Hospital General Universitario de Elche

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Short name

HGUE

Country, city

Spain, Elche

01jmsem62

Organization website

Publications

1 967

Citations

24 013

h-index

Top-3 journals

Clinical and Translational Oncology (98 publications)

Journal of Clinical Oncology (82 publications)

Annals of Oncology (63 publications)

Top-3 organizations

Miguel Hernández University of Elche (439 publications)

Hospital Universitario Ramón y Cajal (306 publications)

Hospital General Universitario de Alicante Doctor Balmis (296 publications)

Top-3 foreign organizations

Harvard University (22 publications)

National Cancer Institute (22 publications)

University of Maryland, Baltimore (16 publications)

Top-1 researchers by h-index

Benitez Fuentes Javier David

🥼 🤝

39 publications, 195 citations, 17 reviews

h-index: 4

Most cited in 5 years

Found

Publication title

Publisher

Journal

Countries

Found

Since 1995

Total publications

1967

Total citations

24013

Citations per publication

12.21

Average publications per year

63.45

Average authors per publication

14.67

h-index

Metrics description

h-index

A scientist has an h-index if h of his N publications are cited at least h times each, while the remaining (N - h) publications are cited no more than h times each.

https://www.pnas.org/doi/full/10.1073/pnas.0507655102

Top-30

Fields of science

	50 100 150 200 250 300 350 400 450 500
General Medicine	General Medicine, 459, 23.34% General Medicine 459 publications, 23.34%
Oncology	Oncology, 428, 21.76% Oncology 428 publications, 21.76%
Cancer Research	Cancer Research, 299, 15.2% Cancer Research 299 publications, 15.2%
Infectious Diseases	Infectious Diseases, 161, 8.19% Infectious Diseases 161 publications, 8.19%
Microbiology (medical)	Microbiology (medical), 160, 8.13% Microbiology (medical) 160 publications, 8.13%
Surgery	Surgery, 119, 6.05% Surgery 119 publications, 6.05%
Pharmacology (medical)	Pharmacology (medical), 98, 4.98% Pharmacology (medical) 98 publications, 4.98%
Gastroenterology	Gastroenterology, 97, 4.93% Gastroenterology 97 publications, 4.93%
Hematology	Hematology, 78, 3.97% Hematology 78 publications, 3.97%
Pharmacology	Pharmacology, 60, 3.05% Pharmacology 60 publications, 3.05%
Pulmonary and Respiratory Medicine	Pulmonary and Respiratory Medicine, 59, 3% Pulmonary and Respiratory Medicine 59 publications, 3%
Neurology (clinical)	Neurology (clinical), 56, 2.85% Neurology (clinical) 56 publications, 2.85%
Public Health, Environmental and Occupational Health	Public Health, Environmental and Occupational Health, 52, 2.64% Public Health, Environmental and Occupational Health 52 publications, 2.64%
Immunology and Allergy	Immunology and Allergy, 51, 2.59% Immunology and Allergy 51 publications, 2.59%
Immunology	Immunology, 45, 2.29% Immunology 45 publications, 2.29%
Critical Care and Intensive Care Medicine	Critical Care and Intensive Care Medicine, 38, 1.93% Critical Care and Intensive Care Medicine 38 publications, 1.93%
Cardiology and Cardiovascular Medicine	Cardiology and Cardiovascular Medicine, 37, 1.88% Cardiology and Cardiovascular Medicine 37 publications, 1.88%
Hepatology	Hepatology, 36, 1.83% Hepatology 36 publications, 1.83%
Multidisciplinary	Multidisciplinary, 35, 1.78% Multidisciplinary 35 publications, 1.78%
Pathology and Forensic Medicine	Pathology and Forensic Medicine, 34, 1.73% Pathology and Forensic Medicine 34 publications, 1.73%
Molecular Biology	Molecular Biology, 32, 1.63% Molecular Biology 32 publications, 1.63%
Genetics	Genetics, 32, 1.63% Genetics 32 publications, 1.63%
Urology	Urology, 29, 1.47% Urology 29 publications, 1.47%
Health Policy	Health Policy, 28, 1.42% Health Policy 28 publications, 1.42%
Endocrinology, Diabetes and Metabolism	Endocrinology, Diabetes and Metabolism, 27, 1.37% Endocrinology, Diabetes and Metabolism 27 publications, 1.37%
Neurology	Neurology, 25, 1.27% Neurology 25 publications, 1.27%
Psychiatry and Mental health	Psychiatry and Mental health, 25, 1.27% Psychiatry and Mental health 25 publications, 1.27%
Dermatology	Dermatology, 24, 1.22% Dermatology 24 publications, 1.22%
Cellular and Molecular Neuroscience	Cellular and Molecular Neuroscience, 23, 1.17% Cellular and Molecular Neuroscience 23 publications, 1.17%
Rheumatology	Rheumatology, 23, 1.17% Rheumatology 23 publications, 1.17%
	50 100 150 200 250 300 350 400 450 500

