Journal of Natural Products
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
SCImago
Q1
WOS
Q1
Impact factor
3.3
SJR
0.802
CiteScore
9.1
Categories
Analytical Chemistry
Complementary and Alternative Medicine
Organic Chemistry
Pharmaceutical Science
Drug Discovery
Molecular Medicine
Pharmacology
Areas
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Years of issue
1949, 1971, 1973, 1978-2025
journal names
Journal of Natural Products
J NAT PROD
Top-3 citing journals

Journal of Natural Products
(25515 citations)

Phytochemistry
(15390 citations)

Molecules
(14079 citations)
Top-3 organizations

University of Illinois at Chicago
(332 publications)

University of Chinese Academy of Sciences
(278 publications)

Kunming Institute of Botany, Chinese Academy of Sciences
(270 publications)

University of Chinese Academy of Sciences
(71 publications)

Chinese Academy of Medical Sciences & Peking Union Medical College
(47 publications)

Seoul National University
(44 publications)
Most cited in 5 years
Found
Publications found: 12371
Q2

Determination of KGa‐1b and SHCa‐1 Δ′17O and δ18O via Laser Fluorination of Lithium Fluoride Clay Pellets
Gagnon C., Havel R., Chen J., Piccione G., Ibarra D.
ABSTRACTRationaleStable oxygen isotope measurements in silicate clays, such as smectite and kaolinite, provide crucial information for understanding Earth's climate history and environmental changes. Despite a growing interest in the oxygen isotope analysis of silicate clays and clay‐rich sediments, there lacks a consensus on the preparation and standardization of clay mineral samples. To improve the accuracy and interlaboratory comparisons of clay isotope measurements, especially those involving laser fluorination techniques, newly established kaolinite and smectite oxygen isotope standards are much needed.MethodsWe employed conventional nickel bomb fluorination combined with dual‐inlet isotope ratio mass spectrometry to establish precise δ18O and Δ′17O values for leached clay reference materials KGa‐1b and SHCa‐1, a kaolinite and a hectorite/smectite, respectively. We further measured leached KGa‐1b and SHCa‐1 pressed into pellets with a lithium fluoride as a binding agent for the laser fluorination method, allowing us to test the reproducibility between methods and utilize a standard laser chamber drift correction scheme.ResultsThe laser fluorination technique yielded highly precise and reproducible δ18O and Δ′17O measurements for the KGa‐1b and SHCa‐1, aligning with bomb values of δ18O. This confirms the method's reliability and comparability to conventional isotope measurement techniques while also stressing the importance of proper sample preparation and laser chamber drift corrections.ConclusionsThis study demonstrates that laser fluorination is an effective method for accurately measuring the stable oxygen isotope composition of silicate clays or clay‐rich sediments when corrected with known silicate clay standards. These methods offer a valuable methodology for future research and applications that will significantly improve our understanding of past climate and environmental conditions.
Q2

Rapid Proteomic Amelogenin Sex Estimation of Human and Cattle Remains Using Untargeted Evosep‐timsTOF Mass Spectrometry
Blacka C., Dowle A., Lisowski M., Alexander M., Hendy J., Penkman K., Mosely J.
ABSTRACTRationaleSex estimation by analysis of amelogenin peptides in archaeological and fossil material has recently been gaining great traction within the fields of archaeology and palaeontology. Current widely used proteomic amelogenin sex estimation methods are hindered by relatively long mass spectrometric run times, or targeting peptides specific to human amelogenin proteins. Untargeted, high‐throughput amelogenin sexing would be invaluable for a range of applications, from sex estimation of remains at mass grave sites to broadening the application of rapid amelogenin sexing to non‐hominin species for husbandry and evolutionary studies.MethodsA new acid etch protocol followed by Evosep‐LC‐TIMS‐TOF mass spectrometry is presented for amelogenin analysis, providing global peptide data through rapid mass spectrometric methods in under 20 min per sample (including sample preparation, mass spectrometric acquisition and data processing). This sampling protocol was developed on modern cattle (Bos taurus) teeth, before Evosep‐timsTOF partial validation with archaeological cattle and human (Homo sapiens) teeth, demonstrating the potential of straightforward application of this rapid amelogenin sexing method to a range of taxa.ResultsThe rapid Evosep‐LC‐TIMS‐TOF mass spectrometry methods gave comparable peptide counts to conventional long untargeted methods, while maintaining similar (or faster) acquisition times to those reported in methods targeting specific human amelogenin peptides. Implementation of the novel acid etch sampling approach also streamlined sample preparation without compromising peptide counts.ConclusionsRapid, untargeted Evosep‐LC‐TIMS‐TOF mass spectrometry was successfully implemented in sex estimation of modern and archaeological material from Bos taurus and Homo sapiens teeth. This demonstrates an advancement in low‐cost, high‐throughput amelogenin sex estimation, for both human and zooarchaeological applications.
Q2

Determination of K Isotope Compositions in Sedimentary Rocks and Their Implications for Discriminating Sediment Origin
Cui M., Moynier F., Su B., Hu Y.
ABSTRACTThe advent of a new generation of collision‐cell multicollector inductively‐coupled‐plasma mass‐spectrometers (CC–MC–ICP–MS), the Nu sapphire, has provided a new venue in achieving higher precision K isotopic compositions compared to the older generation of instruments. Here, we take advantage of this new technology to report the K isotopic compositions of eight sediment reference materials. The K isotopic compositions (reported as the δ41K representing the 41K/39K ratios) for these sediment reference materials span a range of 0.2‰: −0.42 ± 0.04‰ (BCSS‐1), −0.51 ± 0.07‰ (MESS‐1), and −0.43 ± 0.01‰ (MESS‐4) for three marine sediments, −0.35 ± 0.07‰ (NIST‐SRM 1646a) for estuarine sediment, −0.40 ± 0.06‰ (NIST‐SRM 2704) and −0.40 ± 0.05‰ (SWR‐3) for two river sediments, −0.55 ± 0.04‰ (NIST‐SRM 1d) for limestone, and −0.46 ± 0.00‰ (SBC‐1) for marine shale. The high‐precision K isotopic data presented herein provide a valuable reference for future quality control and interlaboratory comparisons. Data compilation reveals that biogenic sediments show extremely low K concentrations (K2O = 0.001–0.048 wt.%) and large K isotopic variations (δ41K = −1.88–0.94‰) with an average value of −0.001‰, whereas the abiogenic sediments are featured with light K isotopes (average δ41K value of −0.47‰) and high K concentrations (K2O = 0.52 ~ 4.29 wt.%). This finding suggests that the variation of K isotopes may serve as a useful tool for discriminating the various geneses of sediments.
Q2

Carbon and Nitrogen Isotopic Composition of Duplicate Diet of the Japanese
Yoshinaga J.
ABSTRACTRationaleCarbon and nitrogen stable isotope ratios (δ13C and δ15N) of whole diet have rarely been measured to date though the isotope ratios in human sample have been extensively used for diet and nutritional researches. In order to fully validate the isotope dietary analysis, isotopic information of whole diet is required.Methodsδ13C and δ15N of 150 duplicate diet samples collected in Japan during 2016–2017 were measured. Sixty‐five males and 85 females (mean age: 45 years) donated duplicate diet sample of which δ13C and δ15N were measured by element analyzer‐isotope ratio mass spectrometry.ResultsMean δ13C and δ15N of the 150 duplicate diets were −24.3 (1.1) ‰ and 3.58 (0.93) ‰, respectively, with no gender‐ and age‐dependent variation. δ15N of diet containing seafood (median: 3.60‰, n = 111) was significantly more elevated than that not containing seafood (3.01‰, n = 39). δ15N of Japanese diet is decreasing from 1990s to the present, which is consistent with the national statistics showing decreasing trend of seafood consumption of the Japanese. Contradictory to these observation, dietary δ15N was not elevated in diet samples from the elderlies though the diet of elderlies contained seafood more frequently than those of younger study participants.ConclusionThere were some uncertainties as to whether seafood is a major determinant of dietary δ15N of the Japanese. To further characterize dietary components that determine δ values, isotope ratio analysis of diet of known quantitative dietary components is warranted.
Q2

Combination of Metabolite Analysis and Network Pharmacology to Explore the Potential Anticough Mechanism of Protopine—A Marker in Zhi‐Ke‐Bao Tablets
Zou Q., Chen D., Liu C., Chen Z., Yang X., Xu R., Zhou Z., Chen J., Shi W., Zhang F.
ABSTRACTRationaleProtopine, an active alkaloid in Papaver somniferum L., was abundant in a well‐known anticough traditional Chinese medicine preparation—Zhi‐Ke‐Bao tablets. Till now, the metabolism feature and anticough mechanism of protopine have not been fully elucidated, restricting its further development.MethodsThe metabolites of protopine in rats were profiled by using ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry, and its anticough targets and mechanism were predicted by network pharmacology.ResultsIn rats, a total of 19 metabolites were identified following ingestion of protopine (21 mg/kg/day, i.g.), including 4 in plasma, 6 in urine, 5 in feces, 10 in liver, 2 in spleen, 4 in lung, 3 in kidney, 3 in heart, and 3 in brain. The main metabolic features were ring‐opening, methylation, demethylation, glucuronidation, sulfation, and hydroxylation. Among them, methylation, sulfation, and hydroxylation of protopine in vivo were revealed for the first time. The network pharmacology results show that protopine and its metabolites regulate physiological activities by acting on STAT3, SRC, CASP3, MTOR, MMP9, ESR1, and other targets, involving PI3K‐Akt signaling pathway, FoxO signaling pathway, and TNF signaling pathway, etc.ConclusionsThe metabolic features of protopine and its potential mechanisms for anticough effects were outlined, providing data for further anticough pharmacological validation of protopine.
Q2

