Crystallization-Based Separation of Enantiomers

Crystallization has been used widely from bench top to manufacturing scale for the separation and purification of enantiomers. Provided in this chapter are 1) an overview of various crystallization processes used for enantiomer separation and purification, 2) detailed discussions on two main‐stream processes—chiral separation through diastereomeric salts formation and chiral purification by crystallization, as well as 3) a brief review of chiral resolution by preferential crystallization. The two mainstream crystallization processes are reviewed from fundamental concepts to experimental steps taken to develop a robust process. Representative industrial examples of chiral resolution through diastereomeric salt formation are also discussed.