Journals

	10 20 30 40 50 60 70 80 90 100
Clinical and Translational Oncology	Clinical and Translational Oncology, 98, 4.98% Clinical and Translational Oncology 98 publications, 4.98%
Journal of Clinical Oncology	Journal of Clinical Oncology, 82, 4.17% Journal of Clinical Oncology 82 publications, 4.17%
Annals of Oncology	Annals of Oncology, 63, 3.2% Annals of Oncology 63 publications, 3.2%
Cirugia Espanola	Cirugia Espanola, 60, 3.05% Cirugia Espanola 60 publications, 3.05%
Enfermedades Infecciosas y Microbiologia Clinica	Enfermedades Infecciosas y Microbiologia Clinica, 58, 2.95% Enfermedades Infecciosas y Microbiologia Clinica 58 publications, 2.95%
Archivos de Bronconeumologia	Archivos de Bronconeumologia, 43, 2.19% Archivos de Bronconeumologia 43 publications, 2.19%
Medicina Clinica	Medicina Clinica, 41, 2.08% Medicina Clinica 41 publications, 2.08%
Journal of Crohn's and Colitis	Journal of Crohn's and Colitis, 34, 1.73% Journal of Crohn's and Colitis 34 publications, 1.73%
PLoS ONE	PLoS ONE, 28, 1.42% PLoS ONE 28 publications, 1.42%
Revista Clinica Espanola	Revista Clinica Espanola, 27, 1.37% Revista Clinica Espanola 27 publications, 1.37%
Medicina Intensiva	Medicina Intensiva, 25, 1.27% Medicina Intensiva 25 publications, 1.27%
Cancer Research	Cancer Research, 24, 1.22% Cancer Research 24 publications, 1.22%
Actas Urologicas Espanolas	Actas Urologicas Espanolas, 23, 1.17% Actas Urologicas Espanolas 23 publications, 1.17%
Cirugía Española (English Edition)	Cirugía Española (English Edition), 22, 1.12% Cirugía Española (English Edition) 22 publications, 1.12%
Archivos de la Sociedad Espanola de Oftalmologia	Archivos de la Sociedad Espanola de Oftalmologia, 20, 1.02% Archivos de la Sociedad Espanola de Oftalmologia 20 publications, 1.02%
Journal of Antimicrobial Chemotherapy	Journal of Antimicrobial Chemotherapy, 20, 1.02% Journal of Antimicrobial Chemotherapy 20 publications, 1.02%
Journal of Clinical Medicine	Journal of Clinical Medicine, 20, 1.02% Journal of Clinical Medicine 20 publications, 1.02%
Clinical Infectious Diseases	Clinical Infectious Diseases, 17, 0.86% Clinical Infectious Diseases 17 publications, 0.86%
Gastroenterologia y Hepatologia	Gastroenterologia y Hepatologia, 17, 0.86% Gastroenterologia y Hepatologia 17 publications, 0.86%
Endoscopy	Endoscopy, 15, 0.76% Endoscopy 15 publications, 0.76%
Journal of Thoracic Oncology	Journal of Thoracic Oncology, 15, 0.76% Journal of Thoracic Oncology 15 publications, 0.76%
European Journal of Hospital Pharmacy	European Journal of Hospital Pharmacy, 15, 0.76% European Journal of Hospital Pharmacy 15 publications, 0.76%
Farmacia Hospitalaria	Farmacia Hospitalaria, 14, 0.71% Farmacia Hospitalaria 14 publications, 0.71%
British Journal of Surgery	British Journal of Surgery, 14, 0.71% British Journal of Surgery 14 publications, 0.71%
Medicina Intensiva (English Edition)	Medicina Intensiva (English Edition), 14, 0.71% Medicina Intensiva (English Edition) 14 publications, 0.71%
Cancers	Cancers, 13, 0.66% Cancers 13 publications, 0.66%
Archivos de la Sociedad Española de Oftalmología (English Edition)	Archivos de la Sociedad Española de Oftalmología (English Edition), 13, 0.66% Archivos de la Sociedad Española de Oftalmología (English Edition) 13 publications, 0.66%
Revista Espanola de Cardiologia	Revista Espanola de Cardiologia, 12, 0.61% Revista Espanola de Cardiologia 12 publications, 0.61%
Actas Dermo-Sifiliograficas	Actas Dermo-Sifiliograficas, 12, 0.61% Actas Dermo-Sifiliograficas 12 publications, 0.61%
European Journal of Clinical Microbiology and Infectious Diseases	European Journal of Clinical Microbiology and Infectious Diseases, 11, 0.56% European Journal of Clinical Microbiology and Infectious Diseases 11 publications, 0.56%
	10 20 30 40 50 60 70 80 90 100

