Controlled Release of DNA from Self-Degrading Microcapsules
Publication type: Journal Article
Publication date: 2007-09-06
scimago Q1
wos Q2
SJR: 1.078
CiteScore: 8.4
Impact factor: 4.3
ISSN: 10221336, 15213927
Materials Chemistry
Organic Chemistry
Polymers and Plastics
Abstract
Self‐disintegrating microcapsules were prepared by encapsulating a highly active mix of proteases (Pronase®) into biodegradable polyelectrolyte shells. Pronase was captured by micron‐sized calcium carbonate particles that were subsequently embedded into onion‐like shells of poly(L‐arginine) and poly(L‐aspartic acid). EDTA treatment was used to extract the calcium carbonate constituents from the resulting core‐shell particles. As a consequence, Pronase was released into the capsule interior and started to digest the surrounding polyelectrolyte shell. Lifetimes of such self‐disintegrating capsules could be successfully adjusted to seconds, hours or days by varying the amount of encapsulated Pronase. The enzyme‐mediated, sustained release of encapsulated DNA is presented as a prospective application in drug delivery.
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Metrics
138
Total citations:
138
Citations from 2024:
4
(2.89%)
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BibTex |
MLA
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GOST
Copy
Borodina T. et al. Controlled Release of DNA from Self-Degrading Microcapsules // Macromolecular Rapid Communications. 2007. Vol. 28. No. 18–19. pp. 1894-1899.
GOST all authors (up to 50)
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Borodina T., Markvicheva E., Kunizhev S., Möhwald H., Sukhorukov G. B., Kreft O. Controlled Release of DNA from Self-Degrading Microcapsules // Macromolecular Rapid Communications. 2007. Vol. 28. No. 18–19. pp. 1894-1899.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/marc.200700409
UR - https://doi.org/10.1002/marc.200700409
TI - Controlled Release of DNA from Self-Degrading Microcapsules
T2 - Macromolecular Rapid Communications
AU - Borodina, Tatiana
AU - Markvicheva, E.
AU - Kunizhev, Stanislav
AU - Möhwald, Helmuth
AU - Sukhorukov, Gleb B.
AU - Kreft, Oliver
PY - 2007
DA - 2007/09/06
PB - Wiley
SP - 1894-1899
IS - 18–19
VL - 28
SN - 1022-1336
SN - 1521-3927
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Borodina,
author = {Tatiana Borodina and E. Markvicheva and Stanislav Kunizhev and Helmuth Möhwald and Gleb B. Sukhorukov and Oliver Kreft},
title = {Controlled Release of DNA from Self-Degrading Microcapsules},
journal = {Macromolecular Rapid Communications},
year = {2007},
volume = {28},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1002/marc.200700409},
number = {18–19},
pages = {1894--1899},
doi = {10.1002/marc.200700409}
}
Cite this
MLA
Copy
Borodina, Tatiana, et al. “Controlled Release of DNA from Self-Degrading Microcapsules.” Macromolecular Rapid Communications, vol. 28, no. 18–19, Sep. 2007, pp. 1894-1899. https://doi.org/10.1002/marc.200700409.
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