Synthesis, Physicochemical and Anticonvulsant Properties of NewN-4-Arylpiperazin-1-yl Amides of (2-Aza-1,3-dioxospiro[4.4]non-2-yl)- and [4.5]dec-2-yl)-propionic Acid
Publication type: Journal Article
Publication date: 2007-08-01
scimago Q2
wos Q2
SJR: 0.571
CiteScore: 7.0
Impact factor: 3.6
ISSN: 03656233, 15214184
PubMed ID:
17628031
Drug Discovery
Pharmaceutical Science
Abstract
In continuation of the search of new anticonvulsants, a series of N-4-arylpiperazin-1-yl 2-aza-1,3-dioxospiro[4.4]non-2-yl- (5–8) and [4.5]dec-2-yl- (9–15) propionamides, structurally related to the previously described N-4-arylpiperazin-1-yl amides of 2-aza-1,3-dioxospiro[4.5]dec-2-yl-acetic acid, were synthesized. The designed compounds 5–15 were prepared by condensation of the formerly obtained (2-aza-1,3-dioxospiro[4.5]dec-2-yl)- (3) and (2-aza-1,3-dioxo[4.4]non-2-yl)-(4) propionic acids with the appropriately substituted 4-arylpiperazines, in the presence of the N,N-carbonyldiimidazole (CDIM) reagent. All the compounds were tested for their anticonvulsant activity in the maximum electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure threshold tests. Several compounds 7–10, 13 and 14 revealed protection in the MES screening.
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Obniska J. et al. Synthesis, Physicochemical and Anticonvulsant Properties of NewN-4-Arylpiperazin-1-yl Amides of (2-Aza-1,3-dioxospiro[4.4]non-2-yl)- and [4.5]dec-2-yl)-propionic Acid // Archiv der Pharmazie. 2007. Vol. 340. No. 8. pp. 404-408.
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Obniska J., Kamiński K. Z., Hondo L., Zejc A. Synthesis, Physicochemical and Anticonvulsant Properties of NewN-4-Arylpiperazin-1-yl Amides of (2-Aza-1,3-dioxospiro[4.4]non-2-yl)- and [4.5]dec-2-yl)-propionic Acid // Archiv der Pharmazie. 2007. Vol. 340. No. 8. pp. 404-408.
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TY - JOUR
DO - 10.1002/ardp.200700038
UR - https://doi.org/10.1002/ardp.200700038
TI - Synthesis, Physicochemical and Anticonvulsant Properties of NewN-4-Arylpiperazin-1-yl Amides of (2-Aza-1,3-dioxospiro[4.4]non-2-yl)- and [4.5]dec-2-yl)-propionic Acid
T2 - Archiv der Pharmazie
AU - Obniska, Jolanta
AU - Kamiński, Krzysztof Z.
AU - Hondo, Lukasz
AU - Zejc, Alfred
PY - 2007
DA - 2007/08/01
PB - Wiley
SP - 404-408
IS - 8
VL - 340
PMID - 17628031
SN - 0365-6233
SN - 1521-4184
ER -
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@article{2007_Obniska,
author = {Jolanta Obniska and Krzysztof Z. Kamiński and Lukasz Hondo and Alfred Zejc},
title = {Synthesis, Physicochemical and Anticonvulsant Properties of NewN-4-Arylpiperazin-1-yl Amides of (2-Aza-1,3-dioxospiro[4.4]non-2-yl)- and [4.5]dec-2-yl)-propionic Acid},
journal = {Archiv der Pharmazie},
year = {2007},
volume = {340},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/ardp.200700038},
number = {8},
pages = {404--408},
doi = {10.1002/ardp.200700038}
}
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MLA
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Obniska, Jolanta, et al. “Synthesis, Physicochemical and Anticonvulsant Properties of NewN-4-Arylpiperazin-1-yl Amides of (2-Aza-1,3-dioxospiro[4.4]non-2-yl)- and [4.5]dec-2-yl)-propionic Acid.” Archiv der Pharmazie, vol. 340, no. 8, Aug. 2007, pp. 404-408. https://doi.org/10.1002/ardp.200700038.