Laboratory for the Regulation of gene Expression in Development

Research in our laboratory is related to the elucidation of the molecular mechanisms that regulate gene expression. Gene expression is a fundamental process underlying the vital activity of an organism. It includes a number of sequential molecular stages: preparation of the chromatin matrix, DNA transcription, mRNA maturation and formation of ribonucleoprotein particles, their intracellular transport and translation on ribosomes. Each of these stages is controlled by a specific set of factors - molecular machines, which are usually represented by multisubunit protein complexes. We study the mechanisms of regulation of gene expression in the context of various processes at the body level, such as embryogenesis, gametogenesis, immune response, neurogenesis and brain function.