A Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety
Publication type: Journal Article
Publication date: 2020-11-05
scimago Q1
wos Q1
SJR: 5.550
CiteScore: 27.6
Impact factor: 16.9
ISSN: 14337851, 15213773
PubMed ID:
32978887
General Chemistry
Catalysis
Abstract
Concerning that the residues of photosensitizers (PS) may cause serious side effects under light, it is of great significant to timely switch-off PS after photodynamic therapy (PDT). Herein, we proposed a supramolecular strategy to regulate the activity of PS, fabricating a supramolecular PS with improved reactive oxygen species (ROS) generation efficiency and accelerated self-degradation ability. During PDT treatment, the supramolecular PS exhibited good therapeutic efficiency as well as reduced dark toxicity. Moreover, the supramolecular PS could be degraded by ROS generated by itself and lose its PDT activities once PDT treatment finished. In this way, the side effects of PDT can be reduced without sacrificing the therapeutic efficiency. This work provides a novel strategy for smarter PDT beacon to further improve the safety of PDT treatment.
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157
Total citations:
157
Citations from 2024:
76
(48.41%)
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GOST
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Yuan B. et al. A Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety // Angewandte Chemie - International Edition. 2020. Vol. 60. No. 2. pp. 706-710.
GOST all authors (up to 50)
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Yuan B., Wu H., Wang H., Tang B., Xu J., Zhang X. A Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety // Angewandte Chemie - International Edition. 2020. Vol. 60. No. 2. pp. 706-710.
Cite this
RIS
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TY - JOUR
DO - 10.1002/anie.202012477
UR - https://doi.org/10.1002/anie.202012477
TI - A Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety
T2 - Angewandte Chemie - International Edition
AU - Yuan, Bin
AU - Wu, Han
AU - Wang, Hua
AU - Tang, Bohan
AU - Xu, Jiang-Fei
AU - Zhang, Xi
PY - 2020
DA - 2020/11/05
PB - Wiley
SP - 706-710
IS - 2
VL - 60
PMID - 32978887
SN - 1433-7851
SN - 1521-3773
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Yuan,
author = {Bin Yuan and Han Wu and Hua Wang and Bohan Tang and Jiang-Fei Xu and Xi Zhang},
title = {A Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety},
journal = {Angewandte Chemie - International Edition},
year = {2020},
volume = {60},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002/anie.202012477},
number = {2},
pages = {706--710},
doi = {10.1002/anie.202012477}
}
Cite this
MLA
Copy
Yuan, Bin, et al. “A Self‐Degradable Supramolecular Photosensitizer with High Photodynamic Therapeutic Efficiency and Improved Safety.” Angewandte Chemie - International Edition, vol. 60, no. 2, Nov. 2020, pp. 706-710. https://doi.org/10.1002/anie.202012477.