, in the experimental group, during the first 5 minutes after the start of liquid artificial lung ventilation (LALV), the researchers recorded a sharp decrease in heart rate to 104±3.5 beats/min. and an increase in SpO2 to 94±2.4%.
After switching to gas artificial lung ventilation (AVL), the time for lowering the controlled parameters below the permissible values was 45±7.9 minutes. 5 minutes after the start of the second liquid artificial ventilation session, all animals showed an increase in SpO2 and a decrease in heart rate, while the values of these indicators did not differ from the values recorded during the first session.
After the 2nd transfer to a gas ventilator, there was a short-term improvement in the studied indicators, followed by a deterioration that ended in an unfavorable outcome.
When studying survival, the authors found that the average duration of survival in the experimental group was 4.57 times longer than in the control group, and amounted to 190.0±6.3 and 41.6±3.0 minutes, respectively (p<0.001).
When assessing the amount of edematous fluid released during liquid artificial lung ventilation, the researchers found that during the experiment, that during the experiment, an average of 5.9±1.8 ml/kg was aspirated in animals of the experimental group. The average body temperature of the animals in the control group was 36.2±0.3°C. In turn, the animals of the experimental group showed a sharp decrease in temperature during the first 30 minutes of liquid artificial ventilation, by an average of 6.1±1.2°C. After that, the temperature stabilized and was in the range of 30–31°C until the death of the animals.
A pathoanatomic examination revealed that in the animals of the control group, a large amount of edematous fluid and foam was found in the respiratory tract and lungs, while in the experimental group, edematous fluid prevailed in the upper respiratory tract, and perfluorodecalin in the lower.
At the same time, the mass coefficients of the lungs of the control and experimental groups were 1.89±0.08% and 2.70±0.03%, respectively.
Limitations. There are quantitative restrictions on the presence of animals in the sample, as well as qualitative restrictions in experiments with animals with pulmonary edema after inhalation chlorine poisoning.
Conclusion. Inhalation seeding with chlorine in a 200-liter chamber with an estimated dose of 35 mg/l for 15 minutes leads to the lightning-fast development of toxic pulmonary edema in small laboratory animals (bypassing the stage of primary clinical manifestations and the latent period). The use of liquid artificial ventilation with PFDs makes it possible to evacuate edematous fluid from the lungs in case of toxic edema caused by severe inhalation chlorine poisoning, and thereby preserve gas exchange in the lungs. The use of intermittent hypothermic gas-liquid ventilation makes it possible to maintain gas exchange in the lungs in the case when conventional mechanical ventilation is ineffective and thus significantly (p<0.001) increase the survival time of laboratory animals by 4.57 times. The results obtained indicate the prospects for further development of respiratory support methods based on hypothermic ventilation as a treatment for severe forms of acute respiratory distress syndrome, in the case when traditional ventilation is no longer effective.
Ethics. Studies involving laboratory animals were conducted in compliance with the following regulations: the Helsinki Declaration of 2000. "On humane treatment of animals", Order of the USSR Ministry of Health No. 755 dated 08/12/1977 "Rules for carrying out work using experimental animals", Order of the Ministry of Health and Social Development of Russia No. 199n dated 04/01/2016 "On approval of the rules of laboratory practice". The research protocol was approved by the Ethics Committee of the Izmerov Research Institute of Occupational Health. Protocol No. 4 dated May 25, 2022.
Clinical and genetic features of toxic liver damage in workers of petrochemical enterprises
Kudoyarov E.R., Ivanova D.P., Bakirov A.B., Kalimullina D.K., Galiullina D.M., Mironova G.R.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2025
,
citations by CoLab: 0
|
Abstract
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Introduction. Harmful chemicals are often used in petrochemical production, which causes them to be in the air of the work area. Penetrating into the body of workers, chemical compounds can contribute to disorders of the body's health. The formation of chemically active metabolites during the biotransformation of xenobiotics leads to damage to the abdominal organs and causes changes in peripheral blood parameters, which can be used to search for new diagnostic markers of the effects of harmful factors on health.
