, volume 19 , issue 23 , pages 7605-7619

Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.

Hong-Dong Hao ¹

Sergio Wittlin ^{2, 3}

Yikang Wu ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institution of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86) 21-64166128 |

Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel (Switzerland) |

University of Basel, 4051 Basel (Switzerland) |

Publication type: Journal Article

Publication date: 2013-04-09

Wiley

Chemistry - A European Journal

scimago Q1

wos Q2

SJR: 0.981

CiteScore: 6.7

Impact factor: 3.7

ISSN: 09476539, 15213765

DOI: 10.1002/chem.201300076

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PubMed ID: 23576327

General Chemistry

Catalysis

Organic Chemistry

Abstract

Perhydrolysis of a sterically congested multifunctional epoxide was achieved in ethereal H2O2 with the aid of a recently developed Mo catalyst. The resulting hydroperoxide cyclized to give a 1,2,4-trioxane, which could be readily elaborated into qinghaosu and a range of novel analogues. Some of the compounds with two such trioxane moieties showed in vitro antimalarial activity comparable to or even better than that of artesunate or chloroquine.

Found

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Hao H. et al. Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides. // Chemistry - A European Journal. 2013. Vol. 19. No. 23. pp. 7605-7619.

GOST all authors (up to 50) Copy

Hao H., Wittlin S., Wu Y. Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides. // Chemistry - A European Journal. 2013. Vol. 19. No. 23. pp. 7605-7619.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/chem.201300076

UR - https://doi.org/10.1002/chem.201300076

TI - Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.

T2 - Chemistry - A European Journal

AU - Hao, Hong-Dong

AU - Wittlin, Sergio

AU - Wu, Yikang

PY - 2013

DA - 2013/04/09

PB - Wiley

SP - 7605-7619

IS - 23

VL - 19

PMID - 23576327

SN - 0947-6539

SN - 1521-3765

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2013_Hao,

author = {Hong-Dong Hao and Sergio Wittlin and Yikang Wu},

title = {Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.},

journal = {Chemistry - A European Journal},

year = {2013},

volume = {19},

publisher = {Wiley},

month = {apr},

url = {https://doi.org/10.1002/chem.201300076},

number = {23},

pages = {7605--7619},

doi = {10.1002/chem.201300076}

}

MLA

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MLA Copy

Hao, Hong-Dong, et al. “Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides..” Chemistry - A European Journal, vol. 19, no. 23, Apr. 2013, pp. 7605-7619. https://doi.org/10.1002/chem.201300076.

Publisher

Wiley

Journal

Chemistry - A European Journal

scimago Q1

wos Q2

SJR

0.981

CiteScore

6.7

Impact factor

3.7

ISSN

09476539 (Print)

15213765 (Electronic)