Building 1,2,4-Thiadiazole: Ten Years of Progress

Thiadiazoles are among the privileged pharmacological building blocks due to their unique chemical properties for diverse biological and clinical applications. 1,2,4-Thiadiazole derivatives have recently attained a therapeutic and economic importance that they did not possess a few years ago, thus leading to growing interest in this class of heterocycles. Moreover, the importance of such molecules is not restricted to medicinal chemistry; they also perform well as N,S ligands in coordination chemistry or as important intermediates for fine-chemicals synthesis. In this context, this review systematizes the main advances in the synthesis of 1,2,4-thiadiazole-based compounds in the last ten years and discloses some relevant applications of these compounds during that period.