The study aims to consider the prognostic possibilities of biochemical and genetic indicators for the early diagnosis of toxic liver damage in workers in the chemical industry.
Materials and methods. The experts conducted a study of the health status of 114 workers of petrochemical enterprises and they found toxic liver damage in 29 workers (cohort 1). The comparison group included 92 employees of enterprises in other industries who are not in contact with industrial chemical risk factors, of which 48 people were found to have non-alcoholic fatty liver disease (cohort 3). Scientists conducted clinical studies of the body in workers using biochemical, instrumental and genetic methods.
Results. A study of the prognostic capabilities of predictors of toxic liver damage demonstrated a good potential for biomarkers: the percentage of "comets" with fragmentation of more than 5% of DNA (cut-off=12.24%, Sen=79.3%, Spe=66.7%, AUC ROC=0.711; p<0.001), the average percentage of DNA in the tail of the "comet" (cut-off=2.95%, Sen=79.3%, Spe=60.5%, AUC ROC=0.727; p<0.001), aspartate aminotransferase (cut-off=25.5 U/L, Sen=86.2%, Spe=48.6%, AUC ROC=0.707; p<0.001), direct bilirubin (cut-off=3.05 mmol/L, Sen=72.4%, Spe=75.7%, AUC ROC=0.752; p<0.001).
Conclusion. The results of the study indicate the high prognostic capabilities of certain genetic biomarkers (the percentage of "comets" with fragmentation of more than 5% of DNA, the average percentage of DNA in the tail of the "comet") to differentiate cases of production-related toxic liver damage from cases of non-alcoholic fatty liver disease in the early stages of pathology formation.
Ethics. The study was carried out in accordance with the fundamental documents of the Russian Federation and the international principles of research ethics (minutes of the meeting of the bioethical commission of the Ufa Scientific Research Institute of Occupational Health and Human Ecology of Rospotrebnadzor No. 01-09 dated 30.09.2024).
Limitations. The results obtained are limited by the number of participants (223 workers) and the capabilities of the research methods used (clinical, sonographic, single-cell agarose gel electrophoresis, statistical, ROC analysis).
A personalized approach to the assessment of nutrition biomarkers using the example of mining workers
Mazhaeva T.V., Dubenko S.E., Chernova J.S., Sutunkova M.P., Gurvich V.B.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2025
,
citations by CoLab: 0
|
Abstract

Introduction. The use of modern OMIC technologies and traditional research methods in personalized nutrition makes it possible to provide an integrated assessment of the nutrition and health of industrial workers in order to form individual dietary recommendations.
The study aims to develop a personalized approach to the assessment of nutrition biomarkers using the example of mining workers.
Materials and methods. The study included the results of a medical examination and a survey of 40 workers at a mining enterprise in the Sverdlovsk region, and an assessment of the individual nutritional phenotype and its clinical manifestations was carried out. The levels of 60 organic acids in the urine of these workers were studied by gas chromatography mass spectrometry (LLC Chromolab), and the polymorphism of 42 genes was evaluated (LLC Basis Genotech).
Results. The nutrition of all surveyed employees of the enterprise characterizes the European model using a large number of ultra-processed, high-calorie products with a low density of vitamins and minerals. The presence of deviations in the content of organic acids in urine indicates a change in the metabolic pathways associated with the metabolism of carbohydrates, amino acids, coenzyme Q10, B vitamins, and lipoic acid. According to the results of a genetic study, more than 60% of workers revealed high genetic risks of overeating, impaired carbohydrate metabolism, increased levels of triglycerides, low-density lipoproteins (LDL), blood pressure, metabolic disorders of vitamins D and A, lactose intolerance, and decreased detoxification. According to body mass index (BMI), waist size, total cholesterol, and triglycerides, more than a third of the surveyed have metabolic syndrome.
