Journal of Neuroscience Research, volume 71, issue 1, pages 110-120
Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35)
Stepanichev Mikhail
1
,
Zdobnova Irina M.
1
,
Yakovlev A. A.
1
,
Onufriev Mikhail V.
1
,
Lazareva Natalia A.
1
,
Zarubenko Irina I.
1
,
Publication type: Journal Article
Publication date: 2002-12-11
Journal:
Journal of Neuroscience Research
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.2
ISSN: 03604012, 10974547
Cellular and Molecular Neuroscience
Abstract
Male Wistar rats received unilateral intrahippocampal injections of 3 nmol (3.18 microg) aggregated Abeta(25-35), intracerebroventricular bilateral injections of 0.5 microg human recombinant TNFalpha or both (Abeta(25-35) + TNFalpha-treated animals). Seven days after the surgery brain sections were stained with cresyl violet (Nissl), for fragmented DNA (TUNEL), glial fibrillar acidic protein (GFAP) and isolectin B4-reactive microglia. In addition, caspase-3 activity in brain regions was measured fluorometrically. The morphology of the hippocampus after the injection of Abeta(25-35) or both Abeta(25-35) and TNFalpha (but not TNFalpha alone) showed cell loss in the CA1 pyramidal cell layer. The extension of neuronal degeneration measured in the CA1 field was significantly larger in Abeta(25-35)-treated groups compared to the contralateral hemisphere of both vehicle-treated controls and animals injected with TNFalpha alone. TNFalpha augmented the Abeta(25-35)-induced damage, significantly increasing the extension of degenerating area. Administration of Abeta(25-35) caused reactive gliosis in the ipsilateral hemisphere as demonstrated by upregulation of GFAP expression and the presence of hypertrophic astrocytes in the hippocampus. This effect was much more prominent in the hippocampi of rats treated with Abeta(25-35) + TNFalpha but absent after administration of TNFalpha alone. In both Abeta(25-35)-treated groups, the damaged area of the hippocampal CA1 field and lateral band of dentate gyrus displayed many darkly stained round isolectin B4-positive phagocyte-like microglial cells. Sparse TUNEL-positive nuclei were found in the hippocampi of rats treated with Abeta(25-35) alone or together with TNFalpha, but not in the control brain sections or in brain sections of TNFalpha-injected animals. The activity of caspase-3 increased significantly in the ipsilateral hippocampus after the injection of Abeta(25-35). Surprisingly, administration of TNFalpha into the cerebral ventricles prevented this Abeta(25-35)-induced increase in hippocampal caspase-3 activity. The results are discussed from the perspective of dual (neuroprotective and neurodestructive) roles of TNF in the brain.
Citations by journals
Citations by publishers
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5
10
15
20
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Elsevier
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Elsevier
20 publications, 47.62%
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Springer Nature
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Springer Nature
6 publications, 14.29%
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Wiley
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Wiley
3 publications, 7.14%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 4.76%
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Taylor & Francis
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Taylor & Francis
2 publications, 4.76%
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Society for Neuroscience
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2 publications, 4.76%
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The American Association of Immunologists
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The American Association of Immunologists
1 publication, 2.38%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
1 publication, 2.38%
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American Society for Biochemistry and Molecular Biology
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American Society for Biochemistry and Molecular Biology
1 publication, 2.38%
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Wolters Kluwer Health
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Wolters Kluwer Health
1 publication, 2.38%
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Korean Society of Applied Pharmacology
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Korean Society of Applied Pharmacology, 1, 2.38%
Korean Society of Applied Pharmacology
1 publication, 2.38%
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American Society of Hematology
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American Society of Hematology
1 publication, 2.38%
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American Society for Cell Biology (ASCB)
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American Society for Cell Biology (ASCB)
1 publication, 2.38%
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5
10
15
20
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Stepanichev M. et al. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35) // Journal of Neuroscience Research. 2002. Vol. 71. No. 1. pp. 110-120.
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Stepanichev M., Zdobnova I. M., Yakovlev A. A., Onufriev M. V., Lazareva N. A., Zarubenko I. I., Gulyaeva N. V. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35) // Journal of Neuroscience Research. 2002. Vol. 71. No. 1. pp. 110-120.
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TY - JOUR
DO - 10.1002/jnr.10469
UR - https://doi.org/10.1002%2Fjnr.10469
TI - Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35)
T2 - Journal of Neuroscience Research
AU - Stepanichev, Mikhail
AU - Zdobnova, Irina M.
AU - Yakovlev, A. A.
AU - Onufriev, Mikhail V.
AU - Lazareva, Natalia A.
AU - Zarubenko, Irina I.
AU - Gulyaeva, Natalia V.
PY - 2002
DA - 2002/12/11 00:00:00
PB - Wiley
SP - 110-120
IS - 1
VL - 71
SN - 0360-4012
SN - 1097-4547
ER -
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@article{2002_Stepanichev,
author = {Mikhail Stepanichev and Irina M. Zdobnova and A. A. Yakovlev and Mikhail V. Onufriev and Natalia A. Lazareva and Irina I. Zarubenko and Natalia V. Gulyaeva},
title = {Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35)},
journal = {Journal of Neuroscience Research},
year = {2002},
volume = {71},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002%2Fjnr.10469},
number = {1},
pages = {110--120},
doi = {10.1002/jnr.10469}
}
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Stepanichev, Mikhail, et al. “Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35).” Journal of Neuroscience Research, vol. 71, no. 1, Dec. 2002, pp. 110-120. https://doi.org/10.1002%2Fjnr.10469.
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