Fast Pyrolysis of Cigarette and Cigar Leaves: Differential Analysis of Their Heavy Products by Ultrahigh‐Resolution Mass Spectrometry
Zhu Z., Zhang C., Shi Y., Zou P., Ding N., Zong K., Jia L., Guo D.
ABSTRACTRationaleThe cigars have characteristic flavors in smoke when compared with cigarettes, and cigars from various origins also have a difference in taste. However, little information can be found about the difference in chemical components of smokes between cigar and cigarette as well as between cigars, so it is interesting to compare their pyrolysis product distribution.MethodsThe cigarette and cigar leaves were pyrolyzed in a microfluidized‐bed reactor, and the pyrolysis vapors were condensed and collected using cold traps. Mass spectrometric analysis of condensed liquids was performed utilizing electrospray ionization‐orbitrap mass spectrometry in both positive and negative ion modes.ResultsThe mass spectra of condensable pyrolysis products of three tobacco leaves were obtained by Orbitrap‐MS in both positive and negative ESI modes. The DBE values (to carbon atom number) and the relative distribution (to nitrogen or oxygen atom number) of different products were carefully compared and discussed.ConclusionThe main difference in pyrolysis products between cigarette and cigar leaves relates to N1–N2 class compounds in high‐mass range as well as highly unsaturated nitrogenated compounds, while the one between two cigar leaves is associated with CxHyOzN5–9 and C30‐50HyOzNw compounds. Besides, the oxygenated products that fall into the H/C > 2 and O/C < 1 ranges are also characteristic for Dominican cigar.
Q2

Pioneering Mass Spectrometry: A Tribute to My Mentor Jean‐François Muller and His Enduring Legacy
Frache G.
ABSTRACTProfessor Jean‐François Muller, a distinguished figure in the field of mass spectrometry, made significant contributions to the advancement of analytical chemistry and its applications. As the founding director of the Laboratory of Mass Spectrometry and Laser Chemistry at the University of Metz, Muller played a pivotal role in establishing Metz as a leading center for mass spectrometry research. His pioneering work, particularly in the development of matrix‐assisted laser desorption/ionization (MALDI) instrumentation and Fourier transform ion cyclotron resonance mass Spectrometry (FTICR MS), has had a profound impact on various scientific disciplines. This article commemorates Professor Muller's illustrious career and highlights his collaborative efforts with industrial partners such as Total, which led to groundbreaking advancements in MS analysis. I will delve into the key findings of my thesis which focused on instrumental developments for MALDI analysis and imaging, as well as personal reminiscences and the impact of his inspiring mentorship.
Q2

Systematic Analysis of the Chemical Components of Gentiana urnula Harry Sm Using SIRIUS and Liquid Chromatography High‐Resolution Mass Spectrometry
Yan Z., Ning J., Luo Z., Li D., Wang H., Xie X.
ABSTRACTRationaleGentiana urnula Harry Sm is a frequently utilized traditional Chinese medicine (TCM) with applications in the treatment of a range of ailments including jaundice, gastrointestinal ulcers, and influenza. Despite its widespread uses, there is a lack of comprehensive researches on the chemical composition.MethodsThis study integrated SIRIUS, quantitative structure‐retention relationship (QSRR), and liquid chromatography high‐resolution mass spectrometry (LC‐HRMS) to identify the compounds in Gentiana urnula Harry Sm.ResultsA total of 213 compounds were identified with high confidence based on retention time (tR), MS1, and MS/MS. Among the 213 compounds, 26 compounds were positively identified firstly in Gentiana urnula Harry Sm. More than 5000 compounds were classified based on MS/MS. Spatial distribution revealed the similarities in compound between roots and stems, while differences were observed between leaves and flowers.ConclusionsThis study lays the foundation for further investigations into the biological activity and pharmacological mechanism of Gentiana urnula Harry Sm.
Q2

Part B: SLICE‐MSI—A Machine Learning Interface for System Suitability Testing of Mass Spectrometry Imaging Platforms
Kibbe R., Mills Q., Sohn A., Muddiman D.
ABSTRACTRationaleThe field of mass spectrometry imaging is currently devoid of standardized protocols or commercially available products designed for system suitability testing of MSI platforms. Machine learning is an approach that can quickly and effectively identify complex patterns in data and use them to make informed classifications, but there is a technical barrier to implementing these algorithms. Here we package the machine learning algorithms into a user‐friendly interface to make community‐wide implementation of this protocol possible.MethodsThe software package is built entirely in the Python language using the PySimpleGUI library for the construction of the interface, Pandas and Numpy libraries for data formatting and manipulation, and the Scikit‐Learn library for the implementation of machine learning algorithms. Training data is collected on an instrument under clean and compromised conditions that can then be used to evaluate model performance and to train models prior to interrogating unknown samples before, during, or after experiments.ResultsDetailed instructions are provided for the effective use of the SLICE‐MSI software package to use machine learning to evaluate instrument condition of MSI platforms. File formatting and generalizable steps are clearly described to make the implementation of this package easy for multiple labs and different MSI platform configurations.ConclusionsIn this protocol, we demonstrate SLICE‐MSI, a machine learning graphical user interface for efficient and easy implementation of QC instrument classification of mass spectrometry imaging platforms.
Q2

Part A: Implementing an Analyte Panel and Sampling Protocol for Quality Control in Mass Spectrometry Imaging
Mills Q., Kibbe R., Sohn A., Percy A., Backiel K., Muddiman D.
ABSTRACTRationaleWhile quality control (QC) and system suitability testing (SST) methods are commonly employed in mass spectrometry, the field of mass spectrometry imaging (MSI) currently lacks any universally accepted QC/SST protocols. These methods can prevent the loss of precious samples due to suboptimal instrument conditions and/or data quality, but they are more challenging to implement on MSI platforms. Herein, a panel of analytes is conveniently analyzed in a setup that reflects a typical MSI imaging experiment, and guidance is provided for downstream QC/SST evaluation.MethodsThe analyte panel will be commercially available and consists of three pairs of unlabeled (NAT) analytes and their stable isotope–labeled (SIL) analogues; a deviation from the standard procedure is also included, which incorporates a polymer to expand m/z coverage. The NAT three‐plex (or four‐plex with the added polymer) is analyzed as a droplet on a slide, and the SIL three‐plex is doped into the electrospray solvent, isolating the NAT and SIL compounds to different source components. Datasets are collected on clean and compromised instruments to inform QC/SST software and later evaluate instrument conditions or isolated metrics of data quality.ResultsA procedure was created for QC/SST analysis on MSI platforms, which can be optionally paired with the freely available software Supervised Learning for Instrument Classification and Evaluation for Mass Spectrometry Imaging (SLICE‐MSI) to classify the condition of the instrument. The SIL data may be monitored separately during imaging experiments for continuous evaluation of electrospray stability. The protocol highlights areas that may be adapted for other ionization sources for widespread use.ConclusionsThe protocol described herein uses a panel of NAT and SIL compounds to offer an objective and accurate determination of QC/SST on MSI platforms.
Q2

Determination of Collisional Cross Section Using Microscale High‐Field Asymmetric Waveform ion Mobility Spectroscopy–Mass Spectrometry (FAIMS‐MS)
Krasnova K., Creaser C., Reynolds J.
ABSTRACTRationaleCollisional cross sections (CCS) are an important characteristic of gas‐phase ions that are measured using ion mobility‐mass spectrometry (IMS). Typically, CCS measurements are performed with drift‐tube IMS or travelling‐wave IMS. However. in a high‐field asymmetric waveform ion mobility (FAIMS) device, ion heating effects make CCS determination more challenging. This research explores whether CCS can be predicted with microscale FAIMS by using known CCS standards.MethodsAn Owlstone ultraFAIMS microscale FAIMS spectrometer was coupled to an Orbitrap Exactive mass spectrometer. Two different CCS standard mixtures (tetraalkylammonium halides [TAAHs] and poly‐DL‐alanine oligomers) were used to evaluate the system's potential to determine CCS. Test peptide bradykinin acetate and substance P were used to evaluate CCS determination accuracy for singly and doubly charged peptide species using external calibration with a series of poly‐DL‐alanine peptides for +1, +2 charge states.ResultsCalibrations with excellent correlation coefficients (R2 = 0.99) for both TAAHs and poly‐DL‐alanine were obtained. Good accuracy of determination was achieved for bradykinin [M + 2H]2+ with a ± 0.5% difference between experimental and published CCS at a dispersion field (DF) strength of 250 Td; the model proved less accurate for bradykinin [M + H]+ (±1.4% at 240 Td). The accuracy of determination for the [M + H]+ and [M + 2H]2+ ions of substance P was within ± 5% and ± 3% at 250 Td, respectively, while at higher DF values, accuracy decreased to approximately 5%.ConclusionsDistinct relationships were observed between CCS and transmission CF with both calibrants. Optimum accuracy was obtained at DF 240–260 Td. At lower DF, accuracy is reduced by insufficient resolution of analyte ions from solvent cluster adducts, while at higher DF values, poor transmission becomes a factor. Nevertheless, these data suggest microscale FAIMS can conduct CCS measurements with reasonable accuracy when the compound being measured has similar structural features to the CCS standards used.
Q2