Limitations. A small sample and a frequency-based nutrition questionnaire reduces the accuracy of the results obtained.
Conclusion. The identified markers of unbalanced nutrition, as well as the studied genetic and metabolic (dietary) profiles of employees may indicate high risks of depletion of the body's energy resources, affect detoxification processes, functional capabilities, and increase individual risks of developing metabolic syndrome, which necessitates the development of personalized dietary recommendations and correction of corporate nutrition.
Ethics. The study received permission from the local Ethics Committee of the Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor No. 5 dated 12.27.2021. All the surveyed gave voluntary informed consent.
Assessment of the risk of developing diseases characterized by high blood pressure in metallurgical workers
Gazimova V.G., Chaurina D.V., Shastin A.S., Konstantinova E.D., Maslakova T.A., Varaksin A.N., Ogorodnikova S.Y.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2025
,
citations by CoLab: 0
|
Abstract

Introduction. Mathematical models are widely used in various fields of science and practice, including medicine. The use of mathematical modeling is the only way to assess the simultaneous impact on the health of workers of many interrelated factors, including harmful production factors. Metallurgical production is one of the leading sectors of the region's economy, in which more than 70% of workers are employed in harmful working conditions. The task of using mathematical models to assess the impact of various risk factors on the development of circulatory system diseases in workers engaged in harmful working conditions remains urgent.
The study aims to build a predictive mathematical model to assess the contribution of risk factors to the development of diseases characterized by high blood pressure in metallurgical workers.
Materials and methods. The researchers examined the results of periodic medical examinations of 2,927 men in metallurgical production and their working conditions. They have created a database that includes information on the assessment of the class of working conditions, medical and biological indicators, and survey data. The authors also established the prevalence of the disease in the ICD-10 block (110–115) "Diseases characterized by high blood pressure", depending on the class of working conditions and length of service. To build a predictive model for assessing the impact of various risk factors on the development of diseases characterized by high blood pressure, the authors used the method of multiple linear regression. They determined the quality of the model by the value of the coefficient of determination.
Results. It was found that with increasing age and length of service, the rate of increase in the prevalence of diseases characterized by high blood pressure increased faster with worsening conditions. The most significant predictors of the development of diseases characterized by high blood pressure were the product of seniority on body mass index and seniority on blood glucose levels.
Limitation. A single-stage cross-sectional study was conducted, limited by the results of a one-year medical examination of employees.
Conclusion. It is advisable to use mathematical models to identify key risk factors in the development of a disease for the subsequent development of targeted medical and preventive measures aimed at its correction.
Ethics. The study was approved by the local Ethics Committee of the Yekaterinburg Medical and Scientific Center for Prevention and Health Protection of Industrial Workers of Rospotrebnadzor (conclusion No. 6 dated 12/11/2023).
N.A. Vigdorchik — is the founder of the Leningrad scientific school of occupational pathology, an outstanding scientist, teacher and public figure (on the 150th anniversary of his birth)
Grebenkov S.V.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
|
Abstract

November 17, 2024 marked the 150th anniversary of the birth of Nikolai (Nathan) Abramovich Vigdorchik, one of the founders of occupational health, the creator of the country's first department of occupational diseases and a research institute for their study in Leningrad. N.A. Vigdorchik is an iconic figure in Russian occupational pathology. The formation of occupational health as an independent discipline is associated with his name. The biography, creative and scientific path of this man are closely intertwined with the dramatic events of the historical era of the late nineteenth and early twentieth centuries, in which the pioneer scientist lived and worked.
Professor Vigdorchik can rightfully be attributed to those outstanding Russian medical scientists who actively contributed to the progressive formation and development of Russian medical science and practice in the first half of the twentieth century. His multifaceted scientific, pedagogical, therapeutic and social activities had a wide resonance, including at the state level. Thanks to his talent and vast practical experience, N.A. Vigdorchik had the ability to notice in time the shifts in medicine, economics, politics, and the social sphere taking place in our country and abroad, give them a qualified assessment and outline ways to solve topical issues, primarily in the field in which he was an outstanding specialist — occupational health and social insurance. Vigdorchik belongs to that rare breed of specialists who are commonly called encyclopedists. According to the recollections of colleagues, in addition to his brilliant abilities, he possessed excellent human qualities.
