Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery.
Yincheng Chang
1
,
Kui Yang
1
,
Peng Wei
1
,
Sisi Huang
1
,
Yuxin Pei
1
,
Wei Zhao
1
,
Zhichao Pei
1
Publication type: Journal Article
Publication date: 2014-09-29
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
25267331
General Chemistry
Catalysis
Abstract
A novel ferrocenium capped amphiphilic pillar[5]arene (FCAP) was synthesized and self-assembled to cationic vesicles in aqueous solution. The cationic vesicles, displaying low cytotoxicity and significant redox-responsive behavior due to the redox equilibrium between ferrocenium cations and ferrocenyl groups, allow building an ideal glutathione (GSH)-responsive drug/siRNA co-delivery system for rapid drug release and gene transfection in cancer cells in which higher GSH concentration exists. This is the first report of redox-responsive vesicles assembled from pillararenes for drug/siRNA co-delivery; besides enhancing the bioavailability of drugs for cancer cells and reducing the adverse side effects for normal cells, these systems can also overcome the drug resistance of cancer cells. This work presents a good example of rational design for an effective stimuli-responsive drug/siRNA co-delivery system.
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340
Total citations:
340
Citations from 2024:
38
(11%)
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GOST
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Chang Y. et al. Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery. // Angewandte Chemie - International Edition. 2014. Vol. 53. No. 48. pp. 13126-13130.
GOST all authors (up to 50)
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Chang Y., Yang K., Wei P., Huang S., Pei Y., Zhao W., Pei Z. Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery. // Angewandte Chemie - International Edition. 2014. Vol. 53. No. 48. pp. 13126-13130.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/anie.201407272
UR - https://doi.org/10.1002/anie.201407272
TI - Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery.
T2 - Angewandte Chemie - International Edition
AU - Chang, Yincheng
AU - Yang, Kui
AU - Wei, Peng
AU - Huang, Sisi
AU - Pei, Yuxin
AU - Zhao, Wei
AU - Pei, Zhichao
PY - 2014
DA - 2014/09/29
PB - Wiley
SP - 13126-13130
IS - 48
VL - 53
PMID - 25267331
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
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@article{2014_Chang,
author = {Yincheng Chang and Kui Yang and Peng Wei and Sisi Huang and Yuxin Pei and Wei Zhao and Zhichao Pei},
title = {Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery.},
journal = {Angewandte Chemie - International Edition},
year = {2014},
volume = {53},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1002/anie.201407272},
number = {48},
pages = {13126--13130},
doi = {10.1002/anie.201407272}
}
Cite this
MLA
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Chang, Yincheng, et al. “Cationic vesicles based on amphiphilic pillar[5]arene capped with ferrocenium: a redox-responsive system for drug/siRNA co-delivery..” Angewandte Chemie - International Edition, vol. 53, no. 48, Sep. 2014, pp. 13126-13130. https://doi.org/10.1002/anie.201407272.