Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies
Publication type: Journal Article
Publication date: 2020-02-12
scimago Q1
wos Q2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
PubMed ID:
32017384
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged structural component of bioactive molecules. This is mainly due to its contribution to a plethora of biological activities as well as to an improved pharmacokinetic profile of such bioactive molecules. The synthesis of morpholines is a subject of much study due to their biological and pharmacological importance, with the last such review being published in 2013. Here, an overview of the main approaches toward morpholine synthesis or functionalization is presented, emphasizing on novel work which has not been reviewed so far. This review is an update on synthetic strategies leading to easily accessible libraries of bioactives which are of interest for drug discovery projects.
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Total citations:
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Citations from 2025:
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Tzara A., Xanthopoulos D., Kourounakis A. P. Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies // ChemMedChem. 2020. Vol. 15. No. 5. pp. 392-403.
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Tzara A., Xanthopoulos D., Kourounakis A. P. Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies // ChemMedChem. 2020. Vol. 15. No. 5. pp. 392-403.
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TY - JOUR
DO - 10.1002/cmdc.201900682
UR - https://doi.org/10.1002/cmdc.201900682
TI - Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies
T2 - ChemMedChem
AU - Tzara, Ariadni
AU - Xanthopoulos, Dimitrios
AU - Kourounakis, Angeliki P
PY - 2020
DA - 2020/02/12
PB - Wiley
SP - 392-403
IS - 5
VL - 15
PMID - 32017384
SN - 1860-7179
SN - 1860-7187
ER -
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BibTex (up to 50 authors)
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@article{2020_Tzara,
author = {Ariadni Tzara and Dimitrios Xanthopoulos and Angeliki P Kourounakis},
title = {Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies},
journal = {ChemMedChem},
year = {2020},
volume = {15},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/cmdc.201900682},
number = {5},
pages = {392--403},
doi = {10.1002/cmdc.201900682}
}
Cite this
MLA
Copy
Tzara, Ariadni, et al. “Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies.” ChemMedChem, vol. 15, no. 5, Feb. 2020, pp. 392-403. https://doi.org/10.1002/cmdc.201900682.