Fluorine in Medicinal Chemistry
Hans-Joachim Böhm
1
,
David Banner
1
,
Stefanie Bendels
1
,
Manfred Kansy
1
,
Bernd Kuhn
1
,
K. Müller
1
,
Ulrike Obst Sander
1
,
Martin Stahl
1
Publication type: Journal Article
Publication date: 2004-04-28
scimago Q1
wos Q3
SJR: 0.844
CiteScore: 5.2
Impact factor: 2.8
ISSN: 14394227, 14397633
PubMed ID:
15122635
Organic Chemistry
Biochemistry
Molecular Biology
Molecular Medicine
Abstract
Fluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicinal chemistry. Quite often, fluorine is introduced to improve the metabolic stability by blocking metabolically labile sites. However, fluorine can also be used to modulate the physicochemical properties, such as lipophilicity or basicity. It may exert a substantial effect on the conformation of a molecule. Increasingly, fluorine is used to enhance the binding affinity to the target protein. Recent 3D-structure determinations of protein complexes with bound fluorinated ligands have led to an improved understanding of the nonbonding protein-ligand interactions that involve fluorine.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
10
20
30
40
50
60
70
80
|
|
|
Journal of Medicinal Chemistry
73 publications, 4.99%
|
|
|
European Journal of Organic Chemistry
66 publications, 4.51%
|
|
|
Journal of Organic Chemistry
64 publications, 4.37%
|
|
|
Organic Letters
64 publications, 4.37%
|
|
|
Journal of Fluorine Chemistry
63 publications, 4.3%
|
|
|
Chemistry - A European Journal
54 publications, 3.69%
|
|
|
Angewandte Chemie
52 publications, 3.55%
|
|
|
Angewandte Chemie - International Edition
51 publications, 3.48%
|
|
|
Organic and Biomolecular Chemistry
40 publications, 2.73%
|
|
|
European Journal of Medicinal Chemistry
38 publications, 2.6%
|
|
|
Tetrahedron Letters
34 publications, 2.32%
|
|
|
Advanced Synthesis and Catalysis
32 publications, 2.19%
|
|
|
Tetrahedron
32 publications, 2.19%
|
|
|
Journal of the American Chemical Society
31 publications, 2.12%
|
|
|
Chemical Communications
29 publications, 1.98%
|
|
|
Bioorganic and Medicinal Chemistry
28 publications, 1.91%
|
|
|
Bioorganic and Medicinal Chemistry Letters
27 publications, 1.84%
|
|
|
Molecules
23 publications, 1.57%
|
|
|
Organic Chemistry Frontiers
21 publications, 1.43%
|
|
|
Synthesis
21 publications, 1.43%
|
|
|
ChemMedChem
16 publications, 1.09%
|
|
|
Beilstein Journal of Organic Chemistry
15 publications, 1.02%
|
|
|
Chemical Reviews
15 publications, 1.02%
|
|
|
RSC Advances
12 publications, 0.82%
|
|
|
ChemistrySelect
12 publications, 0.82%
|
|
|
ACS Catalysis
12 publications, 0.82%
|
|
|
Bioorganic Chemistry
10 publications, 0.68%
|
|
|
Chinese Journal of Chemistry
10 publications, 0.68%
|
|
|
Chemical Science
10 publications, 0.68%
|
|
|
10
20
30
40
50
60
70
80
|
Publishers
|
50
100
150
200
250
300
350
400
|
|
|
Wiley
390 publications, 26.64%
|
|
|
Elsevier
352 publications, 24.04%
|
|
|
American Chemical Society (ACS)
322 publications, 21.99%
|
|
|
Royal Society of Chemistry (RSC)
152 publications, 10.38%
|
|
|
Springer Nature
56 publications, 3.83%
|
|
|
MDPI
48 publications, 3.28%
|
|
|
Georg Thieme Verlag KG
32 publications, 2.19%
|
|
|
Taylor & Francis
25 publications, 1.71%
|
|
|
Beilstein-Institut
15 publications, 1.02%
|
|
|
Pleiades Publishing
7 publications, 0.48%
|
|
|
Bentham Science Publishers Ltd.
6 publications, 0.41%
|
|
|
Oxford University Press
5 publications, 0.34%
|
|
|
American Association for the Advancement of Science (AAAS)
4 publications, 0.27%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
3 publications, 0.2%
|
|
|
The Japan Institute of Heterocyclic Chemistry
3 publications, 0.2%
|
|
|
Walter de Gruyter
3 publications, 0.2%
|
|
|
Hindawi Limited
3 publications, 0.2%
|
|
|
International Union of Crystallography (IUCr)
2 publications, 0.14%
|
|
|
Shanghai Institute of Organic Chemistry
2 publications, 0.14%
|
|
|
The Society of Synthetic Organic Chemistry, Japan
2 publications, 0.14%
|
|
|
Public Library of Science (PLoS)
2 publications, 0.14%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
2 publications, 0.14%
|
|
|
Cold Spring Harbor Laboratory
2 publications, 0.14%
|
|
|
CSIRO Publishing
1 publication, 0.07%
|
|
|
Canadian Science Publishing
1 publication, 0.07%
|
|
|
National Library of Serbia
1 publication, 0.07%
|
|
|
Frontiers Media S.A.
1 publication, 0.07%
|
|
|
Cellule MathDoc/Centre Mersenne
1 publication, 0.07%
|
|
|
American Society for Biochemistry and Molecular Biology
1 publication, 0.07%
|
|
|
50
100
150
200
250
300
350
400
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
1.5k
Total citations:
1464
Citations from 2025:
86
(5.87%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Böhm H. et al. Fluorine in Medicinal Chemistry // ChemBioChem. 2004. Vol. 5. No. 5. pp. 637-643.
GOST all authors (up to 50)
Copy
Böhm H., Banner D., Bendels S., Kansy M., Kuhn B., Müller K., Obst Sander U., Stahl M. Fluorine in Medicinal Chemistry // ChemBioChem. 2004. Vol. 5. No. 5. pp. 637-643.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/cbic.200301023
UR - https://doi.org/10.1002/cbic.200301023
TI - Fluorine in Medicinal Chemistry
T2 - ChemBioChem
AU - Böhm, Hans-Joachim
AU - Banner, David
AU - Bendels, Stefanie
AU - Kansy, Manfred
AU - Kuhn, Bernd
AU - Müller, K.
AU - Obst Sander, Ulrike
AU - Stahl, Martin
PY - 2004
DA - 2004/04/28
PB - Wiley
SP - 637-643
IS - 5
VL - 5
PMID - 15122635
SN - 1439-4227
SN - 1439-7633
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2004_Böhm,
author = {Hans-Joachim Böhm and David Banner and Stefanie Bendels and Manfred Kansy and Bernd Kuhn and K. Müller and Ulrike Obst Sander and Martin Stahl},
title = {Fluorine in Medicinal Chemistry},
journal = {ChemBioChem},
year = {2004},
volume = {5},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002/cbic.200301023},
number = {5},
pages = {637--643},
doi = {10.1002/cbic.200301023}
}
Cite this
MLA
Copy
Böhm, Hans-Joachim, et al. “Fluorine in Medicinal Chemistry.” ChemBioChem, vol. 5, no. 5, Apr. 2004, pp. 637-643. https://doi.org/10.1002/cbic.200301023.