Cellular and Molecular Life Sciences, volume 50, issue 2, pages 134-136
Aragusterol C: A novel halogenated marine steroid from an Okinawan sponge,Xestospongia sp., possessing potent antitumor activity
H. Shimura
1
,
K. Iguchi
1
,
Y. Yamada
1
,
S Nakaike
2
,
T. YAMAGISHI
2
,
K Matsumoto
2
,
C. Yokoo
2
1
Tokyo College of Pharmacy, Tokyo, Japan
|
2
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan
|
Publication type: Journal Article
Publication date: 1994-02-01
Journal:
Cellular and Molecular Life Sciences
scimago Q1
SJR: 2.274
CiteScore: 13.2
Impact factor: 6.2
ISSN: 1420682X, 14209071
PubMed ID:
8125172
Molecular Biology
Pharmacology
Cell Biology
Molecular Medicine
Cellular and Molecular Neuroscience
Abstract
A novel chlorinated steroid, aragusterol C, was isolated from an Okinawan marine sponge of the genusXestospongia. The compound strongly inhibited the proliferation of KB cells in vitro, and also showed potent in vivo antitumor activity against L1210 cells in mice. The complete structure of aragusterol C was determined by spectroscopic analysis and X-ray crystallographic analysis.
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