In the articles devoted to the life and work of this extraordinary man (especially in connection with the 140th anniversary), N.A. Vigdorchik's contribution to Russian science and practice is analyzed in sufficient detail. At the same time, the scale of this personality is such that not all facets of his talent are reflected in literature. In this article, the author tried to focus on information that is little known to a wide range of readers, on issues where the role and importance of professor Vigdorchik are very significant, but, in our opinion, are not fully appreciated by contemporaries.
Studying the prevalence of chronic general somatic diseases among medical workers based on a cross-sectional epidemiological study
Kuzmina L.P., Leskina L.M., Golovkova N.P., Tolmachev D.A., Osmanova P.S., Mikhailova N.S.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
|
Abstract

Introduction. Obtaining objective data on the long-term consequences of health disorders of medical workers who have suffered COVID-19 while performing professional duties is an important problem of occupational health. The establishment of background indicators of the health status of medical workers before their contact with infectious patients in the performance of professional duties is the first stage of monitoring the long-term consequences of coronavirus infection.
The study aims to assess the prevalence of chronic general somatic diseases among medical workers of various industrial and professional groups for further monitoring of their health status.
Materials and methods. The object of the study was the medical staff of the regional clinical hospital. The authors have analyzed the results of periodic medical examinations.
The total number of medical workers amounted to 495 people. Experts have formed three production and professional groups: doctors, nursing staff, and junior medical staff. The authors performed a cross-sectional epidemiological study, during which they studied the prevalence of chronic general somatic diseases in medical professionals. The reliability of the results obtained was assessed by the Student's coefficient.
Results. In the course of a cross-sectional epidemiological study, scientists found that the prevalence of chronic diseases in individual industrial and occupational groups is at the same level. In the structure of chronic general somatic diseases of medical workers, the first two places are occupied by diseases of the circulatory system and diseases of the musculoskeletal system and connective tissue.
Diseases of the endocrine system, eating disorders and metabolic disorders occupy the third place. Chronic diseases of the musculoskeletal system and connective tissue are equally common among medical workers of various professional groups and amount to 63.0±2.2 (per 100 employees).
The prevalence of chronic diseases of the circulatory system among medical workers is 50.7±2.2 per 100 employees.
When comparing the indicators between professional groups, the authors found that the prevalence of diseases of the system of this class of diseases among doctors (38.6±3.2) was significantly (p<0.05) lower compared with employees of the average (55.2±3.9) and junior (63.2±4.2) medical personnel. The prevalence of diseases of the endocrine system, eating disorders and metabolism among medical workers is 32.1±2.1 per 100 employees. At the same time, the lowest rate was noted among doctors, which is 25.9±3.1 per 100 employees and is significantly lower compared to the group of junior medical personnel (41.4±4.3).
Limitations. The study is limited to the observation period.
Conclusion. The data obtained as a result of a cross-sectional epidemiological study allowed us to establish that among doctors the prevalence of diseases of the circulatory and endocrine systems, eating disorders and metabolic disorders is significantly lower compared with medical professionals of other professional groups.
Ethics. All medical staff have given informed consent to the use of personal data for statistical processing.