Improved Protective Effects and Pharmacokinetics of Huperzine A Derivative H14 in Soman Poisoning: A Comparative Study With Huperzine A in Rats
Yang G., Cui Y., Zong X., Jin Q., Zhang Y., Li L., Liu D., Chen X., Wang C., Wei J.
ABSTRACTRationaleN‐[2‐Hydroxy‐3,5‐dimethylbenzilidene]‐Hup A (H14) is a derivative of huperzine A (Hup A) that demonstrates superior protective effects against soman (GD) compared to Hup A. This study aims to evaluate the protective efficacy of H14 pretreatment against GD in rats and to provide an analytical framework for the pharmacokinetic evaluation of H14 in experimental animals.MethodsThe study employed protective ratios (PR) as an evaluation criterion to assess the efficacy of H14 and Hup A in preventing GD in vivo. Liquid–liquid extraction techniques were utilized to extract H14 and its metabolite, Hup A, from plasma. The extracted plasma samples were then analyzed using an ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method for the simultaneous quantification of H14 and Hup A.ResultsThe PR values for the 6‐ and 12‐h Hup A groups were 1.26 and 1.08, respectively. In contrast, the 6, 12, and 24‐h H14 groups demonstrated PR values of 2.81, 1.98, and 1.18, respectively, indicating extended protective capabilities compared to Hup A. All validation parameters for the UHPLC–MS/MS method, including linearity, specificity, precision, accuracy, matrix effect, and stability, met the acceptance criteria established by FDA guidelines. The pharmacokinetic analysis indicates that H14, after conversion to Hup A in vivo, significantly extends the duration of Hup A concentrations in the body, leading to more effective prevention of GD poisoning compared to Hup A alone.ConclusionsH14 demonstrates superior efficacy in preventing GD poisoning compared to Hup A. Furthermore, this analytical approach offers a reliable and efficient method for the pharmacokinetic evaluation of H14 in experimental animals.
Q2

Covalent Organic Framework Nanofilm‐Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products
Yan L., Zheng W., Lin Z.
ABSTRACTRationalBenzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine‐disrupting effects. Sensitive and efficient analytical methods are in demand for their detection. In this study, we developed a TAPB‐DMTP‐covalent organic framework (COF) nanofilm‐assisted laser desorption ionization mass spectrometry (LDI‐MS) method for the quantitative analysis of 2,4‐dihydroxybenzophenone (BP‐1) in PCPs.MethodsThe TAPB‐DMTP‐COF nanofilm was synthesized on indium tin oxide (ITO) glass and utilized as an LDI‐MS substrate. The performance of TAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS for analyzing small molecules (e.g., benzophenone derivatives, phthalates, amino acids, sugars, and nucleosides) was compared to conventional organic matrices (α‐cyano‐4‐hydroxycinnamic acid [CHCA], 2,5‐dihydroxybenzoic acid [DHB], and sinapinic acid [SA]). The reproducibility, salt resistance, sensitivity, and stability of the method were further evaluated. Finally, the technique was applied to quantify BP‐1 in PCPs.ResultsThe TAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS provided stronger mass spectral signals and cleaner backgrounds for small molecules compared to CHCA, DHB, and SA. The method exhibited high reproducibility (RSD = 6.10%) and stability for up to 30 days. BP‐1 in PCPs was quantified with excellent linearity (1–20 μg/mL, r = 0.9993), a low detection limit (0.3 μg/mL), and recovery rates of 94.2%–104.4%, demonstrating the potential of TAPB‐DMTP‐COF nanofilm for sensitive and reliable small‐molecule analysis.ConclusionTAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS offered the advantages of rapid analysis, clean backgrounds, and reproducibility for detecting small molecules, including benzophenone derivatives. This method successfully quantified BP‐1 in PCPs, highlighting its suitability for analyzing complex samples.
Q2

Assessing Matrix and Nonmatrix, Single, and Multipoint Calibration of Trace Elements Using LA‐ICP‐MS on a Tropical Speleothem
Sekhon N., Gao A., Mallick S., Partin J., Cardenas M. ., Ibarra D.
ABSTRACTRationaleSuites of trace elements are routinely used in speleothems as proxies to understand periods of past climate change. Laser ablation techniques are regularly implemented to acquire high resolution (50‐μm) trace element concentrations in carbonate archives for paleoclimatology. There exists limited research investigating Laser Ablation‐Inductively Coupled Plasma‐Mass Spectrometry (LA‐ICP‐MS) protocols using speleothem samples. This study investigates the difference between using matrix (carbonate) and nonmatrix (silicate) matched reference materials and the utility of 1‐point versus multiple point calibration curves.MethodsFollowing an extensive review of published literature on speleothem LA‐ICP‐MS analyses, we conducted two laser ablation experimental runs 8 months apart on a 2.7‐cm section of a natural speleothem using matrix and nonmatrix matched reference materials. We used a 193‐nm wavelength Analyte G2 laser attached to a X‐Series‐2 ICP‐MS, a silicate reference material, and three carbonate reference materials. Next, we calculated concentrations using a 1‐point calibration curve, a 2‐point calibration curve, and a 3‐point calibration curve.ResultsThe analysis of matrix and nonmatrix matched reference materials demonstrates that the trends of trace elements/Ca are minimally impacted by the matrix material of the standard. We also show that 2‐ and 3‐point calibration curves bracket the range of sample concentrations compared to a 1‐point (silicate) calibration curve. The calculated cave‐air temperatures using Mg/Ca concentrations fall within error of each other regardless of the calibration curve approach applied.ConclusionsOur experiments provide a proof of concept on the conventional setup of standards during LA‐ICP‐MS speleothem analysis. We suggest the use of at minimum a 2‐point (silicate plus carbonate or carbonates) calibration curve that crucially bracket the range of sample concentrations rather than relying on a 1‐point silicate standard that does not bracket the sample concentration. Finally, our results have implications for both speleothem studies that use LA‐ICP‐MS analytical techniques and additional carbonate archives.
Q2

