Binding of toxic metabolites of isoniazid by aconiazide
1
Connaught Laboratories Limited, Willowdale, Ontario, Canada
|
Publication type: Journal Article
Publication date: 1980-11-01
scimago Q1
wos Q2
SJR: 0.737
CiteScore: 7.2
Impact factor: 3.8
ISSN: 00223549, 15206017
PubMed ID:
7452457
Pharmaceutical Science
Abstract
Abstract
Isoniazid, the hydrazide of isonicotinic acid, is widely used in the treatment and prophylaxis of tuberculosis. The toxicity and carcinogenicity of isoniazid have been attributed to the action of its metabolites, hydrazine and acetylhydrazine. Aconiazide, the isonicotinylhydrazone of 2-formylphenoxyacetic acid, has been used in the treatment and prophylaxis of tuberculosis. Aconiazide is hydrolyzed in the body to isoniazid and 2-formylphenoxyacetic acid. 2-Formylphenoxyacetic acid has been shown to bind hydrazine and acetylhydrazine. This binding could explain the lower toxicity of aconiazide and also could provide a reason for postulating its lack of carcinogenicity.Found
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Total citations:
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Citations from 2024:
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GOST
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Held H. R., Landi S. Binding of toxic metabolites of isoniazid by aconiazide // Journal of Pharmaceutical Sciences. 1980. Vol. 69. No. 11. pp. 1284-1287.
GOST all authors (up to 50)
Copy
Held H. R., Landi S. Binding of toxic metabolites of isoniazid by aconiazide // Journal of Pharmaceutical Sciences. 1980. Vol. 69. No. 11. pp. 1284-1287.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/jps.2600691114
UR - https://doi.org/10.1002/jps.2600691114
TI - Binding of toxic metabolites of isoniazid by aconiazide
T2 - Journal of Pharmaceutical Sciences
AU - Held, Hans R
AU - Landi, Silvio
PY - 1980
DA - 1980/11/01
PB - Elsevier
SP - 1284-1287
IS - 11
VL - 69
PMID - 7452457
SN - 0022-3549
SN - 1520-6017
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1980_Held,
author = {Hans R Held and Silvio Landi},
title = {Binding of toxic metabolites of isoniazid by aconiazide},
journal = {Journal of Pharmaceutical Sciences},
year = {1980},
volume = {69},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1002/jps.2600691114},
number = {11},
pages = {1284--1287},
doi = {10.1002/jps.2600691114}
}
Cite this
MLA
Copy
Held, Hans R., and Silvio Landi. “Binding of toxic metabolites of isoniazid by aconiazide.” Journal of Pharmaceutical Sciences, vol. 69, no. 11, Nov. 1980, pp. 1284-1287. https://doi.org/10.1002/jps.2600691114.