Remodeling of the brachiocephalic arteries on the background of arterial hypertension in electric train drivers who have been ill with COVID-19
Gerasimidi S.K., Glukhov D.V.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
|
Abstract

Over the more than three-year period of the coronavirus pandemic, researchers have identified the relationship between cardiovascular diseases and the severity of coronavirus infection, especially in people who have had COVID-19 in a hospital setting. One of the complications of patients with coronavirus infection is an increase in blood pressure, which can lead to the formation of hypertension. It is known that arterial hypertension occupies a leading position among workers in the transport sector, including electric train drivers, in our country. The cardiovascular system of machinists is influenced by industrial risk factors (noise, vibration, psycho-emotional stress, etc.) and often non-industrial: smoking, increased body weight. The combination of these factors: coronavirus infection, industrial and non-industrial risk factors can accelerate the development of cardiovascular diseases in electric train drivers.
The study aims are the results of duplex scanning of brachiocephalic arteries in electric train drivers who have been ill with various forms of new coronavirus infection.
The authors have conducted the study on an outpatient basis among 12 male machinists aged 43.4±5.0 years working in the Central Federal District, who who have been ill with COVID-19 in the first and second quarters of 2021, and are currently continuing their work as an "electric train driver". The subjects were divided into 2 groups: the 1st group consisted of workers who had suffered a mild form of COVID-19, the 2nd group consisted of workers who had suffered a severe form of COVID-19. Scientists conducted duplex scanning of brachiocephalic arteries with color Doppler mapping for workers, and they also studied outpatient charts of workers, analyzed blood pressure data. The research was conducted in the period 2022–2023. The employees involved in the studies had risk factors such as smoking, increased body weight and high blood pressure.
Scientists have revealed higher blood pressure indicators in workers of the 2nd group (severe form), in contrast to the indicators of the 1st group (mild form), while both groups had "grade I arterial hypertension". Ultrasound examination of the brachiocephalic arteries in group 2 workers, unlike group 1 workers, revealed the initial signs of vascular remodeling at the extracranial level in the form of a diffuse increase in the echogenicity of the intima-media complex and its thickening to 1 mm in the common carotid artery, deformations of the common and internal carotid arteries, in the form of wavy C-S‑shaped tortuosity, initial ectasia of the common carotid arteries, a decrease in linear indicators of blood flow velocity, an increase in the resistance index. And also in workers who have had a severe form of coronavirus infection, when visualizing the vertebral arteries, an indirect linear course in the interosseous canal is traced, which is not observed in workers who have had a mild form of COVID-19. A study of the middle cerebral artery at the intracranial level in group 1 workers indicates the absence of hemodynamic changes, and in group 2 workers there was a decrease in speed indicators and an increase in the resistance index.
In the machinists who suffered both severe and mild forms of COVID-19, scientists established "grade I arterial hypertension", which required the appointment of antihypertensive therapy. In workers who have undergone severe COVID-19, blood pressure indicators are higher, which led to remodeling of the brachiocephalic arteries in the form of thickening of the intima-media complex of the common carotid artery, minor ectasia and the development of deformities of the carotid arteries, increased resistance to blood flow, which is not present in workers who have undergone a mild form. Workers who have developed complications in the post-СOVID period need annual duplex scanning with color Doppler mapping of the brachiocephalic arteries, which will help identify abnormalities at the extra- and intracranial level.
Limitations. There are quantitative limitations due to the number of COVID-19 patients.
Ethics. The study was approved by the local Ethics Committee of the Izmerov Research Institute of Occupational Health (Protocol No.1 dated February 16, 2022).
Elemental composition of sputum, immune status, and features of pharyngeal microbiota in workers of the anode department of a copper smelter
Karpova E.P., Bushueva T.V., Roslaya N.A., Shtin T.N., Fedoruk A.A., Gurvich V.B., Labzova A.K., Gribova Y.V., Gazimova V.G., Khlystov I.A.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
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Abstract
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The development of bronchial and pulmonary pathology depends on characteristics of the aerosols and individual resistance of the body, largely determined by the immune system, to their exposure. Mucous membranes of a healthy person are colonized by saprophytic bacteria or normal microbiota. Yet, changes in the composition and properties of the microbial landscape induced by adverse environmental factors increase the risk of inflammation and contribute to changes in the reactivity of the immune system.