Publishers

	100 200 300 400 500 600 700 800 900 1000
Elsevier	Elsevier, 931, 47.33% Elsevier 931 publications, 47.33%
Springer Nature	Springer Nature, 284, 14.44% Springer Nature 284 publications, 14.44%
Wiley	Wiley, 114, 5.8% Wiley 114 publications, 5.8%
Oxford University Press	Oxford University Press, 104, 5.29% Oxford University Press 104 publications, 5.29%
American Society of Clinical Oncology (ASCO)	American Society of Clinical Oncology (ASCO), 85, 4.32% American Society of Clinical Oncology (ASCO) 85 publications, 4.32%
MDPI	MDPI, 79, 4.02% MDPI 79 publications, 4.02%
SAGE	SAGE, 37, 1.88% SAGE 37 publications, 1.88%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 36, 1.83% American Association for Cancer Research (AACR) 36 publications, 1.83%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 32, 1.63% Public Library of Science (PLoS) 32 publications, 1.63%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 30, 1.53% Ovid Technologies (Wolters Kluwer Health) 30 publications, 1.53%
BMJ	BMJ, 26, 1.32% BMJ 26 publications, 1.32%
Georg Thieme Verlag KG	Georg Thieme Verlag KG, 25, 1.27% Georg Thieme Verlag KG 25 publications, 1.27%
Taylor & Francis	Taylor & Francis, 23, 1.17% Taylor & Francis 23 publications, 1.17%
Frontiers Media S.A.	Frontiers Media S.A., 19, 0.97% Frontiers Media S.A. 19 publications, 0.97%
S. Karger AG	S. Karger AG, 17, 0.86% S. Karger AG 17 publications, 0.86%
Mary Ann Liebert	Mary Ann Liebert, 13, 0.66% Mary Ann Liebert 13 publications, 0.66%
American Society for Microbiology	American Society for Microbiology, 12, 0.61% American Society for Microbiology 12 publications, 0.61%
American Medical Association (AMA)	American Medical Association (AMA), 11, 0.56% American Medical Association (AMA) 11 publications, 0.56%
IOS Press	IOS Press, 8, 0.41% IOS Press 8 publications, 0.41%
Walter de Gruyter	Walter de Gruyter, 7, 0.36% Walter de Gruyter 7 publications, 0.36%
IMR Press	IMR Press, 7, 0.36% IMR Press 7 publications, 0.36%
Cambridge University Press	Cambridge University Press, 5, 0.25% Cambridge University Press 5 publications, 0.25%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 4, 0.2% Bentham Science Publishers Ltd. 4 publications, 0.2%
AME Publishing Company	AME Publishing Company, 4, 0.2% AME Publishing Company 4 publications, 0.2%
Society for Translational Oncology	Society for Translational Oncology, 4, 0.2% Society for Translational Oncology 4 publications, 0.2%
Microbiology Society	Microbiology Society, 3, 0.15% Microbiology Society 3 publications, 0.15%
Massachusetts Medical Society	Massachusetts Medical Society, 3, 0.15% Massachusetts Medical Society 3 publications, 0.15%
Hindawi Limited	Hindawi Limited, 3, 0.15% Hindawi Limited 3 publications, 0.15%
Social Science Electronic Publishing	Social Science Electronic Publishing, 3, 0.15% Social Science Electronic Publishing 3 publications, 0.15%
Environmental Health Perspectives	Environmental Health Perspectives, 3, 0.15% Environmental Health Perspectives 3 publications, 0.15%
	100 200 300 400 500 600 700 800 900 1000

