Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation
Тип публикации: Journal Article
Дата публикации: 2011-06-22
scimago Q1
wos Q2
БС2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
PubMed ID:
21698775
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание
Targeting DEAD-box helicase: We report the rational design of second-generation DDX3 inhibitors endowed with nanomolar antienzymatic activity in vitro and low-micromolar anti-HIV activity in infected cells. We also conducted a thorough analysis to confirm DDX3 as a valid anti-HIV target. The compounds described herein represent a significant advance in the quest for new drugs that target HIV-1 host cofactors.
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Метрики
97
Всего цитирований:
97
Цитирований c 2025:
7
(7.22%)
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ГОСТ |
RIS |
BibTex |
MLA
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ГОСТ
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Maga G. et al. Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation // ChemMedChem. 2011. Vol. 6. No. 8. pp. 1371-1389.
ГОСТ со всеми авторами (до 50)
Скопировать
Maga G., Falchi F., Radi M., Botta L., Casaluce G., Bernardini M., Miehle K., Manetti F., Garbelli A., Samuele A., Zanoli S., Este J. A., Gonzalez E., Zucca E., Paolucci S., Baldanti F., De Rijck J., Debyser Z., BOTTA M. Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation // ChemMedChem. 2011. Vol. 6. No. 8. pp. 1371-1389.
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RIS
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TY - JOUR
DO - 10.1002/cmdc.201100166
UR - https://doi.org/10.1002/cmdc.201100166
TI - Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation
T2 - ChemMedChem
AU - Maga, Giovanni
AU - Falchi, F.
AU - Radi, Marco
AU - Botta, Lorenzo
AU - Casaluce, Gianni
AU - Bernardini, Martina
AU - Miehle, Konstanze
AU - Manetti, Fabrizio
AU - Garbelli, Anna
AU - Samuele, Alberta
AU - Zanoli, Samantha
AU - Este, José A.
AU - Gonzalez, Emmanuel
AU - Zucca, Elisa
AU - Paolucci, Stefania
AU - Baldanti, Fausto
AU - De Rijck, Jan
AU - Debyser, Zeger
AU - BOTTA, Maurizio
PY - 2011
DA - 2011/06/22
PB - Wiley
SP - 1371-1389
IS - 8
VL - 6
PMID - 21698775
SN - 1860-7179
SN - 1860-7187
ER -
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BibTex (до 50 авторов)
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@article{2011_Maga,
author = {Giovanni Maga and F. Falchi and Marco Radi and Lorenzo Botta and Gianni Casaluce and Martina Bernardini and Konstanze Miehle and Fabrizio Manetti and Anna Garbelli and Alberta Samuele and Samantha Zanoli and José A. Este and Emmanuel Gonzalez and Elisa Zucca and Stefania Paolucci and Fausto Baldanti and Jan De Rijck and Zeger Debyser and Maurizio BOTTA},
title = {Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation},
journal = {ChemMedChem},
year = {2011},
volume = {6},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/cmdc.201100166},
number = {8},
pages = {1371--1389},
doi = {10.1002/cmdc.201100166}
}
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MLA
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Maga, Giovanni, et al. “Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation.” ChemMedChem, vol. 6, no. 8, Jun. 2011, pp. 1371-1389. https://doi.org/10.1002/cmdc.201100166.