The study aims to establish the immune status, microbiota of the pharyngeal mucosa, and the elemental composition of sputum, given its cellular composition, in workers of the anode department of a copper smelter.
We tested sputum culture and elemental composition, established clinical and immunological status, and analyzed pharyngeal microbiota in 28 workers of the anode department of a copper smelter. Based on the results of testing, the subjects were divided into two groups with (1) and without (2) leukocytosis (>10 cells in the field of view) detected in sputum.
We found no acute or chronic diseases of the bronchi and lungs in the examined workers. In group 1, we observed shifts in the immune response manifested by a decrease in the number of immunocompetent cells, activation of neutrophil phagocytosis, formation of reactive oxygen species in neutrophils, and displacement of normal microbiota of the oropharyngeal mucosa by opportunistic microorganisms (in 100% versus 35%, p<0.05). The elemental composition of sputum was noted for a higher frequency of iron and lead detection and increased concentrations of barium, lead, iron, arsenic, molybdenum, antimony, vanadium, and cadmium. We established a significant effect of metals contained in sputum on cellular, humoral, and local immunity.
The inflammatory bronchopulmonary response to toxic aerosol exposure is accompanied by changes in the cellular and phagocytic links of immunity, as well as in the microbial landscape on the mucous membrane of the upper respiratory tract characterized by displacement of normal biota by opportunistic microorganisms.
Limitations. This study has certain limitations associated with the small sample size and the lack of opportunity to compare metal concentrations found in sputum with reference levels.
Ethics. The study was approved by the Local Ethics Committee of the Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers (extract from the minutes of the meeting No. 8 dated 12/26/2016).
Methodological approaches to the detection of occupational cancer on the example of the Center for Occupational Pathology of the Trans-Baikal Territory
Goryaev N.I., Gorbacheva O.N., Serebryakov P.V.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
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Abstract
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Introduction. Occupational malignant neoplasms (OMN) in the structure of occupational pathology in our country for a long time occupy the last rank place, amounting to no more than 0.5%. In fact, in the Russian Federation, doctors detect from 20 to 40 cases of occupational cancer every year. The share of OMN in the structure of occupational diseases detected in the EEC countries is about 5% (up to 3,700 cases per year). The actual number of detected cases of occupational cancer in our country is several orders of magnitude lower than forecast estimates. The problem of incomplete detection of occupational cancer is quite multifaceted, largely due to the lack of vigilance of primary care doctors, the high probability of a long latent period of the disease, etc.
The study aims to find possible causes of occupational cancer based on data on newly identified cases of OMN entered into the regional cancer registry.
Materials and methods. The objects of the study were 1,359 primary cases of OMN, entered into the regional cancer registry on the basis of the Zabaikalsky regional oncological dispensary. Scientists have developed an algorithm of actions, on the basis of which they carried out the selection of cases, taking into account the localization of the disease, anamnestic information, age parameters. The authors identified cases with suspicion of the occupational nature of the disease, followed by a request for documents necessary to conduct an examination of the connection of the disease with working conditions. On the basis of the Center for Occupational Pathology of the Trans-Baikal Territory, specialists conducted a direct examination and summed up the final results.
Results. The authors selected 49 patients from 1359 cases and, after an additional request for information on the professional path, work experience in comparison with the nosological form of OMN, identified 16 cases with suspected occupational disease, of which a causal relationship between the development of the disease and working conditions was established in 12 cases, including 4 cases in patients in the post-contact period.
Limitations. The study is limited by the number of cancer cases provided for analysis.
Conclusion. The data obtained indicate that, using the example of one subject of the federation, over 10 months of work on the targeted analysis of cancer registry data, the number of cases of occupational cancer was revealed, almost comparable to the number of similar diseases detected in a year in the whole country.
Ethics. The conduct of the study did not require the conclusion of the Ethics committee.
