volume 57 issue 35 pages 11413-11417

Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals

Publication typeJournal Article
Publication date2018-07-30
scimago Q1
wos Q1
SJR5.550
CiteScore27.6
Impact factor16.9
ISSN14337851, 15213773
General Chemistry
Catalysis
Abstract

An alkoxyl radical guided strategy for site‐selective functionalization of unactivated methylene and methine C−H bonds enabled by an FeII‐catalyzed redox process is described. The mild, expeditious, and modular protocol allows efficient remote aliphatic fluorination, chlorination, amination, and alkynylation of structurally and electronically varied primary, secondary, and tertiary hydroperoxides with excellent functional‐group tolerance. The application for one‐pot 1,4‐hydroxyl functionalization of non‐oxygenated alkane substrates initiated by aerobic C−H oxygenation is also demonstrated.

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GOST Copy
Guan H. et al. Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals // Angewandte Chemie - International Edition. 2018. Vol. 57. No. 35. pp. 11413-11417.
GOST all authors (up to 50) Copy
Guan H., Sun S., Mao Y., Chen L., Ran L., Huang J., Liu L. Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals // Angewandte Chemie - International Edition. 2018. Vol. 57. No. 35. pp. 11413-11417.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/anie.201806434
UR - https://onlinelibrary.wiley.com/doi/10.1002/anie.201806434
TI - Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals
T2 - Angewandte Chemie - International Edition
AU - Guan, Honghao
AU - Sun, Shutao
AU - Mao, Ying
AU - Chen, Lei
AU - Ran, Lu
AU - Huang, Jiancheng
AU - Liu, Lei
PY - 2018
DA - 2018/07/30
PB - Wiley
SP - 11413-11417
IS - 35
VL - 57
PMID - 30016576
SN - 1433-7851
SN - 1521-3773
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Guan,
author = {Honghao Guan and Shutao Sun and Ying Mao and Lei Chen and Lu Ran and Jiancheng Huang and Lei Liu},
title = {Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals},
journal = {Angewandte Chemie - International Edition},
year = {2018},
volume = {57},
publisher = {Wiley},
month = {jul},
url = {https://onlinelibrary.wiley.com/doi/10.1002/anie.201806434},
number = {35},
pages = {11413--11417},
doi = {10.1002/anie.201806434}
}
MLA
Cite this
MLA Copy
Guan, Honghao, et al. “Iron(II)‐Catalyzed Site‐Selective Functionalization of Unactivated C(sp3)−H Bonds Guided by Alkoxyl Radicals.” Angewandte Chemie - International Edition, vol. 57, no. 35, Jul. 2018, pp. 11413-11417. https://onlinelibrary.wiley.com/doi/10.1002/anie.201806434.