Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors
Тип публикации: Journal Article
Дата публикации: 2019-01-01
scimago Q3
wos Q3
БС2
SJR: 0.425
CiteScore: 3.5
Impact factor: 2.5
ISSN: 16121872, 16121880
PubMed ID:
30382617
General Chemistry
Biochemistry
Molecular Biology
General Medicine
Molecular Medicine
Bioengineering
Краткое описание
The approach to the novel 1‐[(2‐aminoethyl)sulfonyl]‐2‐arylpyrrolidines via unique intramolecular cyclization/aza‐Michael reactions of N‐(4,4‐diethoxybutyl)ethenesulfonamide have been developed, which benefits from high yields of target compounds, mild reaction conditions, usage of inexpensive and low‐toxic reagents, and allows for wide variability in both amine and aryl moieties. Biotesting with whole‐cell luminescent bacterial biosensors responding to DNA damage showed that all tested compounds are not genotoxic. Tested compounds differently affect the formation of biofilms by Vibrio aquamarinus DSM 26054. Some of the tested compounds were found to suppress the bacterial biofilms growth and thus are promising candidates for further studies.
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Smolobochkin A. V. et al. Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors // Chemistry and Biodiversity. 2019. Vol. 16. No. 1. p. e1800490.
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Smolobochkin A. V., Muravyeva E. A., Vagapova L. I., Knyazeva I. R., Voronina J. K., Burilov A. R., Pudovik M. A., Gildebrant A., Sergeevich Sazykin I., Sazykina M., Gazizov A. S. Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors // Chemistry and Biodiversity. 2019. Vol. 16. No. 1. p. e1800490.
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TY - JOUR
DO - 10.1002/cbdv.201800490
UR - https://doi.org/10.1002/cbdv.201800490
TI - Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors
T2 - Chemistry and Biodiversity
AU - Smolobochkin, Andrey V.
AU - Muravyeva, Ekaterina A
AU - Vagapova, Liliya I
AU - Knyazeva, Irina R
AU - Voronina, Julia K.
AU - Burilov, Alexander R.
AU - Pudovik, Michail A.
AU - Gildebrant, Anastasiya
AU - Sergeevich Sazykin, Ivan
AU - Sazykina, Marina
AU - Gazizov, Almir S.
PY - 2019
DA - 2019/01/01
PB - Wiley
SP - e1800490
IS - 1
VL - 16
PMID - 30382617
SN - 1612-1872
SN - 1612-1880
ER -
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@article{2019_Smolobochkin,
author = {Andrey V. Smolobochkin and Ekaterina A Muravyeva and Liliya I Vagapova and Irina R Knyazeva and Julia K. Voronina and Alexander R. Burilov and Michail A. Pudovik and Anastasiya Gildebrant and Ivan Sergeevich Sazykin and Marina Sazykina and Almir S. Gazizov},
title = {Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors},
journal = {Chemistry and Biodiversity},
year = {2019},
volume = {16},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1002/cbdv.201800490},
number = {1},
pages = {e1800490},
doi = {10.1002/cbdv.201800490}
}
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MLA
Скопировать
Smolobochkin, Andrey V., et al. “Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors.” Chemistry and Biodiversity, vol. 16, no. 1, Jan. 2019, p. e1800490. https://doi.org/10.1002/cbdv.201800490.