Socio-economic efficiency of cooperation between the medical research center and the metallurgical enterprise to preserve the health of workers
Gazimova V.G., Bukhtiyarov I.V., Gurvich V.B., Sutunkova M.P., Shastin A.S., Aleshchenkova N.N., Safrygin A.V., Sozonova T.V., Mazhaeva T.V., Yarushin S.V.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
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Abstract
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Introduction. The difficult demographic situation in the country necessitates the need to improve approaches to maintaining the health of the working population and prolonging working longevity.
One of the effective forms of solving these problems is the cooperation of medical scientific organizations and business entities in organizing a complex of systemic therapeutic and preventive measures for managing employee health risk, ensuring vertical continuity and interaction between primary and specialized units, adapted to the capabilities of a medical scientific institution and enterprise.
The study aims to evaluate the socio-economic effectiveness of cooperation between a medical research center and a socially responsible business on the example of a large metallurgical enterprise in the Sverdlovsk region.
Materials and methods. Specialists analyzed the results of a set of therapeutic and preventive measures implemented in Uralelectromed JSC together with the Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers (YMRC) for the period 2014–2023. The authors conducted a retrospective analysis of the occupational morbidity of employees at the enterprise for the period from 2004 to 2023 and morbidity with temporary disability (MTD) for certain nosological forms in the period from 2019 to 2023. The scientists assessed the economic efficiency of the therapeutic and preventive measures carried out at the enterprise, using the methodological recommendations adopted in the Rospotrebnadzor system.
Results. The implementation of a set of therapeutic and preventive measures for employees of Uralelectromed JSC together with YMRC allowed to reduce the proportion of people with medical contraindications to work from 8.9% in 2014 to 0.8% in 2023, the number of cases and days of morbidity with temporary disability due to hypertension by 1.9 and 2.1 times, respectively, to ensure sustainable the tendency to decrease the level of newly identified occupational morbidity, to improve the indicators characterizing the fatigue and efficiency of workers (p=0.001). The prevented economic losses as a result of the introduction of systemic therapeutic and preventive measures to manage risks to the health of employees of Uralelectromed JSC amounted to more than 25,898.0 thousand rubles per year.
Limitations. The study of morbidity with temporary disability is limited to the block of diagnoses of ICD-10 (I10–I15) "Diseases characterized by high blood pressure".
Conclusion. The introduction of a complex of systemic therapeutic and preventive measures for managing employee health risk at a metallurgical enterprise determines a significant socio-economic effect from the joint activities of a medical scientific organization and a socially responsible business, which allows us to propose this set of measures for replication at the corporate and regional levels.
Ethics. The study was approved by the local Ethics Committee of the Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers (conclusion No. 6 dated 12/11/2023).
The use of a medical information system in the detection of occupational oncological pathology in the Krasnoyarsk Territory
Zakharinskaya O.N., Korchagin E.E., Cherkashin O.A., Goryaev D.V., Fadeev A.G., Serebryakov P.V., Strizhakov L.A.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
|
Abstract
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Introduction. The article tells about the consistently low levels of detection of occupational malignant neoplasms (OMN) for many years in the Russian Federation. This creates a picture of imaginary well-being, which does not allow us to objectively characterize the real risks to public health associated with exposure to carcinogens in the workplace.
The study aims to develop and practically test an algorithm for detecting occupational malignant neoplasms using a medical information system.
Materials and methods. On the basis of the medical information system used in the Krasnoyarsk Regional Center of Occupational Pathology ("Regional Clinical Hospital"), specialists have developed and put into practice a system for detecting occupational malignant diseases. The combination of information flows from the main institutions providing medical care in the field of Oncology, the selection of patient data using information about the place of work, probable professional contact with carcinogens (according to data provided by the Office of Rospotrebnadzor in the Krasnoyarsk Territory), allowed us to analyze the information received about patients.
