A two-step synthesis of deuterium labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid
Publication type: Journal Article
Publication date: 2012-02-09
scimago Q3
wos Q4
SJR: 0.271
CiteScore: 2.0
Impact factor: 0.9
ISSN: 03624803, 10991344
Organic Chemistry
Drug Discovery
Biochemistry
Spectroscopy
Analytical Chemistry
Radiology, Nuclear Medicine and imaging
Abstract
Labeled compounds are essential in elucidating metabolic mechanisms and reaction pathways. A two-step synthesis of deuterium-labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid is described here. The synthesis procedures involved hydrogen–deuterium exchange of nonanoic acid with 3.00 m DCl-D2O and then Kolbe electrolysis of the deuterated nonanoic acid to achieve the desired n-alkane that was confirmed by gas chromatography-mass spectrometry and 1H nuclear magnetic resonance. This method might provide an alternative route for the preparation of specifically deuterated alkanes of different chain lengths (C > 4) in which deuterium atoms are located at two adjacent carbons of the alkane's carbon chain. Copyright © 2012 John Wiley & Sons, Ltd.
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Zhou L. et al. A two-step synthesis of deuterium labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid // Journal of Labelled Compounds and Radiopharmaceuticals. 2012. Vol. 55. No. 4. pp. 158-160.
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Zhou L., BIAN X., Yang S., Mu B. A two-step synthesis of deuterium labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid // Journal of Labelled Compounds and Radiopharmaceuticals. 2012. Vol. 55. No. 4. pp. 158-160.
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TY - JOUR
DO - 10.1002/jlcr.1962
UR - https://doi.org/10.1002/jlcr.1962
TI - A two-step synthesis of deuterium labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid
T2 - Journal of Labelled Compounds and Radiopharmaceuticals
AU - Zhou, Lei
AU - BIAN, XINYU
AU - Yang, Shizhong
AU - Mu, B.-Z.
PY - 2012
DA - 2012/02/09
PB - Wiley
SP - 158-160
IS - 4
VL - 55
SN - 0362-4803
SN - 1099-1344
ER -
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BibTex (up to 50 authors)
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@article{2012_Zhou,
author = {Lei Zhou and XINYU BIAN and Shizhong Yang and B.-Z. Mu},
title = {A two-step synthesis of deuterium labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid},
journal = {Journal of Labelled Compounds and Radiopharmaceuticals},
year = {2012},
volume = {55},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/jlcr.1962},
number = {4},
pages = {158--160},
doi = {10.1002/jlcr.1962}
}
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MLA
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Zhou, Lei, et al. “A two-step synthesis of deuterium labeled 8, 8, 9, 9-d4-hexadecane from nonanoic acid.” Journal of Labelled Compounds and Radiopharmaceuticals, vol. 55, no. 4, Feb. 2012, pp. 158-160. https://doi.org/10.1002/jlcr.1962.