BioEssays

, volume 38 , issue 3 , pages 244-253

Establishing and maintaining cell polarity with mRNA localization in Drosophila

Konstantin V. Yakovlev ^{1, 2}

Y. V. Shidlovskii ¹

Paul D Schedl ^{1, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Laboratory of Gene Expression Regulation in Development; Institute of Gene Biology RAS; Moscow Russia |

A.V. Zhirmunsky Institute of Marine Biology; FEB RAS Laboratory of Cytotechnology; Vladivostok Russia |

Department of Molecular Biology; Princeton University; Princeton NJ USA |

Publication type: Journal Article

Publication date: 2016-01-15

Wiley

BioEssays

scimago Q1

wos Q2

SJR: 1.299

CiteScore: 6.2

Impact factor: 2.7

ISSN: 02659247, 15211878

DOI: 10.1002/bies.201500088

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PubMed ID: 26773560

General Biochemistry, Genetics and Molecular Biology

Abstract

How cell polarity is established and maintained is an important question in diverse biological contexts. Molecular mechanisms used to localize polarity proteins to distinct domains are likely context‐dependent and provide a feedback loop in order to maintain polarity. One such mechanism is the localized translation of mRNAs encoding polarity proteins, which will be the focus of this review and may play a more important role in the establishment and maintenance of polarity than is currently known. Localized translation of mRNAs encoding polarity proteins can be used to establish polarity in response to an external signal, and to maintain polarity by local production of polarity determinants. The importance of this mechanism is illustrated by recent findings, including orb2‐dependent localized translation of aPKC mRNA at the apical end of elongating spermatid tails in the Drosophila testis, and the apical localization of stardust A mRNA in Drosophila follicle and embryonic epithelia.

Found

4 citations

Shidlovskii Yulii

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DSc in Biological/biomedical sciences, professor

85 publications, 1 017 citations

h-index: 17

Institute of Gene Biology of the Russian Academy of Sciences

Sechenov First Moscow State Medical University

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Yakovlev K. V. et al. Establishing and maintaining cell polarity with mRNA localization in Drosophila // BioEssays. 2016. Vol. 38. No. 3. pp. 244-253.

GOST all authors (up to 50) Copy

Yakovlev K. V., Shidlovskii Y. V., Schedl P. D. Establishing and maintaining cell polarity with mRNA localization in Drosophila // BioEssays. 2016. Vol. 38. No. 3. pp. 244-253.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/bies.201500088

UR - https://doi.org/10.1002/bies.201500088

TI - Establishing and maintaining cell polarity with mRNA localization in Drosophila

T2 - BioEssays

AU - Yakovlev, Konstantin V.

AU - Shidlovskii, Y. V.

AU - Schedl, Paul D

PY - 2016

DA - 2016/01/15

PB - Wiley

SP - 244-253

IS - 3

VL - 38

PMID - 26773560

SN - 0265-9247

SN - 1521-1878

ER -

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@article{2016_Yakovlev,

author = {Konstantin V. Yakovlev and Y. V. Shidlovskii and Paul D Schedl},

title = {Establishing and maintaining cell polarity with mRNA localization in Drosophila},

journal = {BioEssays},

year = {2016},

volume = {38},

publisher = {Wiley},

month = {jan},

url = {https://doi.org/10.1002/bies.201500088},

number = {3},

pages = {244--253},

doi = {10.1002/bies.201500088}

}

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Yakovlev, Konstantin V., et al. “Establishing and maintaining cell polarity with mRNA localization in Drosophila.” BioEssays, vol. 38, no. 3, Jan. 2016, pp. 244-253. https://doi.org/10.1002/bies.201500088.