Journal of Pharmaceutical Sciences, volume 61, issue 12, pages 1997-1998

β-(2-Methoxyphenoxy)lactic Acid, the Major Urinary Metabolite of Glyceryl Guaiacolate in Man

W. J. A. VANDENHEUVEL 1
, 
J. L. Smith 1
, 
R. H. SILBER 1
1
 
Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065 | 
Publication type: Journal Article
Publication date: 1972-01-01
scimago Q2
SJR: 0.705
CiteScore: 7.3
Impact factor: 3.7
ISSN: 00223549, 15206017
Pharmaceutical Science
Abstract
An acidic metabolite of glyceryl guaiacolate was isolated from human urine by solvent extraction and column chromatography. Combined GLC-mass spectrometry of the trimethylsilyl and trimethylsilyl-d9 derivatives of the metabolite and mass spectrometry of the underivatized metabolite have demonstrated its structure to be β-(2-methoxyphenoxy)lactic acid.
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