With other organizations

With foreign organizations

	5 10 15 20 25
Harvard University	Harvard University, 22, 1.12% Harvard University 22 publications, 1.12%
National Cancer Institute	National Cancer Institute, 22, 1.12% National Cancer Institute 22 publications, 1.12%
University of Maryland, Baltimore	University of Maryland, Baltimore, 16, 0.81% University of Maryland, Baltimore 16 publications, 0.81%
French Institute of Health and Medical Research	French Institute of Health and Medical Research, 15, 0.76% French Institute of Health and Medical Research 15 publications, 0.76%
Pontificia Universidad Católica de Chile	Pontificia Universidad Católica de Chile, 13, 0.66% Pontificia Universidad Católica de Chile 13 publications, 0.66%
Karolinska Institute	Karolinska Institute, 12, 0.61% Karolinska Institute 12 publications, 0.61%
Istituti di Ricovero e Cura a Carattere Scientifico	Istituti di Ricovero e Cura a Carattere Scientifico, 12, 0.61% Istituti di Ricovero e Cura a Carattere Scientifico 12 publications, 0.61%
University of Gothenburg	University of Gothenburg, 10, 0.51% University of Gothenburg 10 publications, 0.51%
Sorbonne University	Sorbonne University, 10, 0.51% Sorbonne University 10 publications, 0.51%
University College London	University College London, 9, 0.46% University College London 9 publications, 0.46%
University Hospital of Giessen and Marburg	University Hospital of Giessen and Marburg, 9, 0.46% University Hospital of Giessen and Marburg 9 publications, 0.46%
Queen Mary University of London	Queen Mary University of London, 8, 0.41% Queen Mary University of London 8 publications, 0.41%
Royal Liverpool University Hospital	Royal Liverpool University Hospital, 8, 0.41% Royal Liverpool University Hospital 8 publications, 0.41%
Cornell University	Cornell University, 8, 0.41% Cornell University 8 publications, 0.41%
Institute of Nanotechnology	Institute of Nanotechnology, 8, 0.41% Institute of Nanotechnology 8 publications, 0.41%
University of Calabria	University of Calabria, 8, 0.41% University of Calabria 8 publications, 0.41%
Memorial Sloan Kettering Cancer Center	Memorial Sloan Kettering Cancer Center, 8, 0.41% Memorial Sloan Kettering Cancer Center 8 publications, 0.41%
Technical University of Munich	Technical University of Munich, 7, 0.36% Technical University of Munich 7 publications, 0.36%
Sahlgrenska University Hospital	Sahlgrenska University Hospital, 7, 0.36% Sahlgrenska University Hospital 7 publications, 0.36%
University of Milan	University of Milan, 7, 0.36% University of Milan 7 publications, 0.36%
Medical University of Vienna	Medical University of Vienna, 7, 0.36% Medical University of Vienna 7 publications, 0.36%
University of Ferrara	University of Ferrara, 7, 0.36% University of Ferrara 7 publications, 0.36%
University of Illinois at Chicago	University of Illinois at Chicago, 7, 0.36% University of Illinois at Chicago 7 publications, 0.36%
Dana-Farber Cancer Institute	Dana-Farber Cancer Institute, 7, 0.36% Dana-Farber Cancer Institute 7 publications, 0.36%
Queen's University Belfast	Queen's University Belfast, 7, 0.36% Queen's University Belfast 7 publications, 0.36%
Aristotle University of Thessaloniki	Aristotle University of Thessaloniki, 7, 0.36% Aristotle University of Thessaloniki 7 publications, 0.36%
University of Texas MD Anderson Cancer Center	University of Texas MD Anderson Cancer Center, 7, 0.36% University of Texas MD Anderson Cancer Center 7 publications, 0.36%
Katholieke Universiteit Leuven	Katholieke Universiteit Leuven, 6, 0.31% Katholieke Universiteit Leuven 6 publications, 0.31%
University of Verona	University of Verona, 6, 0.31% University of Verona 6 publications, 0.31%
University of Modena and Reggio Emilia	University of Modena and Reggio Emilia, 6, 0.31% University of Modena and Reggio Emilia 6 publications, 0.31%
	5 10 15 20 25

