The Staudinger ligation-a gift to chemical biology.
Publication type: Journal Article
Publication date: 2004-06-14
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
15199557
General Chemistry
Catalysis
Abstract
Although the reaction between an azide and a phosphane to form an aza-ylide was discovered by Hermann Staudinger more than 80 years ago and has found widespread application in organic synthesis, its potential as a highly chemoselective ligation method for the preparation of bioconjugates has been recognized only recently. As the two reaction partners are bioorthogonal to almost all functionalities that exist in biological systems and react at room temperature in an aqueous environment, the Staudinger ligation has even found application in the complex environment of living cells. Herein we describe the current state of knowledge on this reaction and its application both for the preparation of bioconjugates and as a ligation method in chemical biology.
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Metrics
546
Total citations:
546
Citations from 2025:
20
(3.67%)
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GOST
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Köhn M., Breinbauer R. The Staudinger ligation-a gift to chemical biology. // Angewandte Chemie - International Edition. 2004. Vol. 43. No. 24. pp. 3106-3116.
GOST all authors (up to 50)
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Köhn M., Breinbauer R. The Staudinger ligation-a gift to chemical biology. // Angewandte Chemie - International Edition. 2004. Vol. 43. No. 24. pp. 3106-3116.
Cite this
RIS
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TY - JOUR
DO - 10.1002/anie.200401744
UR - https://doi.org/10.1002/anie.200401744
TI - The Staudinger ligation-a gift to chemical biology.
T2 - Angewandte Chemie - International Edition
AU - Köhn, Maja
AU - Breinbauer, Rolf
PY - 2004
DA - 2004/06/14
PB - Wiley
SP - 3106-3116
IS - 24
VL - 43
PMID - 15199557
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
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@article{2004_Köhn,
author = {Maja Köhn and Rolf Breinbauer},
title = {The Staudinger ligation-a gift to chemical biology.},
journal = {Angewandte Chemie - International Edition},
year = {2004},
volume = {43},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/anie.200401744},
number = {24},
pages = {3106--3116},
doi = {10.1002/anie.200401744}
}
Cite this
MLA
Copy
Köhn, Maja, and Rolf Breinbauer. “The Staudinger ligation-a gift to chemical biology..” Angewandte Chemie - International Edition, vol. 43, no. 24, Jun. 2004, pp. 3106-3116. https://doi.org/10.1002/anie.200401744.