Archiv der Pharmazie, volume 354, issue 3, pages 2000281
Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells
Publication type: Journal Article
Publication date: 2020-11-27
Journal:
Archiv der Pharmazie
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 5.1
ISSN: 03656233, 15214184
Drug Discovery
Pharmaceutical Science
Abstract
Delocalized lipophilic cations (DLCs) are known as mitochondria‐addressed molecules. Mitochondria targeting may provide opportunities for tumor detection. DLCs may have antioxidant or anticancer properties. In this study, we focused on the toxicity and localization of 2‐[(E)‐2‐(5‐fluoro‐2‐methyl‐1H‐indol‐3‐yl)ethenyl]‐1,6‐dimethylpyridin‐1‐ium iodide (62E2), which has recently been found as a novel cytotoxic fluorescent compound. The excitation maximum of 62E2 is 452 ± 10 nm and its emission maximum is 579 ± 10 nm. It is accumulated in the cells and stains mitochondria in nanomolar concentrations. 62E2 is cytotoxic and mitotoxic in low micromolar concentrations, and it demonstrates some selectivity of cytotoxicity against A549 cancer cells. The closest analog of 62E2 is F16, which is the fluorescent mitotoxic agent that has been described earlier as a potential anticancer agent. We hope that 62E2 described here is useful in expanding the diversity of cyanine fluorescent mitochondrial dyes and the analysis of their structure–activity relationships.
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Frontiers in Pharmacology
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Frontiers in Pharmacology
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 100%
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Skvortsov D. et al. Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells // Archiv der Pharmazie. 2020. Vol. 354. No. 3. p. 2000281.
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Skvortsov D., Emashova S. K., Kalinina M. A., Dontsova O. A. Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells // Archiv der Pharmazie. 2020. Vol. 354. No. 3. p. 2000281.
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TY - JOUR
DO - 10.1002/ardp.202000281
UR - https://doi.org/10.1002%2Fardp.202000281
TI - Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells
T2 - Archiv der Pharmazie
AU - Emashova, Sophia K
AU - Dontsova, Olga A.
AU - Skvortsov, Dmitry
AU - Kalinina, Marina A
PY - 2020
DA - 2020/11/27 00:00:00
PB - Wiley
SP - 2000281
IS - 3
VL - 354
SN - 0365-6233
SN - 1521-4184
ER -
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@article{2020_Skvortsov,
author = {Sophia K Emashova and Olga A. Dontsova and Dmitry Skvortsov and Marina A Kalinina},
title = {Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells},
journal = {Archiv der Pharmazie},
year = {2020},
volume = {354},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002%2Fardp.202000281},
number = {3},
pages = {2000281},
doi = {10.1002/ardp.202000281}
}
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Skvortsov, Dmitry, et al. “Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells.” Archiv der Pharmazie, vol. 354, no. 3, Nov. 2020, p. 2000281. https://doi.org/10.1002%2Fardp.202000281.
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