With other countries

	20 40 60 80 100 120
USA	USA, 119, 6.05% USA 119 publications, 6.05%
Italy	Italy, 69, 3.51% Italy 69 publications, 3.51%
United Kingdom	United Kingdom, 62, 3.15% United Kingdom 62 publications, 3.15%
France	France, 50, 2.54% France 50 publications, 2.54%
Germany	Germany, 42, 2.14% Germany 42 publications, 2.14%
Belgium	Belgium, 31, 1.58% Belgium 31 publications, 1.58%
Switzerland	Switzerland, 28, 1.42% Switzerland 28 publications, 1.42%
Netherlands	Netherlands, 22, 1.12% Netherlands 22 publications, 1.12%
Chile	Chile, 21, 1.07% Chile 21 publications, 1.07%
Sweden	Sweden, 20, 1.02% Sweden 20 publications, 1.02%
Canada	Canada, 16, 0.81% Canada 16 publications, 0.81%
Greece	Greece, 13, 0.66% Greece 13 publications, 0.66%
Portugal	Portugal, 12, 0.61% Portugal 12 publications, 0.61%
Austria	Austria, 12, 0.61% Austria 12 publications, 0.61%
Brazil	Brazil, 11, 0.56% Brazil 11 publications, 0.56%
China	China, 10, 0.51% China 10 publications, 0.51%
Mexico	Mexico, 10, 0.51% Mexico 10 publications, 0.51%
Ecuador	Ecuador, 10, 0.51% Ecuador 10 publications, 0.51%
Australia	Australia, 9, 0.46% Australia 9 publications, 0.46%
Ireland	Ireland, 9, 0.46% Ireland 9 publications, 0.46%
Ethiopia	Ethiopia, 9, 0.46% Ethiopia 9 publications, 0.46%
Czech Republic	Czech Republic, 8, 0.41% Czech Republic 8 publications, 0.41%
Argentina	Argentina, 7, 0.36% Argentina 7 publications, 0.36%
Denmark	Denmark, 7, 0.36% Denmark 7 publications, 0.36%
Poland	Poland, 7, 0.36% Poland 7 publications, 0.36%
Turkey	Turkey, 7, 0.36% Turkey 7 publications, 0.36%
Colombia	Colombia, 6, 0.31% Colombia 6 publications, 0.31%
Republic of Korea	Republic of Korea, 6, 0.31% Republic of Korea 6 publications, 0.31%
Japan	Japan, 6, 0.31% Japan 6 publications, 0.31%
	20 40 60 80 100 120

We do not take into account publications without a DOI.
Statistics recalculated daily.
Publications published earlier than 1995 are ignored in the statistics.
The horizontal charts show the 30 top positions.
Journals quartiles values are relevant at the moment.

