Archiv der Pharmazie, volume 331, issue 9, pages 273-278
2-Phenylimidazo[1,2-a]pyridine-3-carboxylic Acid Derivatives: Synthesis and Antiinflammatory Activity
Anna Di Chiacchio
1
,
Maria Grazia Rimoli
1
,
Francesca Arena
1
,
Enrico Abignente
1
,
WALTER FILIPPELLI
2
,
Amelia Filippelli
2
,
Guiseppe Falcone
2
Publication type: Journal Article
Publication date: 1998-09-01
Journal:
Archiv der Pharmazie
scimago Q2
wos Q1
SJR: 0.642
CiteScore: 7.9
Impact factor: 4.3
ISSN: 03656233, 15214184
Drug Discovery
Pharmaceutical Science
Abstract
A series of 2-phenylimidazo[1,2-a]pyridine-3-carboxylic esters, acids, and amides were synthesized and pharmacologically tested in order to evaluate their antiinflammatory and analgesic activity and their ulcerogenic action on the gastro-intestinal tract. The most active member of this series of compounds was found to be 6-methyl-2-phenylimidazo[1,2-a]pyridine-3-carboxylic acid (5c).
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