Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds
Jun Xu
1, 2
,
Ebrahim Alkhalil M A Ahmed
3
,
Bin Xiao
3
,
Qian-Qian Lu
3
,
Yun‐Long Wang
4
,
Chu Guo Yu
3
,
Yao Fu
3
Publication type: Journal Article
Publication date: 2015-06-01
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
26032302
General Chemistry
Catalysis
Abstract
An unprecedented Pd-catalyzed regioselective activation of gem-difluorinated cyclopropanes induced by C-C bond cleavage is reported. It provides a general and efficient access to a variety of 2-fluoroallylic amines, ethers, esters, and alkylation products in high Z-selectivity, which are important skeletons in many biologically active molecules. In addition, the transformation represents the first general application of gem-difluorinated cyclopropanes as reaction partners in transition-metal-catalyzed cross-coupling reaction.
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Metrics
155
Total citations:
155
Citations from 2025:
23
(14.84%)
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GOST
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Xu J. et al. Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds // Angewandte Chemie - International Edition. 2015. Vol. 54. No. 28. pp. 8231-8235.
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Xu J., Ahmed E. A. M. A., Xiao B., Lu Q., Wang Y., Yu C. G., Fu Y. Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds // Angewandte Chemie - International Edition. 2015. Vol. 54. No. 28. pp. 8231-8235.
Cite this
RIS
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TY - JOUR
DO - 10.1002/anie.201502308
UR - https://doi.org/10.1002/anie.201502308
TI - Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds
T2 - Angewandte Chemie - International Edition
AU - Xu, Jun
AU - Ahmed, Ebrahim Alkhalil M A
AU - Xiao, Bin
AU - Lu, Qian-Qian
AU - Wang, Yun‐Long
AU - Yu, Chu Guo
AU - Fu, Yao
PY - 2015
DA - 2015/06/01
PB - Wiley
SP - 8231-8235
IS - 28
VL - 54
PMID - 26032302
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Xu,
author = {Jun Xu and Ebrahim Alkhalil M A Ahmed and Bin Xiao and Qian-Qian Lu and Yun‐Long Wang and Chu Guo Yu and Yao Fu},
title = {Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds},
journal = {Angewandte Chemie - International Edition},
year = {2015},
volume = {54},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/anie.201502308},
number = {28},
pages = {8231--8235},
doi = {10.1002/anie.201502308}
}
Cite this
MLA
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Xu, Jun, et al. “Pd-Catalyzed Regioselective Activation ofgem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds.” Angewandte Chemie - International Edition, vol. 54, no. 28, Jun. 2015, pp. 8231-8235. https://doi.org/10.1002/anie.201502308.