Exploration of Active Substances and Its Potential Mechanism of Gancao Fuzi Decoction on Inflammatory Based on Metabolomics and Network Pharmacology
Geng W., Liu S., Dong H., Arachchige B., Qi D., Wang X.
ABSTRACTGancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT in the treatment of inflammation is not fully clarified. In this study, we used orthogonal experiments to design different GCFZT formulations, resulting in a total of 16 GCFZT formulations. Subsequently, UPLC‐Q‐TOF‐MS/MS was used to analyze the chemical composition of different formulations, and the anti‐inflammatory activity differences of these formulations were evaluated through an LPS‐induced RAW264.7 inflammatory cell model. Combined with machine learning algorithms such as PLS‐DA and RF, four main active substances in GCFZT were screened. Finally, network pharmacology techniques were used to investigate the potential anti‐inflammatory mechanisms of these main active substances, and the results showed that GCFZT mainly regulates the expression of core targets such as ALOX5, NFKB1, and TLR4 through main active substances such as chlorogenic acid, riboflavin, and formononetin, thereby affecting the NF kappa B signaling pathway, the Toll‐like receptor signaling pathway, and the Th17 cell differentiation. This study provides a reference for the anti‐inflammatory mechanism of GCFZT and a scientific basis for its clinical application.
Top-100
Citing journals
5000
10000
15000
20000
25000
30000
|
|
Journal of Natural Products
25515 citations, 5.03%
|
|
Phytochemistry
15390 citations, 3.03%
|
|
Molecules
14079 citations, 2.78%
|
|
Marine Drugs
12648 citations, 2.49%
|
|
Natural Product Reports
12133 citations, 2.39%
|
|
Tetrahedron
9089 citations, 1.79%
|
|
Tetrahedron Letters
8152 citations, 1.61%
|
|
Natural Product Research
7966 citations, 1.57%
|
|
Organic Letters
7951 citations, 1.57%
|
|
Fitoterapia
7691 citations, 1.52%
|
|
Journal of Organic Chemistry
6835 citations, 1.35%
|
|
Journal of Ethnopharmacology
6213 citations, 1.22%
|
|
Chemistry and Biodiversity
5305 citations, 1.05%
|
|
Natural Product Communications
5281 citations, 1.04%
|
|
Phytochemistry Letters
4809 citations, 0.95%
|
|
Organic and Biomolecular Chemistry
4375 citations, 0.86%
|
|
Bioorganic and Medicinal Chemistry Letters
4110 citations, 0.81%
|
|
RSC Advances
4092 citations, 0.81%
|
|
Journal of Agricultural and Food Chemistry
4011 citations, 0.79%
|
|
Studies in Natural Products Chemistry
3960 citations, 0.78%
|
|
Planta Medica
3943 citations, 0.78%
|
|
Biochemical Systematics and Ecology
3847 citations, 0.76%
|
|
Journal of Asian Natural Products Research
3435 citations, 0.68%
|
|
Bioorganic Chemistry
3417 citations, 0.67%
|
|
European Journal of Medicinal Chemistry
3378 citations, 0.67%
|
|
Chemistry of Natural Compounds
3376 citations, 0.67%
|
|
Bioorganic and Medicinal Chemistry
3348 citations, 0.66%
|
|
Chemical and Pharmaceutical Bulletin
3298 citations, 0.65%
|
|
European Journal of Organic Chemistry
3284 citations, 0.65%
|
|
International Journal of Molecular Sciences
3046 citations, 0.6%
|
|
Angewandte Chemie
2811 citations, 0.55%
|
|
Angewandte Chemie - International Edition
2695 citations, 0.53%
|
|
Phytochemistry Reviews
2692 citations, 0.53%
|
|
Helvetica Chimica Acta
2442 citations, 0.48%
|
|
Journal of the American Chemical Society
2226 citations, 0.44%
|
|
Frontiers in Pharmacology
2066 citations, 0.41%
|
|
Scientific Reports
1954 citations, 0.39%
|
|
Chemistry - A European Journal
1912 citations, 0.38%
|
|
Phytotherapy Research
1885 citations, 0.37%
|
|
Journal of Antibiotics
1777 citations, 0.35%
|
|
Frontiers in Microbiology
1771 citations, 0.35%
|
|
Chemical Reviews
1698 citations, 0.33%
|
|
Food Chemistry
1666 citations, 0.33%
|
|
Phytomedicine
1595 citations, 0.31%
|
|
Plants
1593 citations, 0.31%
|
|
Archives of Pharmacal Research
1568 citations, 0.31%
|
|
Journal of Medicinal Chemistry
1530 citations, 0.3%
|
|
PLoS ONE
1499 citations, 0.3%
|
|
Heterocycles
1464 citations, 0.29%
|
|
Chemical Communications
1461 citations, 0.29%
|
|
Journal of Natural Medicines
1430 citations, 0.28%
|
|
Alkaloids: Chemistry and Biology
1426 citations, 0.28%
|
|
Chinese Journal of Natural Medicines
1400 citations, 0.28%
|
|
Organic Chemistry Frontiers
1356 citations, 0.27%
|
|
Journal of Chromatography A
1261 citations, 0.25%
|
|
Natural Products and Bioprospecting
1249 citations, 0.25%
|
|
Magnetic Resonance in Chemistry
1220 citations, 0.24%
|
|
Pharmaceutical Biology
1203 citations, 0.24%
|
|
Industrial Crops and Products
1178 citations, 0.23%
|
|
Advanced Synthesis and Catalysis
1167 citations, 0.23%
|
|
Progress in the chemistry of organic natural products
1131 citations, 0.22%
|
|
Applied Microbiology and Biotechnology
1128 citations, 0.22%
|
|
Synthesis
1072 citations, 0.21%
|
|
ChemistrySelect
1030 citations, 0.2%
|
|
Evidence-based Complementary and Alternative Medicine
1011 citations, 0.2%
|
|
South African Journal of Botany
988 citations, 0.19%
|
|
Journal of Molecular Structure
980 citations, 0.19%
|
|
Biomedicine and Pharmacotherapy
980 citations, 0.19%
|
|
Phytochemical Analysis
956 citations, 0.19%
|
|
Journal of Pharmaceutical and Biomedical Analysis
955 citations, 0.19%
|
|
ACS Omega
932 citations, 0.18%
|
|
Steroids
905 citations, 0.18%
|
|
Chinese Chemical Letters
901 citations, 0.18%
|
|
Pharmaceuticals
868 citations, 0.17%
|
|
Synlett
843 citations, 0.17%
|
|
Journal of Fungi
839 citations, 0.17%
|
|
Medicinal Chemistry Research
825 citations, 0.16%
|
|
Biomolecules
811 citations, 0.16%
|
|
Frontiers in Chemistry
783 citations, 0.15%
|
|
ChemBioChem
777 citations, 0.15%
|
|
Tetrahedron Asymmetry
769 citations, 0.15%
|
|
Beilstein Journal of Organic Chemistry
757 citations, 0.15%
|
|
Chinese Journal of Chemistry
745 citations, 0.15%
|
|
Antioxidants
740 citations, 0.15%
|
|
The Alkaloids: Chemistry and Pharmacology
737 citations, 0.15%
|
|
Antibiotics
732 citations, 0.14%
|
|
Toxins
702 citations, 0.14%
|
|
Food and Chemical Toxicology
700 citations, 0.14%
|
|
Biological and Pharmaceutical Bulletin
692 citations, 0.14%
|
|
Journal of Heterocyclic Chemistry
631 citations, 0.12%
|
|
International Journal of Biological Macromolecules
625 citations, 0.12%
|
|
Asian Journal of Organic Chemistry
622 citations, 0.12%
|
|
Journal of Essential Oil Research
609 citations, 0.12%
|
|
Biotechnology Advances
595 citations, 0.12%
|
|
Bulletin of the Korean Chemical Society
590 citations, 0.12%
|
|
Synthetic Communications
587 citations, 0.12%
|
|
Toxicon
578 citations, 0.11%
|
|
Microorganisms
571 citations, 0.11%
|
|
Carbohydrate Research
569 citations, 0.11%
|
|
Revista Brasileira de Farmacognosia
563 citations, 0.11%
|
|
Show all (70 more) | |
5000
10000
15000
20000
25000
30000
|
Citing publishers
20000
40000
60000
80000
100000
120000
140000
160000
|
|
Elsevier
141706 citations, 27.94%
|
|
American Chemical Society (ACS)
58635 citations, 11.56%
|
|
Wiley
55500 citations, 10.94%
|
|
Springer Nature
48524 citations, 9.57%
|
|
MDPI
45298 citations, 8.93%
|
|
Royal Society of Chemistry (RSC)
30095 citations, 5.93%
|
|
Taylor & Francis
26329 citations, 5.19%
|
|
Georg Thieme Verlag KG
7623 citations, 1.5%
|
|
Frontiers Media S.A.
7453 citations, 1.47%
|
|
SAGE
6852 citations, 1.35%
|
|
Pharmaceutical Society of Japan
4419 citations, 0.87%
|
|
Bentham Science Publishers Ltd.
4254 citations, 0.84%
|
|
Hindawi Limited
3416 citations, 0.67%
|
|
Oxford University Press
2041 citations, 0.4%
|
|
