The Staudinger ligation-a gift to chemical biology.
Тип публикации: Journal Article
Дата публикации: 2004-06-14
SCImago Q1
Tоп 10% SCImago
БС1
SJR: 5.495
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
15199557
General Chemistry
Catalysis
Краткое описание
Although the reaction between an azide and a phosphane to form an aza-ylide was discovered by Hermann Staudinger more than 80 years ago and has found widespread application in organic synthesis, its potential as a highly chemoselective ligation method for the preparation of bioconjugates has been recognized only recently. As the two reaction partners are bioorthogonal to almost all functionalities that exist in biological systems and react at room temperature in an aqueous environment, the Staudinger ligation has even found application in the complex environment of living cells. Herein we describe the current state of knowledge on this reaction and its application both for the preparation of bioconjugates and as a ligation method in chemical biology.
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Köhn M., Breinbauer R. The Staudinger ligation-a gift to chemical biology. // Angewandte Chemie - International Edition. 2004. Vol. 43. No. 24. pp. 3106-3116.
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Köhn M., Breinbauer R. The Staudinger ligation-a gift to chemical biology. // Angewandte Chemie - International Edition. 2004. Vol. 43. No. 24. pp. 3106-3116.
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TY - JOUR
DO - 10.1002/anie.200401744
UR - https://doi.org/10.1002/anie.200401744
TI - The Staudinger ligation-a gift to chemical biology.
T2 - Angewandte Chemie - International Edition
AU - Köhn, Maja
AU - Breinbauer, Rolf
PY - 2004
DA - 2004/06/14
PB - Wiley
SP - 3106-3116
IS - 24
VL - 43
PMID - 15199557
SN - 1433-7851
SN - 1521-3773
ER -
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@article{2004_Köhn,
author = {Maja Köhn and Rolf Breinbauer},
title = {The Staudinger ligation-a gift to chemical biology.},
journal = {Angewandte Chemie - International Edition},
year = {2004},
volume = {43},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/anie.200401744},
number = {24},
pages = {3106--3116},
doi = {10.1002/anie.200401744}
}
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MLA
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Köhn, Maja, and Rolf Breinbauer. “The Staudinger ligation-a gift to chemical biology..” Angewandte Chemie - International Edition, vol. 43, no. 24, Jun. 2004, pp. 3106-3116. https://doi.org/10.1002/anie.200401744.
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