Archiv der Pharmazie, том 354, издание 3, номер публикации: 2000281

Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells

Тип документаJournal Article
Дата публикации2020-11-27
Название журналаArchiv der Pharmazie
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ2
Импакт-фактор 20214.61
ISSN03656233, 15214184
Drug Discovery
Pharmaceutical Science
Краткое описание
Delocalized lipophilic cations (DLCs) are known as mitochondria‐addressed molecules. Mitochondria targeting may provide opportunities for tumor detection. DLCs may have antioxidant or anticancer properties. In this study, we focused on the toxicity and localization of 2‐[(E)‐2‐(5‐fluoro‐2‐methyl‐1H‐indol‐3‐yl)ethenyl]‐1,6‐dimethylpyridin‐1‐ium iodide (62E2), which has recently been found as a novel cytotoxic fluorescent compound. The excitation maximum of 62E2 is 452 ± 10 nm and its emission maximum is 579 ± 10 nm. It is accumulated in the cells and stains mitochondria in nanomolar concentrations. 62E2 is cytotoxic and mitotoxic in low micromolar concentrations, and it demonstrates some selectivity of cytotoxicity against A549 cancer cells. The closest analog of 62E2 is F16, which is the fluorescent mitotoxic agent that has been described earlier as a potential anticancer agent. We hope that 62E2 described here is useful in expanding the diversity of cyanine fluorescent mitochondrial dyes and the analysis of their structure–activity relationships.
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1. Skvortsov D.A. и др. Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells // Archiv der Pharmazie. 2020. Т. 354. № 3. С. 2000281.


DO - 10.1002/ardp.202000281

UR -

TI - Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells

T2 - Archiv der Pharmazie

AU - Skvortsov, Dmitry A.

AU - Emashova, Sophia K.

AU - Kalinina, Marina A.

AU - Dontsova, Olga A.

PY - 2020

DA - 2020/11/27

PB - Wiley

SP - 2000281

IS - 3

VL - 354

SN - 0365-6233

SN - 1521-4184

ER -

BibTex |


doi = {10.1002/ardp.202000281},

url = {},

year = 2020,

month = {nov},

publisher = {Wiley},

volume = {354},

number = {3},

pages = {2000281},

author = {Dmitry A. Skvortsov and Sophia K. Emashova and Marina A. Kalinina and Olga A. Dontsova},

title = {Cyanine mitochondrial dye with slightly selective cytotoxicity against A549 cancerous cells}


Skvortsov, Dmitry A. et al. “Cyanine Mitochondrial Dye with Slightly Selective Cytotoxicity Against A549 Cancerous Cells.” Archiv der Pharmazie 354.3 (2020): 2000281. Crossref. Web.