Public Library of Science (PLoS)
1864 citations, 0.37%
|
|
The Japan Institute of Heterocyclic Chemistry
1758 citations, 0.35%
|
|
Pharmaceutical Society of Korea
1648 citations, 0.32%
|
|
American Society for Microbiology
1451 citations, 0.29%
|
|
Walter de Gruyter
1390 citations, 0.27%
|
|
Pleiades Publishing
1269 citations, 0.25%
|
|
Cold Spring Harbor Laboratory
1230 citations, 0.24%
|
|
King Saud University
1136 citations, 0.22%
|
|
Ovid Technologies (Wolters Kluwer Health)
875 citations, 0.17%
|
|
862 citations, 0.17%
|
|
Beilstein-Institut
819 citations, 0.16%
|
|
Mary Ann Liebert
772 citations, 0.15%
|
|
Spandidos Publications
769 citations, 0.15%
|
|
Cambridge University Press
698 citations, 0.14%
|
|
Science Alert
698 citations, 0.14%
|
|
International Union of Crystallography (IUCr)
619 citations, 0.12%
|
|
American Society for Biochemistry and Molecular Biology
604 citations, 0.12%
|
|
Proceedings of the National Academy of Sciences (PNAS)
559 citations, 0.11%
|
|
SciELO
492 citations, 0.1%
|
|
IntechOpen
488 citations, 0.1%
|
|
Canadian Science Publishing
439 citations, 0.09%
|
|
The Chemical Society of Japan
431 citations, 0.08%
|
|
IOP Publishing
412 citations, 0.08%
|
|
World Scientific
376 citations, 0.07%
|
|
CSIRO Publishing
368 citations, 0.07%
|
|
Scientific Research Publishing
323 citations, 0.06%
|
|
American Society for Pharmacology and Experimental Therapeutics
315 citations, 0.06%
|
|
Impact Journals
267 citations, 0.05%
|
|
Academic Journals
265 citations, 0.05%
|
|
American Association for Cancer Research (AACR)
262 citations, 0.05%
|
|
Microbiology Society
251 citations, 0.05%
|
|
IGI Global
243 citations, 0.05%
|
|
AIP Publishing
232 citations, 0.05%
|
|
Shanghai Institute of Organic Chemistry
224 citations, 0.04%
|
|
The Society of Synthetic Organic Chemistry, Japan
207 citations, 0.04%
|
|
PeerJ
201 citations, 0.04%
|
|
Korean Society of Food Science and Nutrition
195 citations, 0.04%
|
|
188 citations, 0.04%
|
|
Akademiai Kiado
187 citations, 0.04%
|
|
American Association for the Advancement of Science (AAAS)
186 citations, 0.04%
|
|
Scientific Societies
183 citations, 0.04%
|
|
S. Karger AG
175 citations, 0.03%
|
|
Asian Network for Scientific Information
172 citations, 0.03%
|
|
Annual Reviews
163 citations, 0.03%
|
|
Trans Tech Publications
161 citations, 0.03%
|
|
Academia Brasileira de Ciencias
159 citations, 0.03%
|
|
Korean Society of Food Science and Technology
151 citations, 0.03%
|
|
A and V Publications
146 citations, 0.03%
|
|
Medknow
144 citations, 0.03%
|
|
Korean Society of Pharmacognosy
131 citations, 0.03%
|
|
Research Square Platform LLC
129 citations, 0.03%
|
|
American Society for Nutrition
125 citations, 0.02%
|
|
122 citations, 0.02%
|
|
Westerdijk Fungal Biodiversity Institute
110 citations, 0.02%
|
|
Pensoft Publishers
109 citations, 0.02%
|
|
EDP Sciences
107 citations, 0.02%
|
|
Korean Society of Applied Pharmacology
107 citations, 0.02%
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
106 citations, 0.02%
|
|
Oriental Scientific Publishing Company
105 citations, 0.02%
|
|
103 citations, 0.02%
|
|
Institute of Electrical and Electronics Engineers (IEEE)
102 citations, 0.02%
|
|
The Royal Society
100 citations, 0.02%
|
|
Asian Journal of Chemistry
99 citations, 0.02%
|
|
The Korean Society for Applied Biological Chemistry
94 citations, 0.02%
|
|
Tsinghua University Press
93 citations, 0.02%
|
|
Korean Society for Biotechnology and Bioengineering
93 citations, 0.02%
|
|
Korean Society of Mycology
91 citations, 0.02%
|
|
Hans Publishers
90 citations, 0.02%
|
|
Portland Press
89 citations, 0.02%
|
|
F1000 Research
89 citations, 0.02%
|
|
Asian Pacific Journal of Tropical Medicine Press
86 citations, 0.02%
|
|
Instituto de Tecnologia do Parana
85 citations, 0.02%
|
|
Baishideng Publishing Group
85 citations, 0.02%
|
|
International Society for Nutraceuticals & Functional Foods (ISNFF)
85 citations, 0.02%
|
|
Japan Oil Chemists' Society
82 citations, 0.02%
|
|
81 citations, 0.02%
|
|
Magnolia Press
76 citations, 0.01%
|
|
Asian Pacific Organization for Cancer Prevention
75 citations, 0.01%
|
|
IOS Press
70 citations, 0.01%
|
|
Fundacao Oswaldo Cruz
67 citations, 0.01%
|
|
Han-Gug Misaengmul Hag-hoe/The Microbiological Society of Korea
65 citations, 0.01%
|
|
Japan Society for Analytical Chemistry
64 citations, 0.01%
|
|
Institute of Organic Chemistry & Biochemistry
64 citations, 0.01%
|
|
63 citations, 0.01%
|
|
eLife Sciences Publications
63 citations, 0.01%
|
|
National Library of Serbia
62 citations, 0.01%
|
|
Show all (70 more) | |
20000
40000
60000
80000
100000
120000
140000
160000
|
Publishing organizations
50
100
150
200
250
300
350
|
|
University of Illinois at Chicago
332 publications, 2.05%
|
|
University of Chinese Academy of Sciences
278 publications, 1.72%
|
|
Kunming Institute of Botany, Chinese Academy of Sciences
270 publications, 1.67%
|
|
Chinese Academy of Medical Sciences & Peking Union Medical College
265 publications, 1.64%
|
|
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
201 publications, 1.24%
|
|
Seoul National University
197 publications, 1.22%
|
|
Kaohsiung Medical University
182 publications, 1.13%
|
|
Frederick National Laboratory for Cancer Research
172 publications, 1.06%
|
|
University of California, San Diego
171 publications, 1.06%
|
|
National Taiwan University
149 publications, 0.92%
|
|
National Sun Yat-sen University
142 publications, 0.88%
|
|
University of Naples Federico II
141 publications, 0.87%
|
|
University of North Carolina at Chapel Hill
138 publications, 0.85%
|
|
Scripps Institution of Oceanography
135 publications, 0.84%
|
|
Virginia Tech
134 publications, 0.83%
|
|
National Research Institute of Chinese Medicine
133 publications, 0.82%
|
|
National Autonomous University of Mexico
133 publications, 0.82%
|
|
Arizona State University
129 publications, 0.8%
|
|
Ocean University of China
121 publications, 0.75%
|
|
Griffith University
121 publications, 0.75%
|
|
University of Queensland
106 publications, 0.66%
|
|
University of Tokyo
106 publications, 0.66%
|
|
China Pharmaceutical University
98 publications, 0.61%
|
|
Oregon State University
93 publications, 0.58%
|
|
Helmholtz Centre for Infection Research
91 publications, 0.56%
|
|
Hokkaido University
89 publications, 0.55%
|
|
University of Salerno
86 publications, 0.53%
|
|
Ohio State University
86 publications, 0.53%
|
|
Jinan University
84 publications, 0.52%
|
|
Shenyang Pharmaceutical University
84 publications, 0.52%
|
|
Peking University
82 publications, 0.51%
|
|
Purdue University
81 publications, 0.5%
|
|
Sun Yat-sen University
80 publications, 0.5%
|
|
Huazhong University of Science and Technology
78 publications, 0.48%
|
|
Korea Research Institute of Bioscience and Biotechnology
77 publications, 0.48%
|
|
Chiba University
76 publications, 0.47%
|
|
University of Arizona
71 publications, 0.44%
|
|
Tokyo University of Pharmacy and Life Sciences
71 publications, 0.44%
|
|
Second Military Medical University
69 publications, 0.43%
|
|
Tokushima Bunri University
69 publications, 0.43%
|
|
Heinrich Heine University Düsseldorf
68 publications, 0.42%
|
|
University of Malaya
67 publications, 0.41%
|
|
National Center for Genetic Engineering and Biotechnology
65 publications, 0.4%
|
|
University of Utah
65 publications, 0.4%
|
|
University of California, Santa Cruz
64 publications, 0.4%
|
|
University of La Laguna
64 publications, 0.4%
|
|
Sungkyunkwan University
63 publications, 0.39%
|
|
