ChemBioChem, volume 16, issue 18, pages 2610-2614
Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism
Publication type: Journal Article
Publication date: 2015-10-30
Journal:
ChemBioChem
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor: 3.2
ISSN: 14394227, 14397633
Organic Chemistry
Biochemistry
Molecular Biology
Molecular Medicine
Abstract
Feglymycin, a peptide antibiotic produced by Streptomyces sp. DSM 11171, consists mostly of nonproteinogenic phenylglycine-type amino acids. It possesses antibacterial activity against methicillin-resistant Staphylococcus aureus strains and antiviral activity against HIV. Inhibition of the early steps of bacterial peptidoglycan synthesis indicated a mode of action different from those of other peptide antibiotics. Here we describe the identification and assignment of the feglymycin (feg) biosynthesis gene cluster, which codes for a 13-module nonribosomal peptide synthetase (NRPS) system. Inactivation of an NRPS gene and supplementation of a hydroxymandelate oxidase mutant with the amino acid l-Hpg proved the identity of the feg cluster. Feeding of Hpg-related unnatural amino acids was not successful. This characterization of the feg cluster is an important step to understanding the biosynthesis of this potent antibacterial peptide.
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Gonsior M. et al. Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism // ChemBioChem. 2015. Vol. 16. No. 18. pp. 2610-2614.
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Gonsior M., Mühlenweg A., Tietzmann M., Rausch S., POCH A., Süssmuth R. D. Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism // ChemBioChem. 2015. Vol. 16. No. 18. pp. 2610-2614.
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TY - JOUR
DO - 10.1002/cbic.201500432
UR - https://doi.org/10.1002/cbic.201500432
TI - Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism
T2 - ChemBioChem
AU - Gonsior, Melanie
AU - Mühlenweg, Agnes
AU - Tietzmann, Marcel
AU - Rausch, Saskia
AU - POCH, ANNETTE
AU - Süssmuth, Roderich D.
PY - 2015
DA - 2015/10/30
PB - Wiley
SP - 2610-2614
IS - 18
VL - 16
SN - 1439-4227
SN - 1439-7633
ER -
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@article{2015_Gonsior,
author = {Melanie Gonsior and Agnes Mühlenweg and Marcel Tietzmann and Saskia Rausch and ANNETTE POCH and Roderich D. Süssmuth},
title = {Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism},
journal = {ChemBioChem},
year = {2015},
volume = {16},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1002/cbic.201500432},
number = {18},
pages = {2610--2614},
doi = {10.1002/cbic.201500432}
}
Cite this
MLA
Copy
Gonsior, Melanie, et al. “Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism.” ChemBioChem, vol. 16, no. 18, Oct. 2015, pp. 2610-2614. https://doi.org/10.1002/cbic.201500432.