Bulletin of Experimental Biology and Medicine, volume 159, issue 6, pages 743-746
Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure
A M Dygai
1
,
A V Chaikovskii
1
,
V. V. Zhdanov
1
,
G N Zyuzkov
1
,
L A Stavrova
1
,
V. V. UDUT
1
,
L A Miroshnichenko
1
,
E V Simanina
1
,
T G Borovskaya
1
,
M E Poluektova
1
Publication type: Journal Article
Publication date: 2015-10-29
scimago Q3
wos Q4
SJR: 0.245
CiteScore: 1.5
Impact factor: 0.9
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
A decrease in the total number of sperm cells and reduction of spermatogonium population were observed upon cytostatic damage of spermatogenous tissue caused by single paclitaxel administration. It was established that the paclitaxel-induced damage to the testicular tissue is underlain by reduction of its regenerative potential consisting in depletion of regional precursor pool. Changes in functional activity of progenitor cells were caused not only by direct action of paclitaxel, but also by suppression of the secretory function of the tissue microenvironment.
Found
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