Results. In case of a positive decision of the commission on suspicion of the professional nature of the disease, taking into account the professional route, the localization of the OMN and the current list of occupational diseases, the specialists initiated a procedure for examining the connection of the disease with the profession. During the three quarters of 2024, the researchers analyzed 437 cases of diseases with subsequent registration of sanitary and hygienic characteristics in 25 cases. Of the selected cases, the link between the disease and the profession has currently been established in 9 cases, 10 cases are in the works at the time of writing. In other cases, specialists recognized the diseases as common.
Limitations. The study was limited by the time frame and the number of identified cases of neoplasms submitted for detailed consideration.
Conclusion. The implemented system made it possible in less than a year to identify the number of cases of occupational cancer in only one subject of the Federation (Krasnoyarsk Territory), corresponding to almost half of the number of occupational cancers detected in the whole country. The use of a medical information system expands the possibilities of diagnosing occupational diseases.
Ethics. The conducted research did not require the conclusion of the Ethics Committee.
Using the Work Ability Index (WAI) to assess the possibility of returning to the profession after treatment
Trubetskov A.D., Makhonko M.N.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
|
Abstract
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The use of the index of working capacity in medicine and occupational safety makes it possible to assess the individual working capacity of workers, to predict the possibility of retaining workers in the profession. A survey using the ability to work index helps to identify personnel who have an increased risk of dismissal and absence from work related to health and poor work results. Various pathological conditions can take an employee out of work for different periods, but it is extremely important to understand whether it is possible to preserve the employee's specialty and the prospects for his socialization. The disease changes not only the physical, but also the psycho-emotional state of the employee. The authors presented an analysis of modern scientific literature on the international experience of using the ability to work index to predict the possibility of returning to work in the specialty after treatment of diseases, rehabilitation. The work ability index can be used as a criterion for the effectiveness of treatment and rehabilitation after illness and subsequent employment. The link between quality of life and returning to work is of great importance. The ability to work of employees with various diseases, who have received different types of treatment, including surgical interventions, chemoradiotherapy and returned to work, is reduced compared with healthy employees. Recovery depends on the stage of the disease, the type of treatment and concomitant pathology. The risk of early retirement increases in the first years after cancer treatment. Professional rehabilitation promotes the fullest integration of an employee into society through professional self-realization.
Cardiorespiratory system of massage therapists when performing a dosed massage procedure
Garnov I.O., Loginova T.P., Bojko E.R.
Q3
Russian Journal of Occupational Health and Industrial Ecology (Meditsina truda i promyshlennaya ekologiya)
,
2024
,
citations by CoLab: 0
|
Abstract
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The article tells about the presentation of a number of studies on the effect of massage procedures on the physiological, biochemical and psychological status of a person, while work on evaluating the functional indicators of massage therapists during the procedure is rare.
The study aims to determine the functional state of the cardiorespiratory system (CRS) of massage specialists in the dynamics of performing a 30-minute back massage session.
The object of the study was 10 male massage therapists (age 36.0 (29.0;42.0); BMI 24.7(23.3;31.3). The study consisted in performing a classical back massage procedure for 30 minutes according to a generally accepted technique using six massage techniques. To determine the functional state during the work of specialists, an ergospirometric system and measurement of blood pressure (BP) by the Korotkiy method were used.
During the massage procedure, specialists noted an increase in metabolic parameters, oxygen consumption (OC), respiratory coefficient (RC) and energy consumption, as well as blood pressure by the 30th minute of the procedure.
When performing a 30-minute back massage, massage specialists significantly mobilize the links of the cardiorespiratory system. At the end of the procedure, there is an increase in blood pressure. However, the maximum increase in the parameters of the cardiorespiratory system occurs when performing a shock vibration reception.
Limitations. Due to the small sample of the group, it is not possible to statistically reliably assess the significance of changes in some indicators.
Ethics. The protocol of the experiment corresponded to the Helsinki Declaration. The study was developed and conducted in accordance with the methodological guidelines of the Local Scientific Research Committee on Bioethics of the Institute of Physiology of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences.
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