Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography
1
Schering Corporation Bloomfield, NJ 07003.
|
Publication type: Journal Article
Publication date: 1982-06-01
scimago Q1
wos Q2
SJR: 0.737
CiteScore: 7.2
Impact factor: 3.8
ISSN: 00223549, 15206017
PubMed ID:
7097525
Pharmaceutical Science
Abstract
A rapid, reproducible high-performance liquid chromatographic system for the determination of ethinyl estradiol in solid dosage forms consisting of a reversed-phase column with a mobile phase of 0.05 M aqueous KH2PO4-methyl alcohol (2:3) and fluorescence detection has been developed. This stability-indicating method is applicable to tablets containing ethinyl estradiol alone or in combination with methyltestosterone and progesterones. The procedure has been used for the determination of ethinyl estradiol in single tablets, stability samples, and dissolution medium. Recovery of drug substance added to placebo was from 97.3 to 101.5% in stability and single-tablet assays, and 95.4 to 102.2% in dissolution assays. Reproducibility studies gave relative standard deviations of 0.4-2.2%.
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Total citations:
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Citations from 2024:
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(6.67%)
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GOST
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Strusiak S. H., HOOGERHEIDE J. G., Gardner M. S. Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography // Journal of Pharmaceutical Sciences. 1982. Vol. 71. No. 6. pp. 636-640.
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Strusiak S. H., HOOGERHEIDE J. G., Gardner M. S. Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography // Journal of Pharmaceutical Sciences. 1982. Vol. 71. No. 6. pp. 636-640.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/jps.2600710610
UR - https://doi.org/10.1002/jps.2600710610
TI - Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography
T2 - Journal of Pharmaceutical Sciences
AU - Strusiak, Suzanne H
AU - HOOGERHEIDE, JOHN G.
AU - Gardner, Maureen S
PY - 1982
DA - 1982/06/01
PB - Elsevier
SP - 636-640
IS - 6
VL - 71
PMID - 7097525
SN - 0022-3549
SN - 1520-6017
ER -
Cite this
BibTex (up to 50 authors)
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@article{1982_Strusiak,
author = {Suzanne H Strusiak and JOHN G. HOOGERHEIDE and Maureen S Gardner},
title = {Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography},
journal = {Journal of Pharmaceutical Sciences},
year = {1982},
volume = {71},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1002/jps.2600710610},
number = {6},
pages = {636--640},
doi = {10.1002/jps.2600710610}
}
Cite this
MLA
Copy
Strusiak, Suzanne H., et al. “Determination of Ethinyl Estradiol in Solid Dosage Forms by High-Performance Liquid Chromatography.” Journal of Pharmaceutical Sciences, vol. 71, no. 6, Jun. 1982, pp. 636-640. https://doi.org/10.1002/jps.2600710610.