Phytotherapy Research

, volume 14 , issue 3 , pages 160-162

Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis

Yu O Teselkin ¹

I V Babenkova ¹

V K Kolhir ²

A I Baginskaya ²

N A Tjukavkina ³

Yu A Kolesnik ³

I A Selivanova ³

A A Eichholz ⁴

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Biophysics, Russian State Medical University, Ostrovityanova Street 1, Moscow 117869, Russia. |

Department of Medicine, Institute of Plant Substances, Grin Street 7, Moscow 113628, Russia |

Department of Organic Chemistry, Moscow Medical Academy, 5th Parkovaya Street 21, Moscow 105043, Russia |

⁴

Department of Physiology and Biophysics, UMDNJ‐Johnson Medical School, P.O. Box 431, Tracys Landing, MD 20779, USA |

Publication type: Journal Article

Publication date: 2000-05-01

Wiley

Phytotherapy Research

scimago Q1

wos Q1

SJR: 1.477

CiteScore: 14.4

Impact factor: 6.3

ISSN: 0951418X, 10991573

DOI: 10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y

Copy DOI

PubMed ID: 10815007

Pharmacology

Abstract

The antioxidant effect of dihydroquercetin (DHQ) was studied in Wistar rats with experimental hepatitis, caused by tetrachloromethane (CCl(4)). Animals were divided into three groups: intact (n = 9); control (n = 9) which received CCl(4) subcutaneously for 4 days (4 mL/kg); and experimental (n = 9) which received DHQ (100 mg/kg) for 4 days prior to the first administration of CCl(4) and during the course of the subsequent 14 days. DHQ was intubated per os, using a water crystalline suspension. The content of products of lipid peroxidation, reacting with thiobarbituric acid in the serum and liver of the control animals, was increased by more than 1.5 fold compared with the intact and experimental animals (p < 0.01). The blood plasma antioxidant activity of the control animals was 1.8 to 2 times lower than that of experimental and intact animals (p < 0.01) It is suggested that the data obtained are dependent on the anti-oxidant properties of DHQ.

Found

2 citations

Lysenko Liudmila

62 publications, 336 citations, 74 reviews

h-index: 10

Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences

Karelian Research Centre of the Russian Academy of Sciences

2 citations

Suhovskaya Irina

🥼

PhD in Biological/biomedical sciences

40 publications, 140 citations, 15 reviews

h-index: 7

Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences

Petrozavodsk State University

2 citations

Terehov Roman

PhD in Pharmacy

29 publications, 615 citations

h-index: 10

Sechenov First Moscow State Medical University

Research interests

Natural polyphenols

Pharmaceutical Chemistry

Polymorphism

2 citations

Selivanova Irina

DSc in Pharmacy, professor

43 publications, 778 citations

h-index: 12

Sechenov First Moscow State Medical University

1 citation

Olicheva Vera

5 publications, 10 citations

h-index: 2

Sechenov First Moscow State Medical University

Research interests

Oxidative stress

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Teselkin Yu. O. et al. Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis // Phytotherapy Research. 2000. Vol. 14. No. 3. pp. 160-162.

GOST all authors (up to 50) Copy

Teselkin Yu. O., Babenkova I. V., Kolhir V. K., Baginskaya A. I., Tjukavkina N. A., Kolesnik Yu. A., Selivanova I. A., Eichholz A. A. Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis // Phytotherapy Research. 2000. Vol. 14. No. 3. pp. 160-162.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y

UR - https://doi.org/10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y

TI - Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis

T2 - Phytotherapy Research

AU - Teselkin, Yu O

AU - Babenkova, I V

AU - Kolhir, V K

AU - Baginskaya, A I

AU - Tjukavkina, N A

AU - Kolesnik, Yu A

AU - Selivanova, I A

AU - Eichholz, A A

PY - 2000

DA - 2000/05/01

PB - Wiley

SP - 160-162

IS - 3

VL - 14

PMID - 10815007

SN - 0951-418X

SN - 1099-1573

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2000_Teselkin,

author = {Yu O Teselkin and I V Babenkova and V K Kolhir and A I Baginskaya and N A Tjukavkina and Yu A Kolesnik and I A Selivanova and A A Eichholz},

title = {Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis},

journal = {Phytotherapy Research},

year = {2000},

volume = {14},

publisher = {Wiley},

month = {may},

url = {https://doi.org/10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y},

number = {3},

pages = {160--162},

doi = {10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y}

}

MLA

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MLA Copy

Teselkin, Yu. O., et al. “Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis.” Phytotherapy Research, vol. 14, no. 3, May. 2000, pp. 160-162. https://doi.org/10.1002/(sici)1099-1573(200005)14:3<160::aid-ptr555>3.0.co;2-y.