4-Diazo and 4-(Triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as Agents Inducing Apoptosis
Alexey V Galenko
1
,
Igor Kudryavtsev
2
,
Igor V. Kudryavtsev
2
,
Maxim A Terpilowski
3
,
Maria K Serebriakova
4
,
Andrey S Trulioff
5
,
Nikolay P. Goncharov
3, 6
,
Nikolay V Goncharov
3, 6
Publication type: Journal Article
Publication date: 2017-08-31
General Chemistry
Abstract
New β-diazopyrrole and β-triazenylpyrrole derivatives were synthesized from isoxazoles and pyridinium salts in two and three steps, respectively. The apoptotic/necrotic difference for these compounds was estimated on THP-1 cell line. The most effective of the panel is methyl 3-diazo-2-(2,4-dimethylphenyl)-4-phenyl-3H-pyrrole-5-carboxylate which demonstrated cytotoxic activity from the lowest concentration of 3.3 μM with a steep rise of the apoptotic effect and the largest apoptotic/necrotic difference within the range of 3.3 to 33 μM. Moreover, this diazopyrrole showed the highest sum total of apoptotic and necrotic AUCs within the same low range of concentrations. Methyl 2-(4-bromophenyl)-3-diazo-4-(3-methoxyphenyl)-3H-pyrrole-5-carboxylate and methyl 5-(4-bromophenyl)-3-(3-methoxyphenyl)-4-(piperidin-1-yl/morpholin-4-yldiazenyl)-1H-pyrrole-2-carboxylates were found to be quite promising compounds which deserve further cytophysiological and mechanistic research using different cell lines.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Organic and Biomolecular Chemistry
2 publications, 20%
|
|
|
Journal of Organic Chemistry
2 publications, 20%
|
|
|
Synthesis
2 publications, 20%
|
|
|
Tetrahedron
1 publication, 10%
|
|
|
Molecules
1 publication, 10%
|
|
|
Synlett
1 publication, 10%
|
|
|
Russian Chemical Reviews
1 publication, 10%
|
|
|
1
2
|
Publishers
|
1
2
3
|
|
|
Georg Thieme Verlag KG
3 publications, 30%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 20%
|
|
|
American Chemical Society (ACS)
2 publications, 20%
|
|
|
Elsevier
1 publication, 10%
|
|
|
MDPI
1 publication, 10%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 10%
|
|
|
1
2
3
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
10
Total citations:
10
Citations from 2024:
2
(20%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Galenko E. E. et al. 4-Diazo and 4-(Triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as Agents Inducing Apoptosis // ChemistrySelect. 2017. Vol. 2. No. 25. pp. 7508-7513.
GOST all authors (up to 50)
Copy
Galenko E. E., Galenko A. V., Novikov M. S., Khlebnikov A. F., Kudryavtsev I., Kudryavtsev I. V., Terpilowski M. A., Serebriakova M. K., Trulioff A. S., Goncharov N. P., Goncharov N. V. 4-Diazo and 4-(Triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as Agents Inducing Apoptosis // ChemistrySelect. 2017. Vol. 2. No. 25. pp. 7508-7513.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/slct.201701538
UR - https://onlinelibrary.wiley.com/doi/10.1002/slct.201701538
TI - 4-Diazo and 4-(Triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as Agents Inducing Apoptosis
T2 - ChemistrySelect
AU - Galenko, Ekaterina E
AU - Galenko, Alexey V
AU - Novikov, Mikhail S.
AU - Khlebnikov, Alexander F
AU - Kudryavtsev, Igor
AU - Kudryavtsev, Igor V.
AU - Terpilowski, Maxim A
AU - Serebriakova, Maria K
AU - Trulioff, Andrey S
AU - Goncharov, Nikolay P.
AU - Goncharov, Nikolay V
PY - 2017
DA - 2017/08/31
PB - Wiley
SP - 7508-7513
IS - 25
VL - 2
SN - 2365-6549
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Galenko,
author = {Ekaterina E Galenko and Alexey V Galenko and Mikhail S. Novikov and Alexander F Khlebnikov and Igor Kudryavtsev and Igor V. Kudryavtsev and Maxim A Terpilowski and Maria K Serebriakova and Andrey S Trulioff and Nikolay P. Goncharov and Nikolay V Goncharov},
title = {4-Diazo and 4-(Triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as Agents Inducing Apoptosis},
journal = {ChemistrySelect},
year = {2017},
volume = {2},
publisher = {Wiley},
month = {aug},
url = {https://onlinelibrary.wiley.com/doi/10.1002/slct.201701538},
number = {25},
pages = {7508--7513},
doi = {10.1002/slct.201701538}
}
Cite this
MLA
Copy
Galenko, Ekaterina E., et al. “4-Diazo and 4-(Triaz-1-en-1-yl)-1H-pyrrole-2-carboxylates as Agents Inducing Apoptosis.” ChemistrySelect, vol. 2, no. 25, Aug. 2017, pp. 7508-7513. https://onlinelibrary.wiley.com/doi/10.1002/slct.201701538.