Cinnamaldehydes in Cancer Chemotherapy
Publication type: Journal Article
Publication date: 2016-02-18
scimago Q1
wos Q1
SJR: 1.477
CiteScore: 14.4
Impact factor: 6.3
ISSN: 0951418X, 10991573
DOI:
10.1002/ptr.5592
PubMed ID:
26890810
Pharmacology
Abstract
Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright © 2016 John Wiley & Sons, Ltd.
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Metrics
103
Total citations:
103
Citations from 2025:
17
(16.5%)
Cite this
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MLA
Cite this
GOST
Copy
Hong S. et al. Cinnamaldehydes in Cancer Chemotherapy // Phytotherapy Research. 2016. Vol. 30. No. 5. pp. 754-767.
GOST all authors (up to 50)
Copy
Hong S., Ismail I. A., Kang S. M., Han D. C., Kwon B. S. Cinnamaldehydes in Cancer Chemotherapy // Phytotherapy Research. 2016. Vol. 30. No. 5. pp. 754-767.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/ptr.5592
UR - https://doi.org/10.1002/ptr.5592
TI - Cinnamaldehydes in Cancer Chemotherapy
T2 - Phytotherapy Research
AU - Hong, Su-Hyung
AU - Ismail, Ismail Ahmed
AU - Kang, Sung Min
AU - Han, Dong Cho
AU - Kwon, B. S.
PY - 2016
DA - 2016/02/18
PB - Wiley
SP - 754-767
IS - 5
VL - 30
PMID - 26890810
SN - 0951-418X
SN - 1099-1573
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Hong,
author = {Su-Hyung Hong and Ismail Ahmed Ismail and Sung Min Kang and Dong Cho Han and B. S. Kwon},
title = {Cinnamaldehydes in Cancer Chemotherapy},
journal = {Phytotherapy Research},
year = {2016},
volume = {30},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002/ptr.5592},
number = {5},
pages = {754--767},
doi = {10.1002/ptr.5592}
}
Cite this
MLA
Copy
Hong, Su-Hyung, et al. “Cinnamaldehydes in Cancer Chemotherapy.” Phytotherapy Research, vol. 30, no. 5, Feb. 2016, pp. 754-767. https://doi.org/10.1002/ptr.5592.