ChemBioChem, volume 16, issue 18, pages 2610-2614

Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism

Melanie Gonsior ¹

Agnes Mühlenweg ¹

Marcel Tietzmann ¹

Saskia Rausch ¹

ANNETTE POCH ¹

Roderich D. Süssmuth ¹

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Institut für Chemie; Technische Universität BerlinStrasse des 17. Juni 124; 10623 Berlin Germany |

Publication type: Journal Article

Publication date: 2015-10-30

Wiley

Journal: ChemBioChem

Quartile SCImago

Quartile WOS

Impact factor: 3.2

ISSN: 14394227, 14397633

DOI: 10.1002/cbic.201500432

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Organic Chemistry

Biochemistry

Molecular Biology

Molecular Medicine

Abstract

Feglymycin, a peptide antibiotic produced by Streptomyces sp. DSM 11171, consists mostly of nonproteinogenic phenylglycine-type amino acids. It possesses antibacterial activity against methicillin-resistant Staphylococcus aureus strains and antiviral activity against HIV. Inhibition of the early steps of bacterial peptidoglycan synthesis indicated a mode of action different from those of other peptide antibiotics. Here we describe the identification and assignment of the feglymycin (feg) biosynthesis gene cluster, which codes for a 13-module nonribosomal peptide synthetase (NRPS) system. Inactivation of an NRPS gene and supplementation of a hydroxymandelate oxidase mutant with the amino acid l-Hpg proved the identity of the feg cluster. Feeding of Hpg-related unnatural amino acids was not successful. This characterization of the feg cluster is an important step to understanding the biosynthesis of this potent antibacterial peptide.

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GOST Copy

Gonsior M. et al. Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism // ChemBioChem. 2015. Vol. 16. No. 18. pp. 2610-2614.

GOST all authors (up to 50) Copy

Gonsior M., Mühlenweg A., Tietzmann M., Rausch S., POCH A., Süssmuth R. D. Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism // ChemBioChem. 2015. Vol. 16. No. 18. pp. 2610-2614.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/cbic.201500432

UR - https://doi.org/10.1002/cbic.201500432

TI - Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism

T2 - ChemBioChem

AU - Gonsior, Melanie

AU - Mühlenweg, Agnes

AU - Tietzmann, Marcel

AU - Rausch, Saskia

AU - POCH, ANNETTE

AU - Süssmuth, Roderich D.

PY - 2015

DA - 2015/10/30

PB - Wiley

SP - 2610-2614

IS - 18

VL - 16

SN - 1439-4227

SN - 1439-7633

ER -

BibTex |

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BibTex Copy

@article{2015_Gonsior,

author = {Melanie Gonsior and Agnes Mühlenweg and Marcel Tietzmann and Saskia Rausch and ANNETTE POCH and Roderich D. Süssmuth},

title = {Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism},

journal = {ChemBioChem},

year = {2015},

volume = {16},

publisher = {Wiley},

month = {oct},

url = {https://doi.org/10.1002/cbic.201500432},

number = {18},

pages = {2610--2614},

doi = {10.1002/cbic.201500432}

}

MLA

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MLA Copy

Gonsior, Melanie, et al. “Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism.” ChemBioChem, vol. 16, no. 18, Oct. 2015, pp. 2610-2614. https://doi.org/10.1002/cbic.201500432.

Found error?

Publisher

Wiley

Journal

ChemBioChem

Quartile SCImago

Quartile WOS

Impact factor

3.2

ISSN

14394227 (Print)
14397633 (Electronic)