European Journal of Organic Chemistry, volume 2022, issue 22

Total Synthesis of (−)‐Cannabidiol‐C 4

Paola Marzullo 1
Alice Maiocchi 1
Giuseppe Paladino 2
Umberto Ciriello 2
Leonardo Lo Presti 1
Daniele Passarella 1
Publication typeJournal Article
Publication date2022-06-08
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor2.8
ISSN1434193X, 10990690
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
The total synthesis of CBD-C4 (cannabidibutol) is reported. The enantioselective synthesis is based on a) the use 3,5-dimetoxybenzaldehyde as starting material, b) Corey-Bakshi-Shibata reduction, c) Claisen-Ireland rearrangement, d) ring-closing metathesis, and e) not-trivial demethylation induced by sodium ethanethiolate.

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Marzullo P. et al. Total Synthesis of (−)‐Cannabidiol‐C 4 // European Journal of Organic Chemistry. 2022. Vol. 2022. No. 22.
GOST all authors (up to 50) Copy
Marzullo P., Maiocchi A., Paladino G., Ciriello U., Lo Presti L., Passarella D. Total Synthesis of (−)‐Cannabidiol‐C 4 // European Journal of Organic Chemistry. 2022. Vol. 2022. No. 22.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1002/ejoc.202200392
UR - https://doi.org/10.1002/ejoc.202200392
TI - Total Synthesis of (−)‐Cannabidiol‐C 4
T2 - European Journal of Organic Chemistry
AU - Marzullo, Paola
AU - Maiocchi, Alice
AU - Paladino, Giuseppe
AU - Ciriello, Umberto
AU - Lo Presti, Leonardo
AU - Passarella, Daniele
PY - 2022
DA - 2022/06/08 00:00:00
PB - Wiley
IS - 22
VL - 2022
SN - 1434-193X
SN - 1099-0690
ER -
BibTex
Cite this
BibTex Copy
@article{2022_Marzullo,
author = {Paola Marzullo and Alice Maiocchi and Giuseppe Paladino and Umberto Ciriello and Leonardo Lo Presti and Daniele Passarella},
title = {Total Synthesis of (−)‐Cannabidiol‐C 4},
journal = {European Journal of Organic Chemistry},
year = {2022},
volume = {2022},
publisher = {Wiley},
month = {jun},
url = {https://doi.org/10.1002/ejoc.202200392},
number = {22},
doi = {10.1002/ejoc.202200392}
}
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