volume 15 issue 12 pages 1710-1723

Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers.

Arne Strassburg 1
Frauke Kracke 1
Julia Wenners 1
Anna Jemeljanova 1
Jannis Kuepper 1
Hanne Petersen 1
Joerg C Tiller 1
Publication typeJournal Article
Publication date2015-08-04
scimago Q1
wos Q2
SJR0.893
CiteScore8.3
Impact factor4.1
ISSN16165187, 16165195
Materials Chemistry
Biotechnology
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4-dibromo-2-butene and tetramethyl-1,3-propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more than 40,000 μg · mL(-1). They are quickly killing bacterial cells at their MIC (minimal inhibitory concentration). The highest found selectivity HC50 /MIC is more than 20,000 for S. epidermidis. Investigations on sequentially prepared PBIs with defined molecular weight Mn and tailored end groups revealed that there is a dependence of antimicrobial activity and selectivity on Mn and nature of the end groups.
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GOST Copy
Strassburg A. et al. Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers. // Macromolecular Bioscience. 2015. Vol. 15. No. 12. pp. 1710-1723.
GOST all authors (up to 50) Copy
Strassburg A., Kracke F., Wenners J., Jemeljanova A., Kuepper J., Petersen H., Tiller J. C. Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers. // Macromolecular Bioscience. 2015. Vol. 15. No. 12. pp. 1710-1723.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/mabi.201500207
UR - https://doi.org/10.1002/mabi.201500207
TI - Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers.
T2 - Macromolecular Bioscience
AU - Strassburg, Arne
AU - Kracke, Frauke
AU - Wenners, Julia
AU - Jemeljanova, Anna
AU - Kuepper, Jannis
AU - Petersen, Hanne
AU - Tiller, Joerg C
PY - 2015
DA - 2015/08/04
PB - Wiley
SP - 1710-1723
IS - 12
VL - 15
PMID - 26240988
SN - 1616-5187
SN - 1616-5195
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2015_Strassburg,
author = {Arne Strassburg and Frauke Kracke and Julia Wenners and Anna Jemeljanova and Jannis Kuepper and Hanne Petersen and Joerg C Tiller},
title = {Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers.},
journal = {Macromolecular Bioscience},
year = {2015},
volume = {15},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002/mabi.201500207},
number = {12},
pages = {1710--1723},
doi = {10.1002/mabi.201500207}
}
MLA
Cite this
MLA Copy
Strassburg, Arne, et al. “Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers..” Macromolecular Bioscience, vol. 15, no. 12, Aug. 2015, pp. 1710-1723. https://doi.org/10.1002/mabi.201500207.