volume 59 issue 36 pages 15565-15569

Manganese‐Catalyzed anti ‐Selective Asymmetric Hydrogenation of α‐Substituted β‐Ketoamides

Publication typeJournal Article
Publication date2020-07-01
scimago Q1
wos Q1
SJR5.550
CiteScore27.6
Impact factor16.9
ISSN14337851, 15213773
General Chemistry
Catalysis
Abstract
A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive molecules and chiral drugs, were prepared in high yields with excellent selectivity (up to >99 % dr and >99 % ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations.
Found 
Found 

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GOST |
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GOST Copy
Zhang L. et al. Manganese‐Catalyzed anti ‐Selective Asymmetric Hydrogenation of α‐Substituted β‐Ketoamides // Angewandte Chemie - International Edition. 2020. Vol. 59. No. 36. pp. 15565-15569.
GOST all authors (up to 50) Copy
Zhang L., Wang Z., Han Z., Ding K. Manganese‐Catalyzed anti ‐Selective Asymmetric Hydrogenation of α‐Substituted β‐Ketoamides // Angewandte Chemie - International Edition. 2020. Vol. 59. No. 36. pp. 15565-15569.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/anie.202006383
UR - https://doi.org/10.1002/anie.202006383
TI - Manganese‐Catalyzed anti ‐Selective Asymmetric Hydrogenation of α‐Substituted β‐Ketoamides
T2 - Angewandte Chemie - International Edition
AU - Zhang, Linli
AU - Wang, Zheng
AU - Han, Zhaobin
AU - Ding, Kuiling
PY - 2020
DA - 2020/07/01
PB - Wiley
SP - 15565-15569
IS - 36
VL - 59
PMID - 32449804
SN - 1433-7851
SN - 1521-3773
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Zhang,
author = {Linli Zhang and Zheng Wang and Zhaobin Han and Kuiling Ding},
title = {Manganese‐Catalyzed anti ‐Selective Asymmetric Hydrogenation of α‐Substituted β‐Ketoamides},
journal = {Angewandte Chemie - International Edition},
year = {2020},
volume = {59},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1002/anie.202006383},
number = {36},
pages = {15565--15569},
doi = {10.1002/anie.202006383}
}
MLA
Cite this
MLA Copy
Zhang, Linli, et al. “Manganese‐Catalyzed anti ‐Selective Asymmetric Hydrogenation of α‐Substituted β‐Ketoamides.” Angewandte Chemie - International Edition, vol. 59, no. 36, Jul. 2020, pp. 15565-15569. https://doi.org/10.1002/anie.202006383.