Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes
Gian Cesare Tron
1
,
Tracey Pirali
1
,
Richard A. Billington
1
,
Pier Luigi Canonico
1
,
Giovanni Sorba
1
,
Armando A. Genazzani
1
Publication type: Journal Article
Publication date: 2008-01-01
scimago Q1
wos Q1
SJR: 3.169
CiteScore: 29.5
Impact factor: 11.6
ISSN: 01986325, 10981128
PubMed ID:
17763363
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
In recent years, there has been an ever‐increasing need for rapid reactions that meet the three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions would allow medicinal chemistry to keep pace with the multitude of information derived from modern biological screening techniques. The present review describes one of these reactions, the 1,3‐dipolar cycloaddition (“click‐reaction”) between azides and alkynes catalyzed by copper (I) salts. The simplicity of this reaction and the ease of purification of the resulting products have opened new opportunities in generating vast arrays of compounds with biological potential. The present review will outline the accomplishments of this strategy achieved so far and outline some of medicinal chemistry applications in which click‐chemistry might be relevant in the future. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 278–308, 2008
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Tron G. C. et al. Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes // Medicinal Research Reviews. 2008. Vol. 28. No. 2. pp. 278-308.
GOST all authors (up to 50)
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Tron G. C., Pirali T., Billington R. A., Canonico P. L., Sorba G., Genazzani A. A. Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes // Medicinal Research Reviews. 2008. Vol. 28. No. 2. pp. 278-308.
Cite this
RIS
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TY - JOUR
DO - 10.1002/med.20107
UR - https://doi.org/10.1002/med.20107
TI - Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes
T2 - Medicinal Research Reviews
AU - Tron, Gian Cesare
AU - Pirali, Tracey
AU - Billington, Richard A.
AU - Canonico, Pier Luigi
AU - Sorba, Giovanni
AU - Genazzani, Armando A.
PY - 2008
DA - 2008/01/01
PB - Wiley
SP - 278-308
IS - 2
VL - 28
PMID - 17763363
SN - 0198-6325
SN - 1098-1128
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Tron,
author = {Gian Cesare Tron and Tracey Pirali and Richard A. Billington and Pier Luigi Canonico and Giovanni Sorba and Armando A. Genazzani},
title = {Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes},
journal = {Medicinal Research Reviews},
year = {2008},
volume = {28},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1002/med.20107},
number = {2},
pages = {278--308},
doi = {10.1002/med.20107}
}
Cite this
MLA
Copy
Tron, Gian Cesare, et al. “Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes.” Medicinal Research Reviews, vol. 28, no. 2, Jan. 2008, pp. 278-308. https://doi.org/10.1002/med.20107.