National Cheng Kung University
62 publications, 0.38%
|
|
Shandong University
62 publications, 0.38%
|
|
Korea Research Institute of Chemical Technology
61 publications, 0.38%
|
|
China Medical University (Taiwan)
59 publications, 0.37%
|
|
Hans Knöll Institute (Leibniz Institute for Natural Product Research and Infection Biology)
59 publications, 0.37%
|
|
Shanghai Jiao Tong University
58 publications, 0.36%
|
|
Chulalongkorn University
57 publications, 0.35%
|
|
University of Basel
56 publications, 0.35%
|
|
Lanzhou University
56 publications, 0.35%
|
|
Université Paris-Saclay
56 publications, 0.35%
|
|
Mahidol University
55 publications, 0.34%
|
|
University of Toyama
55 publications, 0.34%
|
|
University of Copenhagen
54 publications, 0.33%
|
|
University of British Columbia
54 publications, 0.33%
|
|
Rhenish Friedrich Wilhelm University of Bonn
53 publications, 0.33%
|
|
Universidade Estadual Paulista
53 publications, 0.33%
|
|
University of Karachi
52 publications, 0.32%
|
|
Yunnan University
52 publications, 0.32%
|
|
Korea University
51 publications, 0.32%
|
|
National Institute of Diabetes and Digestive and Kidney Diseases
51 publications, 0.32%
|
|
Technical University of Braunschweig
50 publications, 0.31%
|
|
University of Vienna
50 publications, 0.31%
|
|
Tel Aviv University
48 publications, 0.3%
|
|
Uppsala University
47 publications, 0.29%
|
|
Taipei Medical University
47 publications, 0.29%
|
|
University of Amsterdam
47 publications, 0.29%
|
|
Zhejiang University
46 publications, 0.28%
|
|
Institute of Biomolecular Chemistry
46 publications, 0.28%
|
|
Pusan National University
46 publications, 0.28%
|
|
RIKEN-Institute of Physical and Chemical Research
46 publications, 0.28%
|
|
National Cancer Institute
46 publications, 0.28%
|
|
G. B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences
45 publications, 0.28%
|
|
Chungnam National University
45 publications, 0.28%
|
|
Tohoku University
45 publications, 0.28%
|
|
University of North Carolina at Greensboro
45 publications, 0.28%
|
|
Technical University of Denmark
44 publications, 0.27%
|
|
University of Pisa
44 publications, 0.27%
|
|
University of Puerto Rico
44 publications, 0.27%
|
|
Hiroshima University
44 publications, 0.27%
|
|
Kyoto Prefectural University of Medicine
43 publications, 0.27%
|
|
Kyung Hee University
42 publications, 0.26%
|
|
Queensland Museum
42 publications, 0.26%
|
|
Kyoto Pharmaceutical University
41 publications, 0.25%
|
|
University of Florida
41 publications, 0.25%
|
|
University of Cádiz
41 publications, 0.25%
|
|
Swiss Tropical and Public Health Institute
40 publications, 0.25%
|
|
Chang Gung University
40 publications, 0.25%
|
|
Ewha Womans University
40 publications, 0.25%
|
|
University of Wisconsin–Madison
40 publications, 0.25%
|
|
Universidade Estadual de Campinas
40 publications, 0.25%
|
|
University of Geneva
39 publications, 0.24%
|
|
University of Eastern Piedmont Amadeo Avogadro
39 publications, 0.24%
|
|
Chinese University of Hong Kong
39 publications, 0.24%
|
|
Show all (70 more) | |
50
100
150
200
250
300
350
|
Publishing organizations in 5 years
10
20
30
40
50
60
70
80
|
|
University of Chinese Academy of Sciences
71 publications, 4.12%
|
|
Chinese Academy of Medical Sciences & Peking Union Medical College
47 publications, 2.73%
|
|
Seoul National University
44 publications, 2.55%
|
|
Ocean University of China
43 publications, 2.49%
|
|
University of Illinois at Chicago
34 publications, 1.97%
|
|
Huazhong University of Science and Technology
32 publications, 1.86%
|
|
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
31 publications, 1.8%
|
|
China Pharmaceutical University
28 publications, 1.62%
|
|
University of Queensland
27 publications, 1.57%
|
|
Griffith University
27 publications, 1.57%
|
|
Shandong University
27 publications, 1.57%
|
|
Kunming Institute of Botany, Chinese Academy of Sciences
27 publications, 1.57%
|
|
Jinan University
26 publications, 1.51%
|
|
Sun Yat-sen University
25 publications, 1.45%
|
|
Shenyang Pharmaceutical University
25 publications, 1.45%
|
|
University of Naples Federico II
21 publications, 1.22%
|
|
Frederick National Laboratory for Cancer Research
21 publications, 1.22%
|
|
University of California, San Diego
20 publications, 1.16%
|
|
Shanghai Jiao Tong University
18 publications, 1.04%
|
|
Sungkyunkwan University
18 publications, 1.04%
|
|
Yunnan University
18 publications, 1.04%
|
|
Uppsala University
17 publications, 0.99%
|
|
Helmholtz Centre for Infection Research
17 publications, 0.99%
|
|
Scripps Institution of Oceanography
17 publications, 0.99%
|
|
University of Tokyo
17 publications, 0.99%
|
|
Université Paris-Saclay
17 publications, 0.99%
|
|
Keio University
16 publications, 0.93%
|
|
Hans Knöll Institute (Leibniz Institute for Natural Product Research and Infection Biology)
16 publications, 0.93%
|
|
University of North Carolina at Chapel Hill
16 publications, 0.93%
|
|
University of Malaya
14 publications, 0.81%
|
|
Nanjing University of Chinese Medicine
14 publications, 0.81%
|
|
Technical University of Denmark
14 publications, 0.81%
|
|
University of Florida
14 publications, 0.81%
|
|
University of North Carolina at Greensboro
14 publications, 0.81%
|
|
University of Salerno
13 publications, 0.75%
|
|
University of Western Australia
13 publications, 0.75%
|
|
Korea University
13 publications, 0.75%
|
|
Technical University of Braunschweig
13 publications, 0.75%
|
|
University of Geneva
12 publications, 0.7%
|
|
University of Copenhagen
12 publications, 0.7%
|
|
Oregon State University
12 publications, 0.7%
|
|
National Autonomous University of Mexico
12 publications, 0.7%
|
|
German Center for Infection Research
12 publications, 0.7%
|
|
Universidade Estadual Paulista
12 publications, 0.7%
|
|
University of Gothenburg
11 publications, 0.64%
|
|
University of Basel
11 publications, 0.64%
|
|
Southern Medical University
11 publications, 0.64%
|
|
Northwest University
11 publications, 0.64%
|
|
University of Eastern Piedmont Amadeo Avogadro
11 publications, 0.64%
|
|
Lanzhou University
11 publications, 0.64%
|
|
Simon Fraser University
11 publications, 0.64%
|
|
Northwest A&F University
10 publications, 0.58%
|
|
Ewha Womans University
10 publications, 0.58%
|
|
Toho University
10 publications, 0.58%
|
|
Toyama Prefectural University
10 publications, 0.58%
|
|
Fudan University
9 publications, 0.52%
|
|
Central South University
9 publications, 0.52%
|
|
Tianjin University
9 publications, 0.52%
|
|
Shanghai University of Traditional Chinese Medicine
9 publications, 0.52%
|
|
South-Central Minzu University
9 publications, 0.52%
|
|
Qingdao University
9 publications, 0.52%
|
|
Duksung Women's University
9 publications, 0.52%
|
|
Philipps University of Marburg
9 publications, 0.52%
|
|
University of Toyama
9 publications, 0.52%
|
|
University of Porto
9 publications, 0.52%
|
|
Peking University
8 publications, 0.46%
|
|
Guangzhou University of Chinese Medicine
8 publications, 0.46%
|
|
Chengdu University of Traditional Chinese Medicine
8 publications, 0.46%
|
|
Taipei Medical University
8 publications, 0.46%
|
|
University of Pisa
8 publications, 0.46%
|
|
Ningbo University
8 publications, 0.46%
|
|
University of Melbourne
8 publications, 0.46%
|
|
Chulalongkorn University
8 publications, 0.46%
|
|
Mahidol University
8 publications, 0.46%
|
|
National Center for Genetic Engineering and Biotechnology
8 publications, 0.46%
|
|
Virginia Tech
8 publications, 0.46%
|
|
Duke University Hospital
