Laboratory for the Regulation of gene Expression in Development
Research in our laboratory is related to the elucidation of the molecular mechanisms that regulate gene expression. Gene expression is a fundamental process underlying the vital activity of an organism. It includes a number of sequential molecular stages: preparation of the chromatin matrix, DNA transcription, mRNA maturation and formation of ribonucleoprotein particles, their intracellular transport and translation on ribosomes. Each of these stages is controlled by a specific set of factors - molecular machines, which are usually represented by multisubunit protein complexes. We study the mechanisms of regulation of gene expression in the context of various processes at the body level, such as embryogenesis, gametogenesis, immune response, neurogenesis and brain function.
Research directions
Regulation of the expression of human UCP family genes
The study of protein complexes involved in the regulation of gene expression in higher eukaryotes
Functioning of CPEB family proteins in oogenesis, spermatogenesis and neurogenesis: mRNA localization, local translation and autoregulation
To study the role of the Brahma chromatin remodeler and related factors in the regulation of gene expression
Regulation of activation of drosophila immune response genes
Study of the molecular mechanisms of long-range interactions in the Drosophila genome
New approaches to the study of mental retardation associated with Coffin-Siris syndrome in the Drosophila melanogaster model system
Publications and patents
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