Small

, volume 10 , issue 6 , pages 1171-1183

Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli

Yu Hang Leung ¹

Alan M. C. Ng ^{1, 2}

Xiaoying Xu ³

ZHIYONG SHEN ³

Lee A. Gethings ⁴

Mabel Ting Wong ⁵

Charis M N Chan ⁵

Mu Yao Guo ^{1, 2}

Yip Hang Ng ¹

Wenhao Chen ¹

Patrick K. H. Lee ³

Wai Leong Mickey Chan ⁶

Li-Hong Yu ⁶

David Lee Phillips ⁶

Angel P Y Ma ⁵

Frederick C. C. Leung ⁵

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Physics; University of Hong Kong; Pokfulam Road Hong Kong |

Nanostructure Institute for Energy and Environmental Research; Division of Physical Sciences; South University of Science and Technology of China; Shenzhen China |

School of Energy and Environment; City University of Hong Kong; Kowloon Tong Hong Kong |

⁴

Pharmaceutical and Life Sciences Division; Waters Corporation; Manchester UK |

⁵

School of Biological Sciences; University of Hong Kong; Pokfulam Road Hong Kong |

⁶

Department of Chemistry; University of Hong Kong; Pokfulam Road Hong Kong |

Publication type: Journal Article

Publication date: 2013-12-17

Wiley

Small

scimago Q1

wos Q1

SJR: 3.301

CiteScore: 16.1

Impact factor: 12.1

ISSN: 16136810, 16136829

DOI: 10.1002/smll.201302434

Copy DOI

PubMed ID: 24344000

General Chemistry

Biotechnology

General Materials Science

Biomaterials

Abstract

The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally‐friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation.

Found

1 citation

Boinovich Ludmila

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A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

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Pallaeva Tatiana

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Kurchatov Complex of Crystallography and Photonics of NRC «Kurchatov Institute»

Encapsulation and release of water-insoluble components

Enzymes

Nanotechnology

Polymer micro- and nanocontainers with controlled properties

Preparation and investigation of biodegradable polyelectrolyte microcapsules for various biologically active compounds

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Targeted drug delivery

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Yushina Yulia

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V. M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences

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Emelyanenko Alexandre

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A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

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Prabhakar Pranav

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Indian Institute of Technology Madras

Lovely Professional University

Nagaland University

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Shakhov Pavel

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National Research Nuclear University MEPhI

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Panda SUJOGYA

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SAMPATH KUMAR

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Post graduate Institute of Medical Education and Research

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Cite this

GOST |

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GOST Copy

Leung Yu. H. et al. Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli // Small. 2013. Vol. 10. No. 6. pp. 1171-1183.

GOST all authors (up to 50) Copy

Leung Yu. H., Ng A. M. C., Xu X., SHEN Z., Gethings L. A., Wong M. T., Chan C. M. N., Guo M. Y., Ng Y. H., Chen W., Lee P. K. H., Chan W. L. M., Yu L., Phillips D. L., Ma A. P. Y., Leung F. C. C. Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli // Small. 2013. Vol. 10. No. 6. pp. 1171-1183.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1002/smll.201302434

UR - https://onlinelibrary.wiley.com/doi/10.1002/smll.201302434

TI - Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli

T2 - Small

AU - Leung, Yu Hang

AU - Ng, Alan M. C.

AU - Xu, Xiaoying

AU - SHEN, ZHIYONG

AU - Gethings, Lee A.

AU - Wong, Mabel Ting

AU - Chan, Charis M N

AU - Guo, Mu Yao

AU - Ng, Yip Hang

AU - Chen, Wenhao

AU - Lee, Patrick K. H.

AU - Chan, Wai Leong Mickey

AU - Yu, Li-Hong

AU - Phillips, David Lee

AU - Ma, Angel P Y

AU - Leung, Frederick C. C.

PY - 2013

DA - 2013/12/17

PB - Wiley

SP - 1171-1183

IS - 6

VL - 10

PMID - 24344000

SN - 1613-6810

SN - 1613-6829

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2013_Leung,

author = {Yu Hang Leung and Alan M. C. Ng and Xiaoying Xu and ZHIYONG SHEN and Lee A. Gethings and Mabel Ting Wong and Charis M N Chan and Mu Yao Guo and Yip Hang Ng and Wenhao Chen and Patrick K. H. Lee and Wai Leong Mickey Chan and Li-Hong Yu and David Lee Phillips and Angel P Y Ma and Frederick C. C. Leung},

title = {Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli},

journal = {Small},

year = {2013},

volume = {10},

publisher = {Wiley},

month = {dec},

url = {https://onlinelibrary.wiley.com/doi/10.1002/smll.201302434},

number = {6},

pages = {1171--1183},

doi = {10.1002/smll.201302434}

}

MLA

Cite this

MLA Copy

Leung, Yu. Hang, et al. “Mechanisms of Antibacterial Activity of MgO: Non‐ROS Mediated Toxicity of MgO Nanoparticles Towards Escherichia coli.” Small, vol. 10, no. 6, Dec. 2013, pp. 1171-1183. https://onlinelibrary.wiley.com/doi/10.1002/smll.201302434.

Publisher

Wiley

Journal

Small

scimago Q1

wos Q1

SJR

3.301

CiteScore

16.1

Impact factor

12.1

ISSN

16136810 (Print)

16136829 (Electronic)