Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation
Eisaburo Sueoka
1
,
Naoko Sueoka
2
,
Yasuko Kai
1
,
Sachiko OKABE
1
,
M SUGANUMA
1
,
Ken KANEMATSU
3
,
Tatsuo YAMAMOTO
4
,
Hirota Fujiki
1
2
Publication type: Journal Article
Publication date: 1998-11-01
scimago Q2
wos Q3
SJR: 0.748
CiteScore: 4.9
Impact factor: 2.2
ISSN: 0006291X, 10902104
PubMed ID:
9837747
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
We recently reported that morphine inhibits growth of various human cancer cell lines (IC50/2.7-8.8 mM). We then extended the study using newly synthesized morphine derivatives, such as KT-90 and KT-87, which are analgesics 5 times more potent than morphine. KT-90 was found to inhibit growth of human cancer cell lines (IC50/42-70 microM) up to 80 times more potently than morphine. As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity. This paper provides evidence that KT compounds confirmed the presence of anticancer activity of morphine in addition to its analgesic action.
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Citations from 2024:
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(2.04%)
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GOST
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Sueoka E. et al. Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation // Biochemical and Biophysical Research Communications. 1998. Vol. 252. No. 3. pp. 566-570.
GOST all authors (up to 50)
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Sueoka E., Sueoka N., Kai Y., OKABE S., SUGANUMA M., KANEMATSU K., YAMAMOTO T., Fujiki H. Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation // Biochemical and Biophysical Research Communications. 1998. Vol. 252. No. 3. pp. 566-570.
Cite this
RIS
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TY - JOUR
DO - 10.1006/bbrc.1998.9695
UR - https://doi.org/10.1006/bbrc.1998.9695
TI - Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation
T2 - Biochemical and Biophysical Research Communications
AU - Sueoka, Eisaburo
AU - Sueoka, Naoko
AU - Kai, Yasuko
AU - OKABE, Sachiko
AU - SUGANUMA, M
AU - KANEMATSU, Ken
AU - YAMAMOTO, Tatsuo
AU - Fujiki, Hirota
PY - 1998
DA - 1998/11/01
PB - Elsevier
SP - 566-570
IS - 3
VL - 252
PMID - 9837747
SN - 0006-291X
SN - 1090-2104
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1998_Sueoka,
author = {Eisaburo Sueoka and Naoko Sueoka and Yasuko Kai and Sachiko OKABE and M SUGANUMA and Ken KANEMATSU and Tatsuo YAMAMOTO and Hirota Fujiki},
title = {Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation},
journal = {Biochemical and Biophysical Research Communications},
year = {1998},
volume = {252},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1006/bbrc.1998.9695},
number = {3},
pages = {566--570},
doi = {10.1006/bbrc.1998.9695}
}
Cite this
MLA
Copy
Sueoka, Eisaburo, et al. “Anticancer Activity of Morphine and Its Synthetic Derivative, KT-90, Mediated through Apoptosis and Inhibition of NF-κB Activation.” Biochemical and Biophysical Research Communications, vol. 252, no. 3, Nov. 1998, pp. 566-570. https://doi.org/10.1006/bbrc.1998.9695.