Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study
Publication type: Journal Article
Publication date: 2018-01-18
scimago Q1
wos Q2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
PubMed ID:
29232489
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using in vitro cell assays. We conclude that the main cause of the observed toxicity is due to the SABRE catalyst. We therefore illustrate two catalyst removal methods: one involving deactivation and ion-exchange chromatography, and the second using biphasic catalysis. These routes produce a bolus suitable for future in vivo study.
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41
Total citations:
41
Citations from 2025:
3
(7.32%)
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GOST
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Manoharan A. et al. Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study // ChemMedChem. 2018. Vol. 13. No. 4. pp. 352-359.
GOST all authors (up to 50)
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Manoharan A., Rayner P. J., Iali W., Burns M. J., Perry V. H., Duckett S. G. Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study // ChemMedChem. 2018. Vol. 13. No. 4. pp. 352-359.
Cite this
RIS
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TY - JOUR
DO - 10.1002/cmdc.201700725
UR - https://doi.org/10.1002/cmdc.201700725
TI - Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study
T2 - ChemMedChem
AU - Manoharan, Anand
AU - Rayner, Peter J
AU - Iali, Wissam
AU - Burns, Michael J
AU - Perry, V. H.
AU - Duckett, Simon G.
PY - 2018
DA - 2018/01/18
PB - Wiley
SP - 352-359
IS - 4
VL - 13
PMID - 29232489
SN - 1860-7179
SN - 1860-7187
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Manoharan,
author = {Anand Manoharan and Peter J Rayner and Wissam Iali and Michael J Burns and V. H. Perry and Simon G. Duckett},
title = {Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study},
journal = {ChemMedChem},
year = {2018},
volume = {13},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1002/cmdc.201700725},
number = {4},
pages = {352--359},
doi = {10.1002/cmdc.201700725}
}
Cite this
MLA
Copy
Manoharan, Anand, et al. “Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study.” ChemMedChem, vol. 13, no. 4, Jan. 2018, pp. 352-359. https://doi.org/10.1002/cmdc.201700725.