A Photoswitchable Ligand Targeting the β 1 ‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm**
Anna Duran Corbera
1
,
Melissa Faria
2
,
Yuanyuan Ma
3
,
Eva Prats
4
,
Andre Dias
3
,
Juanlo Catena
5
,
Karen L Martinez
3
,
Demetrio Raldúa
2
,
Amadeu Llebaria
1
,
Xavier Rovira
1, 6
Publication type: Journal Article
Publication date: 2022-06-09
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
35608051
General Chemistry
Catalysis
Abstract
New azobenzene-based molecular photoswitches active for the therapeutic β1-adrenoceptor (β1-AR) are presented. The most promising candidate, named pAzo-2, has a potency and β1/β2 selectivity similar to approved beta blockers. Importantly, pAzo-2 is compatible with imaging techniques and its potential as a cardioselective light-controlled drug has been validated by the reversible photomodulation of the cardiac rhythm in living zebrafish larvae.
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Metrics
19
Total citations:
19
Citations from 2024:
12
(63.16%)
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GOST
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Duran Corbera A. et al. A Photoswitchable Ligand Targeting the β 1 ‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm** // Angewandte Chemie - International Edition. 2022. Vol. 61. No. 30.
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Duran Corbera A., Faria M., Ma Y., Prats E., Dias A., Catena J., Martinez K. L., Raldúa D., Llebaria A., Rovira X. A Photoswitchable Ligand Targeting the β 1 ‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm** // Angewandte Chemie - International Edition. 2022. Vol. 61. No. 30.
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RIS
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TY - JOUR
DO - 10.1002/anie.202203449
UR - https://doi.org/10.1002/anie.202203449
TI - A Photoswitchable Ligand Targeting the β 1 ‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm**
T2 - Angewandte Chemie - International Edition
AU - Duran Corbera, Anna
AU - Faria, Melissa
AU - Ma, Yuanyuan
AU - Prats, Eva
AU - Dias, Andre
AU - Catena, Juanlo
AU - Martinez, Karen L
AU - Raldúa, Demetrio
AU - Llebaria, Amadeu
AU - Rovira, Xavier
PY - 2022
DA - 2022/06/09
PB - Wiley
IS - 30
VL - 61
PMID - 35608051
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Duran Corbera,
author = {Anna Duran Corbera and Melissa Faria and Yuanyuan Ma and Eva Prats and Andre Dias and Juanlo Catena and Karen L Martinez and Demetrio Raldúa and Amadeu Llebaria and Xavier Rovira},
title = {A Photoswitchable Ligand Targeting the β 1 ‐Adrenoceptor Enables Light‐Control of the Cardiac Rhythm**},
journal = {Angewandte Chemie - International Edition},
year = {2022},
volume = {61},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/anie.202203449},
number = {30},
doi = {10.1002/anie.202203449}
}