Cytotoxic and Antiplatelet Aggregation Principles ofRuta Graveolens
Tian-Shung Wu
1
,
Li-Shian Shi
2
,
Jhi-Joung Wang
3
,
Song Chou Iou
4
,
Hsien-Chang Chang
4
,
Yuh-Pan Chen
4
,
Yao-Lung Kuo
5
,
Ya-Ling Chang
6
,
Che Ming Tenge
6
1
College of Pharmacy
3
Chi Mei Foundation Hospital
4
Brion Research Institute of Taiwan
|
Publication type: Journal Article
Publication date: 2003-02-01
scimago Q3
wos Q3
SJR: 0.337
CiteScore: 3.4
Impact factor: 1.5
ISSN: 00094536, 21926549
General Chemistry
Abstract
Nineteen compounds have been isolated from the methanol extract of the root and aerial parts of Ruta graveolens. The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine (5), skimmianine (7), psoralen (8), chalepensin (12), clausindin (13), and graveolinine (16) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen. Arborinine (2), dictamine (5), isopimpinellin (11), clausindin (13), and graveoline (17) exhibited cytotoxic activity against KB, Hela, DLD, NCI and Hepa tumor cell lines.
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65
Total citations:
65
Citations from 2024:
6
(9.23%)
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GOST
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Wu T. et al. Cytotoxic and Antiplatelet Aggregation Principles ofRuta Graveolens // Journal of the Chinese Chemical Society. 2003. Vol. 50. No. 1. pp. 171-178.
GOST all authors (up to 50)
Copy
Wu T., Shi L., Wang J., Iou S. C., Chang H., Chen Y., Kuo Y., Chang Y., Tenge C. M. Cytotoxic and Antiplatelet Aggregation Principles ofRuta Graveolens // Journal of the Chinese Chemical Society. 2003. Vol. 50. No. 1. pp. 171-178.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/jccs.200300024
UR - https://doi.org/10.1002/jccs.200300024
TI - Cytotoxic and Antiplatelet Aggregation Principles ofRuta Graveolens
T2 - Journal of the Chinese Chemical Society
AU - Wu, Tian-Shung
AU - Shi, Li-Shian
AU - Wang, Jhi-Joung
AU - Iou, Song Chou
AU - Chang, Hsien-Chang
AU - Chen, Yuh-Pan
AU - Kuo, Yao-Lung
AU - Chang, Ya-Ling
AU - Tenge, Che Ming
PY - 2003
DA - 2003/02/01
PB - Wiley
SP - 171-178
IS - 1
VL - 50
SN - 0009-4536
SN - 2192-6549
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2003_Wu,
author = {Tian-Shung Wu and Li-Shian Shi and Jhi-Joung Wang and Song Chou Iou and Hsien-Chang Chang and Yuh-Pan Chen and Yao-Lung Kuo and Ya-Ling Chang and Che Ming Tenge},
title = {Cytotoxic and Antiplatelet Aggregation Principles ofRuta Graveolens},
journal = {Journal of the Chinese Chemical Society},
year = {2003},
volume = {50},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/jccs.200300024},
number = {1},
pages = {171--178},
doi = {10.1002/jccs.200300024}
}
Cite this
MLA
Copy
Wu, Tian-Shung, et al. “Cytotoxic and Antiplatelet Aggregation Principles ofRuta Graveolens.” Journal of the Chinese Chemical Society, vol. 50, no. 1, Feb. 2003, pp. 171-178. https://doi.org/10.1002/jccs.200300024.