Naunyn-Schmiedeberg's Archives of Pharmacology, volume 396, issue 3, pages 513-524
Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells.
Nizamieva Aygul
1
,
Frolova Sheida
1, 2, 3
,
Slotvitsky Mihail
2, 3
,
Kovalenko Sandaara
2, 3
,
Tsvelaya Valeriya
2, 3
,
Nikitina Anna
1
,
Sergeevichev David
4
,
Agladze Konstantin
1, 2, 3
Publication type: Journal Article
Publication date: 2022-11-18
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.6
ISSN: 00281298, 14321912
General Medicine
Pharmacology
Abstract
Botulinum toxin A is a well-known neurotransmitter inhibitor with a wide range of applications in modern medicine. Recently, botulinum toxin A preparations have been used in clinical trials to suppress cardiac arrhythmias, especially in the postoperative period. Its antiarrhythmic action is associated with inhibition of the nervous system of the heart, but its direct effect on heart tissue remains unclear. Accordingly, we investigate the effect of botulinum toxin A on isolated cardiac cells and on layers of cardiac cells capable of conducting excitation. Cardiomyocytes of neonatal rat pups and human cardiomyocytes obtained through cell reprogramming were used. A patch-clamp study showed that botulinum toxin A inhibited fast sodium currents and L-type calcium currents in a dose-dependent manner, with no apparent effect on potassium currents. Optical mapping showed that in the presence of botulinum toxin A, the propagation of the excitation wave in the layer of cardiac cells slows down sharply, conduction at high concentrations becomes chaotic, but reentry waves do not form. The combination of botulinum toxin A with a preparation of chitosan showed a stronger inhibitory effect by an order of magnitude. Further, the inhibitory effect of botulinum toxin A is not permanent and disappears after 12 days of cell culture in a botulinum toxin A-free medium. The main conclusion of the work is that the antiarrhythmic effect of botulinum toxin A found in clinical studies is associated not only with depression of the nervous system but also with a direct effect on heart tissue. Moreover, the combination of botulinum toxin A and chitosan reduces the effective dose of botulinum toxin A.
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Naunyn-Schmiedeberg's Archives of Pharmacology
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Naunyn-Schmiedeberg's Archives of Pharmacology
1 publication, 50%
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Baylor University Medical Center Proceedings
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Baylor University Medical Center Proceedings
1 publication, 50%
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Springer Nature
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Springer Nature
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Taylor & Francis
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1
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Nizamieva A. et al. Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells. // Naunyn-Schmiedeberg's Archives of Pharmacology. 2022. Vol. 396. No. 3. pp. 513-524.
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Nizamieva A., Frolova S., Slotvitsky M., Kovalenko S., Tsvelaya V., Nikitina A., Sergeevichev D., Agladze K. Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells. // Naunyn-Schmiedeberg's Archives of Pharmacology. 2022. Vol. 396. No. 3. pp. 513-524.
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TY - JOUR
DO - 10.1007/s00210-022-02332-1
UR - https://doi.org/10.1007%2Fs00210-022-02332-1
TI - Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells.
T2 - Naunyn-Schmiedeberg's Archives of Pharmacology
AU - Nizamieva, Aygul
AU - Frolova, Sheida
AU - Slotvitsky, Mihail
AU - Kovalenko, Sandaara
AU - Tsvelaya, Valeriya
AU - Nikitina, Anna
AU - Sergeevichev, David
AU - Agladze, Konstantin
PY - 2022
DA - 2022/11/18 00:00:00
PB - Springer Nature
SP - 513-524
IS - 3
VL - 396
SN - 0028-1298
SN - 1432-1912
ER -
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@article{2022_Nizamieva,
author = {Aygul Nizamieva and Sheida Frolova and Mihail Slotvitsky and Sandaara Kovalenko and Valeriya Tsvelaya and Anna Nikitina and David Sergeevichev and Konstantin Agladze},
title = {Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells.},
journal = {Naunyn-Schmiedeberg's Archives of Pharmacology},
year = {2022},
volume = {396},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007%2Fs00210-022-02332-1},
number = {3},
pages = {513--524},
doi = {10.1007/s00210-022-02332-1}
}
Cite this
MLA
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Nizamieva, Aygul, et al. “Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells..” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 396, no. 3, Nov. 2022, pp. 513-524. https://doi.org/10.1007%2Fs00210-022-02332-1.