Archiv der Pharmazie

, volume 357 , issue 3

Nascent pharmacological advancement in adamantane derivatives

Aman Ragshaniya ¹

Vijay Kumar ¹

Ram K. Tittal ²

Kashmiri Lal ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Chemistry Guru Jambheshwar University of Science & Technology Hisar Haryana India |

Department of Chemistry National Institute of Technology Kurukshetra Haryana India |

Publication type: Journal Article

Publication date: 2023-12-21

Wiley

Archiv der Pharmazie

scimago Q2

wos Q2

SJR: 0.571

CiteScore: 7.0

Impact factor: 3.6

ISSN: 03656233, 15214184

DOI: 10.1002/ardp.202300595

Copy DOI

PubMed ID: 38128028

Drug Discovery

Pharmaceutical Science

Abstract

The adamantane moiety has attracted significant attention since its discovery in 1933 due to its remarkable structural, chemical, and medicinal properties. This molecule has a notable impact in the therapeutic field because of its “add‐on” lipophilicity to any pharmacophoric moieties. As in the case of molecular hybridization, in which one pharmacophore is attached to another one(s) with a probability of increasing the biological activity, adding an adamantane unit improves the absorption distribution, metabolism and excretion properties of the resultant hybrid molecule. This review summarizes various reports highlighting the biological activities of adamantane‐based synthetic compounds and their structure–activity relationship study. The information presented in this review may open up possible dimensions for adamantane‐based drug development and discovery in the pharmaceutical industry after proper structural modifications.

Found

1 citation

Arkhipov Sergey

39 publications, 313 citations

h-index: 11

Boreskov Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences

1 citation

Yarovaya Olga

PhD in Chemistry

117 publications, 1 813 citations, 14 reviews

h-index: 23

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

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GOST Copy

Ragshaniya A. et al. Nascent pharmacological advancement in adamantane derivatives // Archiv der Pharmazie. 2023. Vol. 357. No. 3.

GOST all authors (up to 50) Copy

Ragshaniya A., Kumar V., Tittal R. K., Lal K. Nascent pharmacological advancement in adamantane derivatives // Archiv der Pharmazie. 2023. Vol. 357. No. 3.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/ardp.202300595

UR - https://doi.org/10.1002/ardp.202300595

TI - Nascent pharmacological advancement in adamantane derivatives

T2 - Archiv der Pharmazie

AU - Ragshaniya, Aman

AU - Kumar, Vijay

AU - Tittal, Ram K.

AU - Lal, Kashmiri

PY - 2023

DA - 2023/12/21

PB - Wiley

IS - 3

VL - 357

PMID - 38128028

SN - 0365-6233

SN - 1521-4184

ER -

BibTex

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BibTex (up to 50 authors) Copy

@article{2023_Ragshaniya,

author = {Aman Ragshaniya and Vijay Kumar and Ram K. Tittal and Kashmiri Lal},

title = {Nascent pharmacological advancement in adamantane derivatives},

journal = {Archiv der Pharmazie},

year = {2023},

volume = {357},

publisher = {Wiley},

month = {dec},

url = {https://doi.org/10.1002/ardp.202300595},

number = {3},

doi = {10.1002/ardp.202300595}

}

Publisher

Wiley

Journal

Archiv der Pharmazie

scimago Q2

wos Q2

SJR

0.571

CiteScore

7.0

Impact factor

3.6

ISSN

03656233 (Print)

15214184 (Electronic)