Angewandte Chemie - International Edition

, volume 51 , issue 49 , pages 12289-12292

Copper/Titanium Catalysis Forms Fully Substituted Carbon Centers from the Direct Coupling of Acyclic Ketones, Amines, and Alkynes

Conor J Pierce ¹

Mary Nguyen ¹

Catharine H Larsen ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Chemistry, University of California, Riverside, CA 92521,USA |

Publication type: Journal Article

Publication date: 2012-10-26

Wiley

Angewandte Chemie - International Edition

scimago Q1

wos Q1

SJR: 5.550

CiteScore: 27.6

Impact factor: 16.9

ISSN: 14337851, 15213773

DOI: 10.1002/anie.201206674

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PubMed ID: 23109121

General Chemistry

Catalysis

Abstract

Three-component coupling, with a pair: The combination of Cu(II) and Ti(IV) catalyzes the first three-component coupling of unactivated ketones with a diverse range of amines and terminal alkynes. Tetrasubstituted propargylamines are formed under green, solvent-free conditions. This dual metal system overcomes the barrier to ketimine formation and subsequent attack, opening a new path to multicomponent reactions of ketone electrophiles.

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Pierce C. J., Nguyen M., Larsen C. H. Copper/Titanium Catalysis Forms Fully Substituted Carbon Centers from the Direct Coupling of Acyclic Ketones, Amines, and Alkynes // Angewandte Chemie - International Edition. 2012. Vol. 51. No. 49. pp. 12289-12292.

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RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/anie.201206674

UR - https://doi.org/10.1002/anie.201206674

TI - Copper/Titanium Catalysis Forms Fully Substituted Carbon Centers from the Direct Coupling of Acyclic Ketones, Amines, and Alkynes

T2 - Angewandte Chemie - International Edition

AU - Pierce, Conor J

AU - Nguyen, Mary

AU - Larsen, Catharine H

PY - 2012

DA - 2012/10/26

PB - Wiley

SP - 12289-12292

IS - 49

VL - 51

PMID - 23109121

SN - 1433-7851

SN - 1521-3773

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2012_Pierce,

author = {Conor J Pierce and Mary Nguyen and Catharine H Larsen},

title = {Copper/Titanium Catalysis Forms Fully Substituted Carbon Centers from the Direct Coupling of Acyclic Ketones, Amines, and Alkynes},

journal = {Angewandte Chemie - International Edition},

year = {2012},

volume = {51},

publisher = {Wiley},

month = {oct},

url = {https://doi.org/10.1002/anie.201206674},

number = {49},

pages = {12289--12292},

doi = {10.1002/anie.201206674}

}

MLA

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MLA Copy

Pierce, Conor J., et al. “Copper/Titanium Catalysis Forms Fully Substituted Carbon Centers from the Direct Coupling of Acyclic Ketones, Amines, and Alkynes.” Angewandte Chemie - International Edition, vol. 51, no. 49, Oct. 2012, pp. 12289-12292. https://doi.org/10.1002/anie.201206674.

Publisher

Wiley

Journal

Angewandte Chemie - International Edition

scimago Q1

wos Q1

SJR

5.550

CiteScore

27.6

Impact factor

16.9

ISSN

14337851 (Print)

15213773 (Electronic)