Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery
Publication type: Journal Article
Publication date: 2010-11-11
scimago Q1
wos Q2
SJR: 0.760
CiteScore: 5.5
Impact factor: 3.3
ISSN: 14381656, 15272648
Condensed Matter Physics
General Materials Science
Abstract
We demonstrate a new one‐batch approach to the fabrication of a biocompatible Ca‐alginate film with embedded vitamin E‐loaded microspheres that could be used for planar dermal drug delivery. Stable vitamin E microspheres, coated with gum acacia, are produced by ultrasonic treatment of a two‐phase liquid system. The Fourier transform infrared spectroscopy indicates an interaction between biopolymer functional groups induced by ultrasonication. Confocal laser fluorescence microscopy, scanning electron microscopy (SEM) and atomic force microscopy (AFM) demonstrate a homogeneous microsphere distribution within the Ca‐alginate polymer film. The kinetics of in vitro vitamin E release found for the polymer film with entrapped microspheres was much more sustained (100% in 96 h) compared to the polymer film with vitamin E embedded in the free state (100% in 5 h). The novelty of the proposed research involves the ultrasonic fabrication of loaded microspheres and formation of biodegradable coating directly doped with microspheres.
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Total citations:
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Citations from 2024:
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(8.33%)
Cite this
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MLA
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GOST
Copy
Borodina T. et al. Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery // Advanced Engineering Materials. 2010. Vol. 13. No. 3. p. B123-B130.
GOST all authors (up to 50)
Copy
Borodina T., Grigoriev D., Markvicheva E., Möhwald H., Shchukin D. Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery // Advanced Engineering Materials. 2010. Vol. 13. No. 3. p. B123-B130.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/adem.201080047
UR - https://doi.org/10.1002/adem.201080047
TI - Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery
T2 - Advanced Engineering Materials
AU - Borodina, Tatiana
AU - Grigoriev, Dmitry
AU - Markvicheva, Elena
AU - Möhwald, Helmuth
AU - Shchukin, Dmitry
PY - 2010
DA - 2010/11/11
PB - Wiley
SP - B123-B130
IS - 3
VL - 13
SN - 1438-1656
SN - 1527-2648
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Borodina,
author = {Tatiana Borodina and Dmitry Grigoriev and Elena Markvicheva and Helmuth Möhwald and Dmitry Shchukin},
title = {Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery},
journal = {Advanced Engineering Materials},
year = {2010},
volume = {13},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002/adem.201080047},
number = {3},
pages = {B123--B130},
doi = {10.1002/adem.201080047}
}
Cite this
MLA
Copy
Borodina, Tatiana, et al. “Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery.” Advanced Engineering Materials, vol. 13, no. 3, Nov. 2010, pp. B123-B130. https://doi.org/10.1002/adem.201080047.
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