Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes
Ivan A Yaremenko
2
,
Parichat Prommana
3
,
Jia-Ning Wu
4
,
Rui-Long Zhang
4
,
Jerome P L Ng
4
,
Yulia Yu Belyakova
2
,
Betty Yuen Kwan Law
4
,
Peter S Radulov
2
,
Chairat Uthaipibull
3, 5
,
3
5
Current address: Thailand Center of Excellence for Life Sciences (TCELS) Bangkok Thailand
|
Publication type: Journal Article
Publication date: 2022-09-21
scimago Q1
wos Q2
SJR: 0.717
CiteScore: 6.7
Impact factor: 3.4
ISSN: 18607179, 18607187
PubMed ID:
36045616
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Bridged aminoperoxides, for the first time, were investigated for the in vitro antimalarial activity against the chloroquine‐resistant Plasmodium falciparum strain K1 and for their cytotoxic activities against immortalized human normal liver (LO2) and lung (BEAS‐2B) cell lines as well as human liver (HepG2) and lung (A549) cancer cell lines. Aminoperoxides exhibit good cytotoxicity against lung A549 cancer cell line. Synthetic ozonides were shown to have high activity against the chloroquine‐resistant P. falciparum. A cyclic voltammetry study of peroxides was performed, and most of the compounds did not show a direct correlation in oxidative capacity‐activity. Peroxides were analyzed for ROS production to understand their mechanism of action. However, none of the compounds has an impact on ROS generation, suggesting that ozonides induce apoptosis in HepG2 cells through ROS‐independent dysfunction pathway.
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26
Total citations:
26
Citations from 2024:
18
(69.23%)
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BibTex
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GOST
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Wong V. K. W. et al. Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes // ChemMedChem. 2022. Vol. 17. No. 20.
GOST all authors (up to 50)
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Wong V. K. W., Yaremenko I. A., Prommana P., Wu J., Zhang R., Ng J. P. L., Belyakova Y. Yu., Law B. Y. K., Radulov P. S., Uthaipibull C., Wong V. K. W., Terent'ev A. O. Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes // ChemMedChem. 2022. Vol. 17. No. 20.
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RIS
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TY - JOUR
DO - 10.1002/cmdc.202200328
UR - https://doi.org/10.1002/cmdc.202200328
TI - Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes
T2 - ChemMedChem
AU - Wong, Vincent Kam Wai
AU - Yaremenko, Ivan A
AU - Prommana, Parichat
AU - Wu, Jia-Ning
AU - Zhang, Rui-Long
AU - Ng, Jerome P L
AU - Belyakova, Yulia Yu
AU - Law, Betty Yuen Kwan
AU - Radulov, Peter S
AU - Uthaipibull, Chairat
AU - Wong, Vincent Kam Wai
AU - Terent'ev, Alexander O.
PY - 2022
DA - 2022/09/21
PB - Wiley
IS - 20
VL - 17
PMID - 36045616
SN - 1860-7179
SN - 1860-7187
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Wong,
author = {Vincent Kam Wai Wong and Ivan A Yaremenko and Parichat Prommana and Jia-Ning Wu and Rui-Long Zhang and Jerome P L Ng and Yulia Yu Belyakova and Betty Yuen Kwan Law and Peter S Radulov and Chairat Uthaipibull and Vincent Kam Wai Wong and Alexander O. Terent'ev},
title = {Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes},
journal = {ChemMedChem},
year = {2022},
volume = {17},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1002/cmdc.202200328},
number = {20},
doi = {10.1002/cmdc.202200328}
}