8 publications, 0.46%
|
|
Yeungnam University
8 publications, 0.46%
|
|
Nagoya University
8 publications, 0.46%
|
|
University of Szeged
8 publications, 0.46%
|
|
Federal University of São Carlos
8 publications, 0.46%
|
|
University of South Florida
8 publications, 0.46%
|
|
Guangxi Normal University
8 publications, 0.46%
|
|
Kitasato University
8 publications, 0.46%
|
|
University of the Ryukyus
8 publications, 0.46%
|
|
Shahid Beheshti University
7 publications, 0.41%
|
|
Zhejiang University
7 publications, 0.41%
|
|
Sichuan University
7 publications, 0.41%
|
|
Beijing University of Chinese Medicine
7 publications, 0.41%
|
|
Nankai University
7 publications, 0.41%
|
|
Second Military Medical University
7 publications, 0.41%
|
|
Southwest Jiaotong University
7 publications, 0.41%
|
|
Universidade Federal do Rio de Janeiro
7 publications, 0.41%
|
|
Linyi University
7 publications, 0.41%
|
|
Korea Research Institute of Bioscience and Biotechnology
7 publications, 0.41%
|
|
Gachon University
7 publications, 0.41%
|
|
Gyeongsang National University
7 publications, 0.41%
|
|
Ohio State University
7 publications, 0.41%
|
|
Korea Institute of Ocean Science & Technology
7 publications, 0.41%
|
|
Friedrich Schiller University Jena
7 publications, 0.41%
|
|
Show all (70 more) | |
10
20
30
40
50
60
70
80
|
Publishing countries
500
1000
1500
2000
2500
3000
3500
4000
|
|
USA
|
USA, 3567, 22.07%
USA
3567 publications, 22.07%
|
China
|
China, 2709, 16.76%
China
2709 publications, 16.76%
|
Japan
|
Japan, 1329, 8.22%
Japan
1329 publications, 8.22%
|
Germany
|
Germany, 666, 4.12%
Germany
666 publications, 4.12%
|
Republic of Korea
|
Republic of Korea, 582, 3.6%
Republic of Korea
582 publications, 3.6%
|
Italy
|
Italy, 490, 3.03%
Italy
490 publications, 3.03%
|
Australia
|
Australia, 453, 2.8%
Australia
453 publications, 2.8%
|
France
|
France, 373, 2.31%
France
373 publications, 2.31%
|
Spain
|
Spain, 370, 2.29%
Spain
370 publications, 2.29%
|
Brazil
|
Brazil, 344, 2.13%
Brazil
344 publications, 2.13%
|
Thailand
|
Thailand, 265, 1.64%
Thailand
265 publications, 1.64%
|
United Kingdom
|
United Kingdom, 263, 1.63%
United Kingdom
263 publications, 1.63%
|
Canada
|
Canada, 250, 1.55%
Canada
250 publications, 1.55%
|
Mexico
|
Mexico, 209, 1.29%
Mexico
209 publications, 1.29%
|
Switzerland
|
Switzerland, 177, 1.1%
Switzerland
177 publications, 1.1%
|
New Zealand
|
New Zealand, 151, 0.93%
New Zealand
151 publications, 0.93%
|
India
|
India, 147, 0.91%
India
147 publications, 0.91%
|
Netherlands
|
Netherlands, 122, 0.75%
Netherlands
122 publications, 0.75%
|
Egypt
|
Egypt, 113, 0.7%
Egypt
113 publications, 0.7%
|
Vietnam
|
Vietnam, 111, 0.69%
Vietnam
111 publications, 0.69%
|
Belgium
|
Belgium, 106, 0.66%
Belgium
106 publications, 0.66%
|
Denmark
|
Denmark, 106, 0.66%
Denmark
106 publications, 0.66%
|
Austria
|
Austria, 94, 0.58%
Austria
94 publications, 0.58%
|
Hungary
|
Hungary, 90, 0.56%
Hungary
90 publications, 0.56%
|
Malaysia
|
Malaysia, 90, 0.56%
Malaysia
90 publications, 0.56%
|
Sweden
|
Sweden, 90, 0.56%
Sweden
90 publications, 0.56%
|
Argentina
|
Argentina, 89, 0.55%
Argentina
89 publications, 0.55%
|
Russia
|
Russia, 85, 0.53%
Russia
85 publications, 0.53%
|
Indonesia
|
Indonesia, 81, 0.5%
Indonesia
81 publications, 0.5%
|
South Africa
|
South Africa, 81, 0.5%
South Africa
81 publications, 0.5%
|
Pakistan
|
Pakistan, 74, 0.46%
Pakistan
74 publications, 0.46%
|
Portugal
|
Portugal, 57, 0.35%
Portugal
57 publications, 0.35%
|
Israel
|
Israel, 57, 0.35%
Israel
57 publications, 0.35%
|
Poland
|
Poland, 55, 0.34%
Poland
55 publications, 0.34%
|
Czech Republic
|
Czech Republic, 55, 0.34%
Czech Republic
55 publications, 0.34%
|
Chile
|
Chile, 52, 0.32%
Chile
52 publications, 0.32%
|
Turkey
|
Turkey, 50, 0.31%
Turkey
50 publications, 0.31%
|
Puerto Rico
|
Puerto Rico, 42, 0.26%
Puerto Rico
42 publications, 0.26%
|
Cameroon
|
Cameroon, 40, 0.25%
Cameroon
40 publications, 0.25%
|
Saudi Arabia
|
Saudi Arabia, 39, 0.24%
Saudi Arabia
39 publications, 0.24%
|
Panama
|
Panama, 38, 0.24%
Panama
38 publications, 0.24%
|
Iran
|
Iran, 37, 0.23%
Iran
37 publications, 0.23%
|
Singapore
|
Singapore, 37, 0.23%
Singapore
37 publications, 0.23%
|
Greece
|
Greece, 36, 0.22%
Greece
36 publications, 0.22%
|
Madagascar
|
Madagascar, 36, 0.22%
Madagascar
36 publications, 0.22%
|
Finland
|
Finland, 36, 0.22%
Finland
36 publications, 0.22%
|
Kenya
|
Kenya, 32, 0.2%
Kenya
32 publications, 0.2%
|
Norway
|
Norway, 32, 0.2%
Norway
32 publications, 0.2%
|
Ireland
|
Ireland, 27, 0.17%
Ireland
27 publications, 0.17%
|
Guam
|
Guam, 26, 0.16%
Guam
26 publications, 0.16%
|
Philippines
|
Philippines, 25, 0.15%
Philippines
25 publications, 0.15%
|
Papua New Guinea
|
Papua New Guinea, 24, 0.15%
Papua New Guinea
24 publications, 0.15%
|
Colombia
|
Colombia, 20, 0.12%
Colombia
20 publications, 0.12%
|
Peru
|
Peru, 20, 0.12%
Peru
20 publications, 0.12%
|
Nigeria
|
Nigeria, 17, 0.11%
Nigeria
17 publications, 0.11%
|
Bangladesh
|
Bangladesh, 15, 0.09%
Bangladesh
15 publications, 0.09%
|
Algeria
|
Algeria, 14, 0.09%
Algeria
14 publications, 0.09%
|
Sri Lanka
|
Sri Lanka, 14, 0.09%
Sri Lanka
14 publications, 0.09%
|
Jordan
|
Jordan, 13, 0.08%
Jordan
13 publications, 0.08%
|
Serbia
|
Serbia, 13, 0.08%
Serbia
13 publications, 0.08%
|
Tanzania
|
Tanzania, 13, 0.08%
Tanzania
13 publications, 0.08%
|
Venezuela
|
Venezuela, 12, 0.07%
Venezuela
12 publications, 0.07%
|
Bulgaria
|
Bulgaria, 11, 0.07%
Bulgaria
11 publications, 0.07%
|
Costa Rica
|
Costa Rica, 11, 0.07%
Costa Rica
11 publications, 0.07%
|
New Caledonia
|
New Caledonia, 11, 0.07%
New Caledonia
11 publications, 0.07%
|
Ecuador
|
Ecuador, 11, 0.07%
Ecuador
11 publications, 0.07%
|
Ethiopia
|
Ethiopia, 11, 0.07%
Ethiopia
11 publications, 0.07%
|
Democratic Republic of the Congo
|
Democratic Republic of the Congo, 10, 0.06%
Democratic Republic of the Congo
10 publications, 0.06%
|
Morocco
|
Morocco, 9, 0.06%
Morocco
9 publications, 0.06%
|
Mongolia
|
Mongolia, 9, 0.06%
Mongolia
9 publications, 0.06%
|
Uzbekistan
|
Uzbekistan, 9, 0.06%
Uzbekistan
9 publications, 0.06%
|
Ghana
|
Ghana, 8, 0.05%
Ghana
8 publications, 0.05%
|
Myanmar
|
Myanmar, 8, 0.05%
Myanmar
8 publications, 0.05%
|
Tunisia
|
Tunisia, 7, 0.04%
Tunisia
7 publications, 0.04%
|
Mali
|
Mali, 6, 0.04%
Mali
6 publications, 0.04%
|
Slovenia
|
Slovenia, 6, 0.04%
Slovenia
6 publications, 0.04%
|
Uruguay
|
Uruguay, 6, 0.04%
Uruguay
6 publications, 0.04%
|
Fiji
|
Fiji, 6, 0.04%
Fiji
6 publications, 0.04%
|
Iraq
|
Iraq, 5, 0.03%
Iraq
5 publications, 0.03%
|
Bolivia
|
Bolivia, 4, 0.02%
Bolivia
4 publications, 0.02%
|
Zimbabwe
|
Zimbabwe, 4, 0.02%
Zimbabwe
4 publications, 0.02%
|
Iceland
|
Iceland, 4, 0.02%
Iceland
4 publications, 0.02%
|
Cyprus
|
Cyprus, 4, 0.02%
Cyprus
4 publications, 0.02%
|
Côte d'Ivoire
|
Côte d'Ivoire, 4, 0.02%
Côte d'Ivoire
4 publications, 0.02%
|
Laos
|
Laos, 4, 0.02%
Laos
4 publications, 0.02%
|
Lebanon
|
Lebanon, 4, 0.02%
Lebanon
4 publications, 0.02%
|
Luxembourg
|
Luxembourg, 4, 0.02%
Luxembourg
4 publications, 0.02%
|
Mozambique
|
Mozambique, 4, 0.02%
Mozambique
4 publications, 0.02%
|
Nepal
|
Nepal, 4, 0.02%
Nepal
4 publications, 0.02%
|
Niger
|
Niger, 4, 0.02%
Niger
4 publications, 0.02%
|
Oman
|
Oman, 4, 0.02%
Oman
4 publications, 0.02%
|
Palau
|
Palau, 4, 0.02%
Palau
4 publications, 0.02%
|
Slovakia
|
Slovakia, 4, 0.02%
Slovakia
4 publications, 0.02%
|
Sudan
|
Sudan, 4, 0.02%
Sudan
4 publications, 0.02%
|
Estonia
|
Estonia, 3, 0.02%
Estonia
3 publications, 0.02%
|
Gabon
