Bulletin of Experimental Biology and Medicine, volume 143, issue S1, pages 18-20
Effect of paclitaxel on morphology and function of rat ovaries
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Institute of Oncology, Siberian Division of Russian Academy of Medical Sciences, Russia
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Publication type: Journal Article
Publication date: 2007-01-01
scimago Q3
wos Q4
SJR: 0.245
CiteScore: 1.5
Impact factor: 0.9
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
The morphology and function of the ovaries at the early and late terms after single intravenous injection of paclitaxel in the maximum tolerated dose (MTD) were studied in female Wistar rats. Evaluation of the structural and functional elements of the female gonads showed that the targets for the drug were primordial, bi-and multilayer follicles. The number of graafian follicles and corpora lutea did not decrease. A more pronounced (copared to the control) depletion of the ovarian reserve potentialities was detected during the remote period. The drug did not decrease mating capacity and efficiency. On the other hand, high fetal mortality was observed in females treated with paclitaxel, which decreased with lengthening of the period between the cytostatic treatment and mating.
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