Science degree

Academy membership

Research interests

Skills

	50 100 150 200 250 300 350 400 450
Miguel Hernández University of Elche	Miguel Hernández University of Elche, 439, 22.32% Miguel Hernández University of Elche 439 publications, 22.32%
Hospital Universitario Ramón y Cajal	Hospital Universitario Ramón y Cajal, 306, 15.56% Hospital Universitario Ramón y Cajal 306 publications, 15.56%
Hospital General Universitario de Alicante Doctor Balmis	Hospital General Universitario de Alicante Doctor Balmis, 296, 15.05% Hospital General Universitario de Alicante Doctor Balmis 296 publications, 15.05%
Virgen del Rocío University Hospital	Virgen del Rocío University Hospital, 228, 11.59% Virgen del Rocío University Hospital 228 publications, 11.59%
Hospital de la Santa Creu i Sant Pau	Hospital de la Santa Creu i Sant Pau, 223, 11.34% Hospital de la Santa Creu i Sant Pau 223 publications, 11.34%
Instituto de Salud Carlos III	Instituto de Salud Carlos III, 191, 9.71% Instituto de Salud Carlos III 191 publications, 9.71%
Reina Sofia Hospital	Reina Sofia Hospital, 184, 9.35% Reina Sofia Hospital 184 publications, 9.35%
Marqués de Valdecilla University Hospital	Marqués de Valdecilla University Hospital, 183, 9.3% Marqués de Valdecilla University Hospital 183 publications, 9.3%
Hospital Universitario La Paz	Hospital Universitario La Paz, 182, 9.25% Hospital Universitario La Paz 182 publications, 9.25%
Hospital Clínic de Barcelona	Hospital Clínic de Barcelona, 174, 8.85% Hospital Clínic de Barcelona 174 publications, 8.85%
Miguel Servet University Hospital	Miguel Servet University Hospital, 174, 8.85% Miguel Servet University Hospital 174 publications, 8.85%
Hospital General Universitario Gregorio Marañón	Hospital General Universitario Gregorio Marañón, 170, 8.64% Hospital General Universitario Gregorio Marañón 170 publications, 8.64%
Catalan Institute of Oncology	Catalan Institute of Oncology, 167, 8.49% Catalan Institute of Oncology 167 publications, 8.49%
Hospital Clínico San Carlos	Hospital Clínico San Carlos, 159, 8.08% Hospital Clínico San Carlos 159 publications, 8.08%
Hospital San Juan de Alicante	Hospital San Juan de Alicante, 150, 7.63% Hospital San Juan de Alicante 150 publications, 7.63%
Donostia University Hospital	Donostia University Hospital, 145, 7.37% Donostia University Hospital 145 publications, 7.37%
Complexo Hospitalario Universitario A Coruña	Complexo Hospitalario Universitario A Coruña, 144, 7.32% Complexo Hospitalario Universitario A Coruña 144 publications, 7.32%
Hospital Universitario de La Princesa	Hospital Universitario de La Princesa, 143, 7.27% Hospital Universitario de La Princesa 143 publications, 7.27%
Hospital Clínico Universitario de Valencia	Hospital Clínico Universitario de Valencia, 141, 7.17% Hospital Clínico Universitario de Valencia 141 publications, 7.17%
Hospital Universitari Germans Trias i Pujol	Hospital Universitari Germans Trias i Pujol, 141, 7.17% Hospital Universitari Germans Trias i Pujol 141 publications, 7.17%
Complejo Hospitalario de Salamanca	Complejo Hospitalario de Salamanca, 139, 7.07% Complejo Hospitalario de Salamanca 139 publications, 7.07%
Hospital Del Mar	Hospital Del Mar, 135, 6.86% Hospital Del Mar 135 publications, 6.86%
Hospital General Universitario De Valencia	Hospital General Universitario De Valencia, 125, 6.35% Hospital General Universitario De Valencia 125 publications, 6.35%
Hospital Clínico Universitario Lozano Blesa	Hospital Clínico Universitario Lozano Blesa, 125, 6.35% Hospital Clínico Universitario Lozano Blesa 125 publications, 6.35%
Centro de Investigación Biomédica en Red de Cáncer	Centro de Investigación Biomédica en Red de Cáncer, 118, 6% Centro de Investigación Biomédica en Red de Cáncer 118 publications, 6%
Hospital Arnau de Vilanova	Hospital Arnau de Vilanova, 116, 5.9% Hospital Arnau de Vilanova 116 publications, 5.9%
Alicante Institute for Health and Biomedical Research	Alicante Institute for Health and Biomedical Research, 111, 5.64% Alicante Institute for Health and Biomedical Research 111 publications, 5.64%
Puerta de Hierro Majadahonda University Hospital	Puerta de Hierro Majadahonda University Hospital, 109, 5.54% Puerta de Hierro Majadahonda University Hospital 109 publications, 5.54%
Vall d'Hebron University Hospital	Vall d'Hebron University Hospital, 108, 5.49% Vall d'Hebron University Hospital 108 publications, 5.49%
Hospital Universitario Fundación Jiménez Díaz	Hospital Universitario Fundación Jiménez Díaz, 107, 5.44% Hospital Universitario Fundación Jiménez Díaz 107 publications, 5.44%
	50 100 150 200 250 300 350 400 450