|
Gabon, 3, 0.02%
Gabon
3 publications, 0.02%
|
Guatemala
|
Guatemala, 3, 0.02%
Guatemala
3 publications, 0.02%
|
Guinea
|
Guinea, 3, 0.02%
Guinea
3 publications, 0.02%
|
Lithuania
|
Lithuania, 3, 0.02%
Lithuania
3 publications, 0.02%
|
Paraguay
|
Paraguay, 3, 0.02%
Paraguay
3 publications, 0.02%
|
Show all (70 more) | |
500
1000
1500
2000
2500
3000
3500
4000
|
Publishing countries in 5 years
100
200
300
400
500
600
700
|
|
China
|
China, 619, 35.9%
China
619 publications, 35.9%
|
USA
|
USA, 364, 21.11%
USA
364 publications, 21.11%
|
Japan
|
Japan, 143, 8.29%
Japan
143 publications, 8.29%
|
Germany
|
Germany, 123, 7.13%
Germany
123 publications, 7.13%
|
Republic of Korea
|
Republic of Korea, 103, 5.97%
Republic of Korea
103 publications, 5.97%
|
Australia
|
Australia, 88, 5.1%
Australia
88 publications, 5.1%
|
Brazil
|
Brazil, 68, 3.94%
Brazil
68 publications, 3.94%
|
Italy
|
Italy, 61, 3.54%
Italy
61 publications, 3.54%
|
United Kingdom
|
United Kingdom, 46, 2.67%
United Kingdom
46 publications, 2.67%
|
Canada
|
Canada, 41, 2.38%
Canada
41 publications, 2.38%
|
Spain
|
Spain, 40, 2.32%
Spain
40 publications, 2.32%
|
France
|
France, 37, 2.15%
France
37 publications, 2.15%
|
Thailand
|
Thailand, 35, 2.03%
Thailand
35 publications, 2.03%
|
Switzerland
|
Switzerland, 29, 1.68%
Switzerland
29 publications, 1.68%
|
Denmark
|
Denmark, 25, 1.45%
Denmark
25 publications, 1.45%
|
Austria
|
Austria, 20, 1.16%
Austria
20 publications, 1.16%
|
Sweden
|
Sweden, 19, 1.1%
Sweden
19 publications, 1.1%
|
Hungary
|
Hungary, 18, 1.04%
Hungary
18 publications, 1.04%
|
Egypt
|
Egypt, 18, 1.04%
Egypt
18 publications, 1.04%
|
India
|
India, 18, 1.04%
India
18 publications, 1.04%
|
Malaysia
|
Malaysia, 18, 1.04%
Malaysia
18 publications, 1.04%
|
Netherlands
|
Netherlands, 17, 0.99%
Netherlands
17 publications, 0.99%
|
Russia
|
Russia, 16, 0.93%
Russia
16 publications, 0.93%
|
Mexico
|
Mexico, 16, 0.93%
Mexico
16 publications, 0.93%
|
Vietnam
|
Vietnam, 15, 0.87%
Vietnam
15 publications, 0.87%
|
Belgium
|
Belgium, 14, 0.81%
Belgium
14 publications, 0.81%
|
Indonesia
|
Indonesia, 13, 0.75%
Indonesia
13 publications, 0.75%
|
South Africa
|
South Africa, 13, 0.75%
South Africa
13 publications, 0.75%
|
New Zealand
|
New Zealand, 12, 0.7%
New Zealand
12 publications, 0.7%
|
Poland
|
Poland, 12, 0.7%
Poland
12 publications, 0.7%
|
Kenya
|
Kenya, 11, 0.64%
Kenya
11 publications, 0.64%
|
Portugal
|
Portugal, 10, 0.58%
Portugal
10 publications, 0.58%
|
Argentina
|
Argentina, 10, 0.58%
Argentina
10 publications, 0.58%
|
Iran
|
Iran, 10, 0.58%
Iran
10 publications, 0.58%
|
Pakistan
|
Pakistan, 10, 0.58%
Pakistan
10 publications, 0.58%
|
Saudi Arabia
|
Saudi Arabia, 10, 0.58%
Saudi Arabia
10 publications, 0.58%
|
Ireland
|
Ireland, 9, 0.52%
Ireland
9 publications, 0.52%
|
Cameroon
|
Cameroon, 9, 0.52%
Cameroon
9 publications, 0.52%
|
Finland
|
Finland, 9, 0.52%
Finland
9 publications, 0.52%
|
Czech Republic
|
Czech Republic, 9, 0.52%
Czech Republic
9 publications, 0.52%
|
Norway
|
Norway, 8, 0.46%
Norway
8 publications, 0.46%
|
Philippines
|
Philippines, 7, 0.41%
Philippines
7 publications, 0.41%
|
Jordan
|
Jordan, 6, 0.35%
Jordan
6 publications, 0.35%
|
Panama
|
Panama, 6, 0.35%
Panama
6 publications, 0.35%
|
Tanzania
|
Tanzania, 6, 0.35%
Tanzania
6 publications, 0.35%
|
Algeria
|
Algeria, 4, 0.23%
Algeria
4 publications, 0.23%
|
Nigeria
|
Nigeria, 4, 0.23%
Nigeria
4 publications, 0.23%
|
Serbia
|
Serbia, 4, 0.23%
Serbia
4 publications, 0.23%
|
Chile
|
Chile, 4, 0.23%
Chile
4 publications, 0.23%
|
Sri Lanka
|
Sri Lanka, 4, 0.23%
Sri Lanka
4 publications, 0.23%
|
Ghana
|
Ghana, 3, 0.17%
Ghana
3 publications, 0.17%
|
Greece
|
Greece, 3, 0.17%
Greece
3 publications, 0.17%
|
Colombia
|
Colombia, 3, 0.17%
Colombia
3 publications, 0.17%
|
Laos
|
Laos, 3, 0.17%
Laos
3 publications, 0.17%
|
Niger
|
Niger, 3, 0.17%
Niger
3 publications, 0.17%
|
Oman
|
Oman, 3, 0.17%
Oman
3 publications, 0.17%
|
Uruguay
|
Uruguay, 3, 0.17%
Uruguay
3 publications, 0.17%
|
Fiji
|
Fiji, 3, 0.17%
Fiji
3 publications, 0.17%
|
Ethiopia
|
Ethiopia, 3, 0.17%
Ethiopia
3 publications, 0.17%
|
Estonia
|
Estonia, 2, 0.12%
Estonia
2 publications, 0.12%
|
Gabon
|
Gabon, 2, 0.12%
Gabon
2 publications, 0.12%
|
Cambodia
|
Cambodia, 2, 0.12%
Cambodia
2 publications, 0.12%
|
Côte d'Ivoire
|
Côte d'Ivoire, 2, 0.12%
Côte d'Ivoire
2 publications, 0.12%
|
Latvia
|
Latvia, 2, 0.12%
Latvia
2 publications, 0.12%
|
Papua New Guinea
|
Papua New Guinea, 2, 0.12%
Papua New Guinea
2 publications, 0.12%
|
Peru
|
Peru, 2, 0.12%
Peru
2 publications, 0.12%
|
Puerto Rico
|
Puerto Rico, 2, 0.12%
Puerto Rico
2 publications, 0.12%
|
El Salvador
|
El Salvador, 2, 0.12%
El Salvador
2 publications, 0.12%
|
Singapore
|
Singapore, 2, 0.12%
Singapore
2 publications, 0.12%
|
Turkey
|
Turkey, 2, 0.12%
Turkey
2 publications, 0.12%
|
Bangladesh
|
Bangladesh, 1, 0.06%
Bangladesh
1 publication, 0.06%
|
Bulgaria
|
Bulgaria, 1, 0.06%
Bulgaria
1 publication, 0.06%
|
Venezuela
|
Venezuela, 1, 0.06%
Venezuela
1 publication, 0.06%
|
Guinea
|
Guinea, 1, 0.06%
Guinea
1 publication, 0.06%
|
Zambia
|
Zambia, 1, 0.06%
Zambia
1 publication, 0.06%
|
Israel
|
Israel, 1, 0.06%
Israel
1 publication, 0.06%
|
Iraq
|
Iraq, 1, 0.06%
Iraq
1 publication, 0.06%
|
Iceland
|
Iceland, 1, 0.06%
Iceland
1 publication, 0.06%
|
Democratic Republic of the Congo
|
Democratic Republic of the Congo, 1, 0.06%
Democratic Republic of the Congo
1 publication, 0.06%
|
Cuba
|
Cuba, 1, 0.06%
Cuba
1 publication, 0.06%
|
Kuwait
|
Kuwait, 1, 0.06%
Kuwait
1 publication, 0.06%
|
Mongolia
|
Mongolia, 1, 0.06%
Mongolia
1 publication, 0.06%
|
Myanmar
|
Myanmar, 1, 0.06%
Myanmar
1 publication, 0.06%
|
Rwanda
|
Rwanda, 1, 0.06%
Rwanda
1 publication, 0.06%
|
Romania
|
Romania, 1, 0.06%
Romania
1 publication, 0.06%
|
Slovenia
|
Slovenia, 1, 0.06%
Slovenia
1 publication, 0.06%
|
Tunisia
|
Tunisia, 1, 0.06%
Tunisia
1 publication, 0.06%
|
Uganda
|
Uganda, 1, 0.06%
Uganda
1 publication, 0.06%
|
French Guiana
|
French Guiana, 1, 0.06%
French Guiana
1 publication, 0.06%
|
Croatia
|
Croatia, 1, 0.06%
Croatia
1 publication, 0.06%
|
Eswatini
|
Eswatini, 1, 0.06%
Eswatini
1 publication, 0.06%
|
Show all (61 more) | |
100
200
300
400
500
600
700
|
30 profile journal articles
Kaiser Marcel

University of Basel

Swiss Tropical and Public Health Institute
481 publications,
13 063 citations
h-index: 56
7 profile journal articles
Rédei Dóra
43 publications,
928 citations
h-index: 16
3 profile journal articles
Bar Fatma

Prince Sattam bin Abdulaziz University

Mansoura University
66 publications,
633 citations
h-index: 15
3 profile journal articles
Wayan I

Ganesha University of Education
34 publications,
471 citations
h-index: 12
2 profile journal articles
Nemtarev Andrey
16 publications,
162 citations
h-index: 6
2 profile journal articles
Zhuravleva Olesya
PhD in Chemistry

Far Eastern Federal University

G. B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences
41 publications,
549 citations
h-index: 14
2 profile journal articles
Belenok M
45 publications,
405 citations
h-index: 11
2 profile journal articles
Knirel Yuriy
DSc in Chemistry, Professor

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences
731 publications,
15 311 citations
h-index: 53
2 profile journal articles
Perveen Shagufta

King Saud University

University of the Punjab

Government College University, Faisalabad
160 publications,
2 034 citations
h-index: 22
2 profile journal articles
Shahat Abdelaaty
163 publications,
2 584 citations
h-index: 28